Protein Alignment Rh6 and TAAR1

DIOPT Version :10

• Sequence 1: NP_524368.5
• Gene: Rh6 / 41889
• FlyBaseID: FBgn0019940
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_612200.1
• Gene: TAAR1 / 134864
• HGNCID: 17734
• Length: 339
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 72/324 - (22%)
• Similarity: 133/324 - (41%)
• Gaps: 27/324 - (8%)

  Fly    53 VIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGTWIMGP 117
            |:.||.|  |.||.||:...:..|.|.||:|..:.::|..||::...:.|..::......|..|.
Human    31 VLIILTT--LVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGE 93

  Fly   118 FLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALMPL 182
            ..|:::.....:....||:.::.|:.|||..:.     .||...|.:..|::...|..:|::..:
Human    94 VFCKIHTSTDIMLSSASIFHLSFISIDRYYAVC-----DPLRYKAKMNILVICVMIFISWSVPAV 153

  Fly   183 FGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYW---HIMKAV------ 238
            |.:.....|.|.......|:..........:.:|   .::.:||.:.|::   .||..|
Human   154 FAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFS---KISGVLTFMTSFYIPGSIMLCVYYRIYL 215

  Fly   239 AAHEKA--MREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGIFES 301
            .|.|:|  :.:..:|:.:.....:...:||  |.|..|.....:.::...|.|:.|......|..
Human   216 IAKEQARLISDANQKLQIGLEMKNGISQSK--ERKAVKTLGIVMGVFLICWCPFFICTVMDPFLH 278

  Fly   302 MHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGKDDLTSDSRTQATAEIS 365
            ..:.|........|...|:..||:||...:|.:::.|:    .:..||......||.:...|:|
Human   279 YIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALK----MMLFGKIFQKDSSRCKLFLELS 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	65/295 (22%)
		TM helix 1	49..75	CDD:320207	9/21 (43%)
		TM helix 2	82..108	CDD:320207	5/25 (20%)
		TM helix 3	120..150	CDD:320207	7/29 (24%)
		TM helix 4	161..181	CDD:320207	4/19 (21%)
		TM helix 5	208..237	CDD:320207	6/31 (19%)
		TM helix 6	267..297	CDD:320207	6/29 (21%)
		TM helix 7	306..331	CDD:320207	7/24 (29%)
TAAR1	NP_612200.1	7tmA_TAAR1	26..315	CDD:320438	65/295 (22%)
		TM helix 1	26..51	CDD:320438	9/21 (43%)
		TM helix 2	58..84	CDD:320438	5/25 (20%)
		TM helix 3	96..126	CDD:320438	7/29 (24%)
		TM helix 4	138..161	CDD:320438	4/22 (18%)
		Extracellular Loop 2 (ECL2). /evidence=ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:37963465	175..186		0/10 (0%)
		TM helix 5	187..216	CDD:320438	7/31 (23%)
		TM helix 6	244..274	CDD:320438	8/31 (26%)
		TM helix 7	283..308	CDD:320438	7/24 (29%)