DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rh6 and tmtops3b

DIOPT Version :9

Sequence 1:	NP_524368.5	Gene:	Rh6 / 41889	FlyBaseID:	FBgn0019940	Length:	369	Species:	Drosophila melanogaster
Sequence 2:	NP_001269304.1	Gene:	tmtops3b / 102031126	ZFINID:	ZDB-GENE-091204-311	Length:	379	Species:	Danio rerio

Alignment Length:	330	Identity:	90/330 - (27%)
Similarity:	152/330 - (46%)	Gaps:	37/330 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YMRDGR-NLSLAESVPAEIMHMVDPYWYQWPPLEPMWFGIIGF--VIAILGTMSLAG---NFIVM 69
            ::||.. |.||.:|:               .|.:...|...|:  |..|||.:.:.|   ||:|:
Zfish     6 FLRDSSVNGSLLDSL---------------SPADQTGFSRAGYTVVAVILGIIFVFGFLCNFVVL 55

  Fly    70 YIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGTWIMGPFLCELYGMFGSLFGCVS 134
            .:|.....||||.|:.::|:..||.::.....|.......:|.|:.|...|..||...:|||.||
Zfish    56 LVFARFHVLRTPINLILLNIIVSDMLVCLFGTPLSFAASVHGRWLTGVHGCRWYGFANALFGIVS 120

  Fly   135 IWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAWALMPLFGWNRYVPEGNMTACGT 199
            :.|:.:::|:||..|:............|.|.:...|.....|.:.||.||:.|.|||..|.|..
Zfish   121 LVSLAVLSYERYSTILCSSKADASDYRKAWLFITGCWLYSLLWTVPPLLGWSSYGPEGPGTTCSV 185

  Fly   200 DYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWHIMKAVAAHEKAMREQAKKMNVASLRNSEADK 264
            .:..:....|||:|...::..|.|||.:::.|..|:  :|.|           .||.:..:.|.:
Zfish   186 QWNKRSPETRSYVICLFVFCLLLPLLLMVYCYGKIL--IAIH-----------GVAKINQTAAQR 237

  Fly   265 SKAIEIKLAKVALTTISLWFFAWTPYTIINYAGIFESMHLSPLSTICGSVFAKANAVCNPIVYGL 329
            .   |..:..:.::.:|.:...|.||.::...|.|.:...||.:::..|:.||::.|.|||:|.|
Zfish   238 R---ETHVLVMVVSMVSCYLLCWMPYGVMALLGTFSAGITSPTASVVSSLLAKSSTVLNPIIYVL 299

  Fly   330 SHPKY 334
            .:.::
Zfish   300 FNNQF 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	82/292 (28%)
		TM helix 1	50..74	CDD:320207	10/28 (36%)
		TM helix 2	83..105	CDD:320207	5/21 (24%)
		TM helix 3	121..143	CDD:320207	8/21 (38%)
		TM helix 4	165..181	CDD:320207	3/15 (20%)
		TM helix 5	209..232	CDD:320207	8/22 (36%)
		TM helix 6	273..295	CDD:320207	4/21 (19%)
		TM helix 7	306..331	CDD:320207	10/24 (42%)
tmtops3b	NP_001269304.1	7tm_1	51..297	CDD:278431	74/261 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910