Protein Alignment Rh6 and OPN1MW3

DIOPT Version :10

• Sequence 1: NP_524368.5
• Gene: Rh6 / 41889
• FlyBaseID: FBgn0019940
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_001316996.1
• Gene: OPN1MW3 / 101060233
• HGNCID: 51831
• Length: 364
• Species: Homo sapiens
• Alignment Length: 398
• Identity: 103/398 - (25%)
• Similarity: 171/398 - (42%)
• Gaps: 72/398 - (18%)

  Fly     1 MASLHPPS----------FAYMR--------DGRNLSLAESVPAEIMHMVDPYWYQWPPLEPMWF 47
            :|..||..          |.|..        :|.|..:|   |..:.|           |..:|
Human    10 LAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIA---PRWVYH-----------LTSVW- 59

  Fly    48 GIIGFVIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGT 112
             :|..|||     |:..|.:|:......|.||.|.|..:||||.:|...........|:|..||.
Human    60 -MIFVVIA-----SVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGY 118

  Fly   113 WIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMARKPLTATAAVLRLMVVWTICGAW 177
            :::|..:|.|.|...||.|...:||:.:|:::|:.|:.|........|..|::.:...|.....|
Human   119 FVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVW 183

  Fly   178 ALMPLFGWNRYVPEGNMTACGTDYFAKDWWN--RSYIIVYSLWVYLTPLLTIIFSY---WHIMKA 237
            ...|:|||:||.|.|..|:||.|.|:...:.  :||:||..:...:|||..|:..|   |..::|
Human   184 TAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRA 248

  Fly   238 VAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIIN-YAGIFES 301
            ||..:|                 |::.::..|.::.::.:..:..:.|.|.||.... :|.....
Human   249 VAKQQK-----------------ESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPG 296

  Fly   302 MHLSPLSTICGSVFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACGK--DD---LTSDSRTQAT 361
            ....||.....:.|||:..:.||::|...:.:::..:.:..     ||  ||   |:|.|:|:.:
Human   297 YPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF-----GKKVDDGSELSSASKTEVS 356

  Fly   362 AEISESQA 369
            :..|.|.|
Human   357 SVSSVSPA 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	80/295 (27%)
		TM helix 1	49..75	CDD:320207	7/25 (28%)
		TM helix 2	82..108	CDD:320207	7/25 (28%)
		TM helix 3	120..150	CDD:320207	11/29 (38%)
		TM helix 4	161..181	CDD:320207	3/19 (16%)
		TM helix 5	208..237	CDD:320207	10/33 (30%)
		TM helix 6	267..297	CDD:320207	5/30 (17%)
		TM helix 7	306..331	CDD:320207	8/24 (33%)
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		3/12 (25%)
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250|UniProtKB:P04001	17..43		2/25 (8%)
		7tm_GPCRs	42..333	CDD:475119	87/328 (27%)
		TM helix 1	56..80	CDD:410628	8/30 (27%)
		TM helix 2	89..111	CDD:410628	6/21 (29%)
		TM helix 3	127..149	CDD:410628	8/21 (38%)
		TM helix 4	171..187	CDD:410628	2/15 (13%)
		TM helix 5	217..240	CDD:410628	8/22 (36%)
		TM helix 6	267..289	CDD:410628	4/21 (19%)
		TM helix 7	301..326	CDD:410628	8/24 (33%)