Protein Alignment Rh6 and mc4r

DIOPT Version :10

• Sequence 1: NP_524368.5
• Gene: Rh6 / 41889
• FlyBaseID: FBgn0019940
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: XP_004915370.1
• Gene: mc4r / 100486677
• XenbaseID: XB-GENE-960722
• Length: 334
• Species: Xenopus tropicalis
• Alignment Length: 328
• Identity: 76/328 - (23%)
• Similarity: 126/328 - (38%)
• Gaps: 86/328 - (26%)

  Fly    53 VIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTM-FPPVVLNGFYGT---- 112
            |..|||.:||..|.:|:...:.:|.|.:|...|:.:||.:|.::..:. |..||:..|..|
 Frog    52 VFVILGIVSLMENILVIAAISRNKNLHSPMYFFICSLAVADMLVSVSNGFETVVITLFNTTDKNT 116

  Fly   113 --------WIMGPFLCELYGMFGSLFGCVSIWSMTLIAYDRYCVIVKGMA-RKPLTATAAVLRLM 168
                    .|:...:|      .||.  .||.|:..||.|||..|...:. ...:|...||:.:.
 Frog   117 QHIIVNVDNILDSVIC------SSLL--ASICSLLSIAVDRYFTIFYALQYHNIITVRRAVVIIS 173

  Fly   169 VVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWH 233
            .:||.|....::                              :||.|...|.:..|::|||:...
 Frog   174 CIWTACSISGVL------------------------------FIIYYDSAVVIICLISIIFTMLA 208

  Fly   234 IMKAVAAHEKAM-REQAKKMNVASLRNSEADKSKAIEIKLAKVALT-TISLWFF--AWTPYTIIN 294
            :|.::..|...: |...|::.|....||      ..::...|.|:| ||.|..|  .|:|:
 Frog   209 LMASLYVHMFMLARLHIKRIAVLPGTNS------VRQVTNMKGAITLTILLGVFVACWSPF---- 263

  Fly   295 YAGIFESMHL-----SPLSTICGS---------VFAKANAVCNPIVYGLSHPKYKQVLREKMPCL 345
                  .:||     .|.:..|..         :....|:|.:|::|.|...:.::..:|.|.|.
 Frog   264 ------FLHLIFYVSCPRNPYCVCFMSHFNIYLILIMCNSVIDPLIYALRSQELRKTFKEMMCCY 322

  Fly   346 ACG 348
            ..|
 Frog   323 CMG 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	72/316 (23%)
		TM helix 1	49..75	CDD:320207	8/21 (38%)
		TM helix 2	82..108	CDD:320207	7/26 (27%)
		TM helix 3	120..150	CDD:320207	11/29 (38%)
		TM helix 4	161..181	CDD:320207	5/19 (26%)
		TM helix 5	208..237	CDD:320207	9/28 (32%)
		TM helix 6	267..297	CDD:320207	9/32 (28%)
		TM helix 7	306..331	CDD:320207	7/33 (21%)
mc4r	XP_004915370.1	7tm_GPCRs	47..315	CDD:475119	72/316 (23%)
		TM helix 1	49..73	CDD:410628	8/20 (40%)
		TM helix 2	82..104	CDD:410628	5/21 (24%)
		TM helix 3	125..147	CDD:410628	8/29 (28%)
		TM helix 4	170..186	CDD:410628	3/45 (7%)
		TM helix 5	192..215	CDD:410628	6/22 (27%)
		TM helix 6	246..268	CDD:410628	9/31 (29%)
		TM helix 7	283..308	CDD:410628	5/24 (21%)