DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADAMTSL2

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_011517543.2	Gene:	ADAMTSL2 / 9719	HGNCID:	14631	Length:	1021	Species:	Homo sapiens

Alignment Length:	1007	Identity:	195/1007 - (19%)
Similarity:	291/1007 - (28%)	Gaps:	418/1007 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 ADGT------PCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQ 780
            |.||      |.|:|.     .:|.|.:...|........|.||      ||..|.:.|
Human   156 APGTGPARARPSGTSS-----AECRSVRRTGGASARSSASPSTP------TCTTGGRTS------ 203

  Fly   781 PVPENGGKYCTGSRKKYRSCNTHQC--PPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYEKD 843
                  |..||.........|...|  ||          :..:|           :.|.|
Human   204 ------GSLCTRMTMSTSPANRVTCTVPP----------WTASG-----------SSWSP----- 236

  Fly   844 ACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRN 908
                      ..|.....|:..:|.:|           :..|.|||..|.|...|||||:|:|..
Human   237 ----------PATAHPASSLTCEGFAC-----------LENPIGCDGVLFSTHTLDKCGICQGDG 280

  Fly   909 DTCHEVTGNLLVSNL-LGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNEL 972
            .:|..||||....|. ||.:          .||.||.||.:|.|.:| ....:.:.|.|:.....
Human   281 SSCTHVTGNYRKGNAHLGYS----------LVTHIPAGARDIQIVER-KKSADVLALADEAGYYF 334

  Fly   973 LNGKFLKTYPLKFVYAGVTMQY--------TGSSSVVEQVNT------------------TYSWK 1011
            .||.:....|..|..||..::|        ||...:|.|..|                  |:.:.
Human   335 FNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYT 399

  Fly  1012 L------SRDLIVQI----------------------------------------------ISLD 1024
            |      ||...:..                                              :.::
Human   400 LLQPPHESRPQPIYYGFSESAESQGLDGAGLMGFVPHNGSLYGQASSERLGLDNRLFGHPGLDME 464

  Fly  1025 VSPSKRQDT-------------------------------------------------------- 1033
            :.||:.|:|
Human   465 LGPSQGQETNEVCEQAGGGACEGPPRGKGFRDRNVTGTPLTGDKDDEEVDTHFASQEFFSANAIS 529

  Fly  1034 ------------------------------------------------VLLSYSY---TIDKPPD 1047
                                                            .||:.||   :.|:..:
Human   530 DQLLGAGSDLKDFTLNETVNSIFAQGAPRSSLAESFFVDYEENEGAGPYLLNGSYLELSSDRVAN 594

  Fly  1048 YEAE----------------------------------VEIYRWEMQAPSNCDSLC-EGRSHRLP 1077
            ..:|                                  .::|||::.:...|.:.| .|......
Human   595 SSSEAPFPNVSTSLLTSAGNRTHKARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYA 659

  Fly  1078 ACISTTQGVKVAPQFCDKSAMPK-IDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQT 1141
            .|: ...||:|...:||....|: :.:.....:|:.....:|.||||..||| |.:.:...|.:.
Human   660 MCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGE-GYQFRVVRCWKM 722

  Fly  1142 FTNMQRSNIVDMSYCKLKFDVAYHEE--CRE-GC---WVLSEWSTCSKSCGTGSQQREAHCYLHN 1200
            .:....|::.. ..|:....|...|.  ||. .|   |.:||||.|:..||      |......:
Human   723 LSPGFDSSVYS-DLCEAAEAVRPEERKTCRNPACGPQWEMSEWSECTAKCG------ERSVVTRD 780

  Fly  1201 SRVSDD--LCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEKTRSVSC 1263
            .|.|:|  ||:|.|:|     :|..|....|         ....|.:.:||.|:..|.:.|::
Human   781 IRCSEDEKLCDPNTRP-----VGEKNCTGPP---------CDRQWTVSDWGPCSGSCGQGRTI-- 829

  Fly  1264 SHPYGIGCGSR-----------KPKDVRKC----CHIKY-TSDWTDCSVQCGEGVKRKKQSCTRV 1312
            .|.|......|           ||..:..|    |...: ..||..|:..||.|||::...|..:
Human   830 RHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMEL 894

  Fly  1313 Y--KPDV---PGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINC-KWNASDWRRCPADCSEEY 1371
            .  ||..   |.....:...:||.|..|.                | ||..|.|..|...|....
Human   895 ANGKPQTRSGPECGLAKKPPEESTCFERP----------------CFKWYTSPWSECTKTCGVGV 943

  Fly  1372 QTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQC---------------NCEG 1421
            :.|||:|  :||..:. :.||...:|..|:.|:         :..|               || .
Human   944 RMRDVKC--YQGTDIV-RGCDPLVKPVGRQACD---------LQPCPTEPPDDSCQDQPGTNC-A 995

  Fly  1422 VEKRRDFCFNSHKGRIACPTRARVERHSCTPP 1453
            :..:.:.|.:.:..:..|        .||.||
Human   996 LAIKVNLCGHWYYSKACC--------RSCRPP 1019

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931	8/28 (29%)
		TSP1	754..806	CDD:214559	12/53 (23%)
		ADAM_spacer1	937..1042	CDD:283607	35/289 (12%)
		TSP1	1172..1229	CDD:214559	20/61 (33%)
		GON	1495..1687	CDD:285848
ADAMTSL2	XP_011517543.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810