DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADAMTS1

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_008919.3	Gene:	ADAMTS1 / 9510	HGNCID:	217	Length:	967	Species:	Homo sapiens

Alignment Length:	1006	Identity:	324/1006 - (32%)
Similarity:	471/1006 - (46%)	Gaps:	192/1006 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 LNVFGRQLHLVLRQDASFV-HNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHS 361
            |:.|.:||.|.||.|:||: ...::.::. .|.|.|.|.|||:.    .|  |||||.|..||.|
Human    78 LHAFDQQLDLELRPDSSFLAPGFTLQNVG-RKSGSETPLPETDL----AH--CFYSGTVNGDPSS 135

  Fly   362 MVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEVLHRV-----------FRKSQRNARHAVSKFE 415
            ..::|||.|:.|.......|..|||:  .::.|.|...           |...:||.:..|....
Human   136 AAALSLCEGVRGAFYLLGEAYFIQPL--PAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTC 198

  Fly   416 LGLDDF---MSKLEQVQEEE----------------------QKSKSRKLNRKKRHYADVDNQVY 455
            ..:||.   ..|.|...|:|                      |.:.:..: ||||.   |.:..|
Human   199 GVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTGSI-RKKRF---VSSHRY 259

  Fly   456 TLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ----- 515
             :|.::..|.||.:|||..|:.|:|.|.|:.:.::...||.||:.:::|:::.   |:|:
Human   260 -VETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILV---IHDEQKGPE 320

  Fly   516 -THSSNEMLKHFCQFINQ-------SGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-S 571
             |.::...|::||.:..|       .....|||:|.||:.:|||   :.|..||:|::||||. |
Human   321 VTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGS---QTCDTLGMADVGTVCDPS 382

  Fly   572 SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWS 636
            .|||:::|.||..|||.||||||:.||.|||..:|   .:....|:..|:|:|::....|...||
Human   383 RSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQC---ASLNGVNQDSHMMASMLSNLDHSQPWS 444

  Fly   637 KCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEI----YSLDAQCQLSFGNDFGYCP-TDE 696
            .||.:.::.||:.....||...     |....:|||::    |..:.|||.:||.|..:|| ...
Human   445 PCSAYMITSFLDNGHGECLMDK-----PQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAAS 504

  Fly   697 ECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVS---NKHGYGRQVNGGWGPWT 758
            .|..|||..|||.. ..|.:.:.||||||.|| .|.||..||||:   .|| :....:|.||.|.
Human   505 TCSTLWCTGTSGGV-LVCQTKHFPWADGTSCG-EGKWCINGKCVNKTDRKH-FDTPFHGSWGMWG 566

  Fly   759 PFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDP-REQQCYAMNG 822
            |:..||.|||||||.:.|||:.|||:||||||.|.|.:|||||...||..:... ||:||.|.|.
Human   567 PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNE 631

  Fly   823 RNMNIPGVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGIC 883
            .:....|..|..:|:|||    .||.|||.|:......:|:|:..|.|||.|:.||...||.|.|
Human   632 FSKASFGSGPAVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQC 696

  Fly   884 RPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASN 948
            ..||||..::|..|.||||||.|...||.:::|: :.|...|.:|          :..||.||:|
Human   697 VKAGCDRIIDSKKKFDKCGVCGGNGSTCKKISGS-VTSAKPGYHD----------IITIPTGATN 750

  Fly   949 IIITQRGY----PDQNFIVLTDDRDNELLNGKF-LKTYPLKFVYAGVTMQYTGSSSVVEQVNTTY 1008
            |.:.||..    .:.:|:.:.......:|||.: |.|.....:|.||.::|:|||:.:|::. ::
Human   751 IEVKQRNQRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIR-SF 814

  Fly  1009 SWKLSRDLIVQIISLD--VSPSKRQDTVLLSYSYTIDKPPD-YEAEVEIYRWEMQAPSNCDSLCE 1070
            | .|...|.:|::::.  :.|.       :.|:|.:.|..: :.|......|.::....|...||
Human   815 S-PLKEPLTIQVLTVGNALRPK-------IKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCE 871

  Fly  1071 -GRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTRE- 1133
             |...||                               .:|| ::.....|||:.......||.
Human   872 LGWQRRL-------------------------------VECR-DINGQPASECAKEVKPASTRPC 904

  Fly  1134 KTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYL 1198
            ..:.|.|                                |.|.|||:|||:||.|.::|...|..
Human   905 ADHPCPQ--------------------------------WQLGEWSSCSKTCGKGYKKRSLKCLS 937

  Fly  1199 HNSRV-SDDLCNPRTKPHLNTLIGICNTESC 1228
            |:..| |.:.|:|..||  ...|..|....|
Human   938 HDGGVLSHESCDPLKKP--KHFIDFCTMAEC 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	36/96 (38%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/213 (35%)
		Reprolysin	457..655	CDD:279729	74/211 (35%)
		Salp15	<696..745	CDD:288931	24/51 (47%)
		TSP1	754..806	CDD:214559	32/51 (63%)
		ADAM_spacer1	937..1042	CDD:283607	29/111 (26%)
		TSP1	1172..1229	CDD:214559	23/58 (40%)
		GON	1495..1687	CDD:285848
ADAMTS1	NP_008919.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Pep_M12B_propep	66..166	CDD:279848	36/96 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	192..250		8/58 (14%)
		Cysteine switch. /evidence=ECO:0000250	196..203		0/6 (0%)
		Reprolysin	258..467	CDD:279729	77/223 (35%)
		ZnMc_ADAMTS_like	258..463	CDD:239801	75/214 (35%)
		ADAM_CR	468..548	CDD:301627	35/81 (43%)
		TSP1	562..614	CDD:214559	32/51 (63%)
		Spacer	725..849		34/143 (24%)
		ADAM_spacer1	725..842	CDD:283607	33/136 (24%)
		TSP1	858..910	CDD:214559	14/83 (17%)
		TSP1	912..967	CDD:214559	23/57 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8341
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850