DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS2

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_055059.2 Gene:ADAMTS2 / 9509 HGNCID:218 Length:1211 Species:Homo sapiens


Alignment Length:1376 Identity:360/1376 - (26%)
Similarity:534/1376 - (38%) Gaps:410/1376 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   166 CIAFLLGMLIMFHLGLRSAHKGQEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDD 230
            |.|.||.:|:               ||....|    ||..||.   .||    :...:||.|  .
Human    13 CPALLLLLLL---------------LPPPLLP----PPPPPAN---ARL----AAAADPPGG--P 49

  Fly   231 LDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQ 295
            |.........:|.:    :.::..|:......:...:.::...:|...|.::...:.|....|..
Human    50 LGHGAERILAVPVR----TDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLF 110

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAE------QRHLG-CFYSG 353
            ||:.||||.|||.||.:|..|                .||...|.:.|      :..|| |.|.|
Human   111 YNVTVFGRDLHLRLRPNARLV----------------APGATMEWQGEKGTTRVEPLLGSCLYVG 159

  Fly   354 YVED-DPHSMVSVSLCGGMTGYIKTSFGALLIQPVNR-TSSDEV----LHRVFRKSQRNARHAVS 412
            .|.. ...|.|::|.|.|:.|.|:.......|:|:.: .::.|.    :|.|:|:...:.     
Human   160 DVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSP----- 219

  Fly   413 KFELG----------LD--DFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDN 465
              .||          ||  |.:|:...|.||...|..|   |.:||.||.|   |.:|||:.||:
Human   220 --PLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR---RARRHAADDD---YNIEVLLGVDD 276

  Fly   466 SMKQFHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLI--------SLPNINDQTHSSNE 521
            |:.|||| |.:|.|:|.||:||:.|:.|.|:|..|.::|||:|        ||..|.:.:.|   
Human   277 SVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQS--- 338

  Fly   522 MLKHFCQ--FINQ---SGYE--RDTAMLITRE-----------PICGSVPGKICHMLGLAELGTV 568
             |::.|:  ::.|   :|::  .|.|:.:||:           |:.|     :||.:        
Human   339 -LENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTG-----MCHPV-------- 389

  Fly   569 CSSSSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDDKCMPYVTRQNNNKVLHIMSSVMGIHMHP 632
               .||::..:.|..:||.:|||.||:|.|.|| ..::|...|      ::..||:.::....|.
Human   390 ---RSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEV------RLGSIMAPLVQAAFHR 445

  Fly   633 WSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP---T 694
            :.||:||:..:|.:|...|  ||.....||......:|||..||::.||:..||..:..|.   |
Human   446 FHWSRCSQQELSRYLHSYD--CLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRT 508

  Fly   695 DEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTP 759
            .:.||:|||:..  ::...|.:...|..|||.|....| |.:|.|:.......:: :|.||.|:|
Human   509 FDPCKQLWCSHP--DNPYFCKTKKGPPLDGTMCAPGKH-CFKGHCIWLTPDILKR-DGSWGAWSP 569

  Fly   760 FTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRN 824
            |..||.|||.||:...|:|:.|.|.|||:.|:|....::.|:...||....|.||:||     |.
Human   570 FGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQC-----RQ 629

  Fly   825 MNIPGVNPDTK--WVPKYEKDA---CKLFCRMDMKVTYFMLKSMVTDGTSCAV-DSFDKCVNGIC 883
            .::...:.|.:  |:|...:||   |.|:|..........:|.||.|||.|:. |:|..||.|.|
Human   630 WDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDC 694

  Fly   884 RPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY-VTRIPKGAS 947
            |..|||..:.|..:.||||||.|.|..|..|.|....|          |.|..|. :..||.||.
Human   695 RKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRS----------PKKHGYIKMFEIPAGAR 749

  Fly   948 NIIITQRGYPDQNFIVLTDDRDNELLNGKFL-----------KTYPLKFVYAGVTMQYTGSSSVV 1001
            :::|.:......:..|      ..|..|||:           ||    |:..||..:|..... .
Human   750 HLLIQEVDATSHHLAV------KNLETGKFILNEENDVDASSKT----FIAMGVEWEYRDEDG-R 803

  Fly  1002 EQVNTTYSWKLSRDLIVQIISLDVSPSKRQDT-VLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNC 1065
            |.:.|  ...|...:.|.:|.:.       || |.|:|.|.|.:                     
Human   804 ETLQT--MGPLHGTITVLVIPVG-------DTRVSLTYKYMIHE--------------------- 838

  Fly  1066 DSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELG 1130
            |||                               .:||                           
Human   839 DSL-------------------------------NVDD--------------------------- 845

  Fly  1131 TREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAH 1195
                             :|:       |:.|...:|      |.|.:||.|||.||.|||..:..
Human   846 -----------------NNV-------LEEDSVVYE------WALKKWSPCSKPCGGGSQFTKYG 880

  Fly  1196 C--YLHNSRVSDDLCNPRTKPHLNTLIGICNTESC--PTYTKSPNALAVSNWVIGEWGECNEWCE 1256
            |  .|.:..|....|...:||  ..:...||.:.|  |.            ||.|||..|::.|.
Human   881 CRRRLDHKMVHRGFCAALSKP--KAIRRACNPQECSQPV------------WVTGEWEPCSQTCG 931

  Fly  1257 KT----RSVSCSHP---------YGIGCGSRKPKDVRKC----CHIKY-TSDWTDCSVQCGEGVK 1303
            :|    |||.|..|         :...|...:|:..|.|    |..:: ...|:.|||.||.|.:
Human   932 RTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQ 996

  Fly  1304 RKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRIN-CKWNASD-------- 1359
            .:...|..               .|:|:.|.:: .||:   |.::||:. |..|.||        
Human   997 ERPVLCRT---------------ADDSFGICQE-ERPE---TARTCRLGPCPRNISDPSKKSYVV 1042

  Fly  1360 -WRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKR--------------PSKRRIC------ 1403
             |...|...|      .:|..|.:|      ||...|.              |...::|      
Human  1043 QWLSRPDPDS------PIRKISSKG------HCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNL 1095

  Fly  1404 -NNCVRRQSRV 1413
             ||....:.|:
Human  1096 YNNLTNVEGRI 1106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 34/116 (29%)
ZnMc_ADAMTS_like 455..655 CDD:239801 70/227 (31%)
Reprolysin 457..655 CDD:279729 69/225 (31%)
Salp15 <696..745 CDD:288931 15/48 (31%)
TSP1 754..806 CDD:214559 22/51 (43%)
ADAM_spacer1 937..1042 CDD:283607 28/117 (24%)
TSP1 1172..1229 CDD:214559 21/60 (35%)
GON 1495..1687 CDD:285848
ADAMTS2NP_055059.2 Pep_M12B_propep 100..211 CDD:279848 36/126 (29%)
ZnMc_ADAMTS_like 266..467 CDD:239801 71/228 (31%)
Reprolysin 268..470 CDD:279729 71/229 (31%)
TSP1 564..616 CDD:214559 22/51 (43%)
Cell attachment site. /evidence=ECO:0000255 691..693 0/1 (0%)
Spacer 723..851 41/260 (16%)
ADAM_spacer1 723..837 CDD:283607 33/143 (23%)
TSP1 863..914 CDD:214559 18/52 (35%)
TSP1 917..976 CDD:214559 17/70 (24%)
TSP1 982..1029 CDD:214559 16/65 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1170..1191
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR13723
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.870

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