DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADAMTS4

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_001307265.1	Gene:	ADAMTS4 / 9507	HGNCID:	220	Length:	846	Species:	Homo sapiens

Alignment Length:	663	Identity:	240/663 - (36%)
Similarity:	332/663 - (50%)	Gaps:	99/663 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 LNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSM 362
            |..||..|.|.|.|| |.|....:| ::.|.:     .||....||.   |.:.:|.:..||.|:
Human    85 LQAFGETLLLELEQD-SGVQVEGLT-VQYLGQ-----APELLGGAEP---GTYLTGTINGDPESV 139

  Fly   363 VSVSLCGG-MTGYIKTSFGALLIQPVN----RTSSDEVLHRVFRKSQRNARHAVS--KFELGLDD 420
            .|:...|| :.|.::.....|.:||:.    .::.....|.:.|||..:.:..:.  |..||
Human   140 ASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLG--- 201

  Fly   421 FMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSI 485
                          |.|.:..|.|| :|.:...|   |.|:..|:.|..|||..|:.|:|.:|:.
Human   202 --------------SPSPRPRRAKR-FASLSRFV---ETLVVADDKMAAFHGAGLKRYLLTVMAA 248

  Fly   486 VSSIFADASIGNSIRILLVRLISL------PNINDQTHSSNEMLKHFCQFINQSGYER------- 537
            .:..|...||.|.:.:::.||:.|      |.:..   |:.:.|:.||.:  |.|...
Human   249 AAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGP---SAAQTLRSFCAW--QRGLNTPEDSDPD 308

  Fly   538 --DTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMN 599
              |||:|.||:.:||.   ..|..||:|::||||. :.||:||:|.||.:|||.||||||:.||.
Human   309 HFDTAILFTRQDLCGV---STCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 370

  Fly   600 HDDDDKCM----PYVTRQNNNKVLHIMSSVMGIHMHPWS-WSKCSRHFVSEFLEKTDKSCL--ET 657
            ||:...|:    |..|.:      |:|:.||. |:.|.. ||.||..|:::||:.....||  :.
Human   371 HDNSKPCISLNGPLSTSR------HVMAPVMA-HVDPEEPWSPCSARFITDFLDNGYGHCLLDKP 428

  Fly   658 SVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP-TDEECKRLWCNRTSG--NSNEQCASSNL 719
            ....|:|.   ..||:.|..|.||||:||.|..:|| ....|..|||   ||  |.:..|.:.:.
Human   429 EAPLHLPV---TFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWC---SGHLNGHAMCQTKHS 487

  Fly   720 PWADGTPCGSSGHWCQRGKC--VSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPV 782
            |||||||||.: ..|..|:|  :.....:.....||||||.|:..||.|||||||.|.|:|.:||
Human   488 PWADGTPCGPA-QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPV 551

  Fly   783 PENGGKYCTGSRKKYRSCNTHQCPPGS-MDPREQQCYAMNGRN---MNIPGVNPDTKWVPKY--- 840
            |.||||||.|.|.::|||||..||.|| :..||:||.|.|.|.   .:.||   ...|||:|
Human   552 PRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPG---PMDWVPRYTGV 613

  Fly   841 -EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVC 904
             .:|.|||.|:......|::|:..|.|||.|:.||...||.|.|..||||..:.|..|.|||.||
Human   614 APQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVC 678

  Fly   905 EGRNDTCHEVTGN 917
            .|....|.:.:|:
Human   679 GGDGSGCSKQSGS 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	28/100 (28%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	77/220 (35%)
		Reprolysin	457..655	CDD:279729	77/218 (35%)
		Salp15	<696..745	CDD:288931	20/52 (38%)
		TSP1	754..806	CDD:214559	33/51 (65%)
		ADAM_spacer1	937..1042	CDD:283607
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
ADAMTS4	NP_001307265.1	Pep_M12B_propep	70..181	CDD:279848	29/105 (28%)
		Cysteine switch. /evidence=ECO:0000250	192..199		1/6 (17%)
		Reprolysin	218..428	CDD:279729	80/227 (35%)
		ZnMc_ADAMTS_like	218..425	CDD:239801	79/224 (35%)
		ADAM_CR	438..509	CDD:301627	33/74 (45%)
		ADAM_CR	490..659	CDD:301627	80/172 (47%)
		TSP1	531..575	CDD:214559	28/43 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8341
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820