Protein Alignment AdamTS-A and ADAMTS4

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: NP_001307265.1
• Gene: ADAMTS4 / 9507
• HGNCID: 220
• Length: 846
• Species: Homo sapiens
• Alignment Length: 663
• Identity: 240/663 - (36%)
• Similarity: 332/663 - (50%)
• Gaps: 99/663 - (14%)

  Fly   298 LNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSM 362
            |..||..|.|.|.|| |.|....:| ::.|.:     .||....||.   |.:.:|.:..||.|:
Human    85 LQAFGETLLLELEQD-SGVQVEGLT-VQYLGQ-----APELLGGAEP---GTYLTGTINGDPESV 139

  Fly   363 VSVSLCGG-MTGYIKTSFGALLIQPVN----RTSSDEVLHRVFRKSQRNARHAVS--KFELGLDD 420
            .|:...|| :.|.::.....|.:||:.    .::.....|.:.|||..:.:..:.  |..||
Human   140 ASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLG--- 201

  Fly   421 FMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSI 485
                          |.|.:..|.|| :|.:...|   |.|:..|:.|..|||..|:.|:|.:|:.
Human   202 --------------SPSPRPRRAKR-FASLSRFV---ETLVVADDKMAAFHGAGLKRYLLTVMAA 248

  Fly   486 VSSIFADASIGNSIRILLVRLISL------PNINDQTHSSNEMLKHFCQFINQSGYER------- 537
            .:..|...||.|.:.:::.||:.|      |.:..   |:.:.|:.||.:  |.|...
Human   249 AAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGP---SAAQTLRSFCAW--QRGLNTPEDSDPD 308

  Fly   538 --DTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMN 599
              |||:|.||:.:||.   ..|..||:|::||||. :.||:||:|.||.:|||.||||||:.||.
Human   309 HFDTAILFTRQDLCGV---STCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 370

  Fly   600 HDDDDKCM----PYVTRQNNNKVLHIMSSVMGIHMHPWS-WSKCSRHFVSEFLEKTDKSCL--ET 657
            ||:...|:    |..|.:      |:|:.||. |:.|.. ||.||..|:::||:.....||  :.
Human   371 HDNSKPCISLNGPLSTSR------HVMAPVMA-HVDPEEPWSPCSARFITDFLDNGYGHCLLDKP 428

  Fly   658 SVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP-TDEECKRLWCNRTSG--NSNEQCASSNL 719
            ....|:|.   ..||:.|..|.||||:||.|..:|| ....|..|||   ||  |.:..|.:.:.
Human   429 EAPLHLPV---TFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWC---SGHLNGHAMCQTKHS 487

  Fly   720 PWADGTPCGSSGHWCQRGKC--VSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPV 782
            |||||||||.: ..|..|:|  :.....:.....||||||.|:..||.|||||||.|.|:|.:||
Human   488 PWADGTPCGPA-QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPV 551

  Fly   783 PENGGKYCTGSRKKYRSCNTHQCPPGS-MDPREQQCYAMNGRN---MNIPGVNPDTKWVPKY--- 840
            |.||||||.|.|.::|||||..||.|| :..||:||.|.|.|.   .:.||   ...|||:|
Human   552 PRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPG---PMDWVPRYTGV 613

  Fly   841 -EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVC 904
             .:|.|||.|:......|::|:..|.|||.|:.||...||.|.|..||||..:.|..|.|||.||
Human   614 APQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVC 678

  Fly   905 EGRNDTCHEVTGN 917
            .|....|.:.:|:
Human   679 GGDGSGCSKQSGS 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	28/100 (28%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	77/220 (35%)
		ADAMTS_CR_2	671..740	CDD:465496	33/73 (45%)
		TSP1	754..806	CDD:214559	33/51 (65%)
		ADAMTS_CR_3	815..911	CDD:437068	41/102 (40%)
		TSP1	1172..1229	CDD:214559
		TSP1_ADAMTS	1243..1282	CDD:465950
		TSP1_ADAMTS	1355..1405	CDD:465950
		GON	1493..1687	CDD:462559
ADAMTS4	NP_001307265.1	Pep_M12B_propep	60..181	CDD:460254	29/105 (28%)
		Cysteine switch. /evidence=ECO:0000250	192..199		1/6 (17%)
		ZnMc_ADAMTS_like	218..425	CDD:239801	79/224 (35%)
		ADAMTS_CR_2	439..507	CDD:465496	32/71 (45%)
		TSP1	531..575	CDD:214559	28/43 (65%)
		ADAMTS_CR_3	578..685	CDD:437068	44/109 (40%)