DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and PAPLN

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_001352835.1 Gene:PAPLN / 89932 HGNCID:19262 Length:1278 Species:Homo sapiens


Alignment Length:843 Identity:203/843 - (24%)
Similarity:298/843 - (35%) Gaps:195/843 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   748 RQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDP 812
            |:.:..||||:.::|||.||||||....|.|... ..:||..|.|..:.:|||.|..||.|:.|.
Human    23 RRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQ-RRDGGSSCVGPARSHRSCRTESCPDGARDF 86

  Fly   813 REQQCYAMNGRNMNIPGVNPDTKWVPKYE-KDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFD 876
            |.:||...:|....    ....:|:|.|. .:.|:|.|....:..|:..:..|.|||.|.....|
Human    87 RAEQCAEFDGAEFQ----GRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKRD 147

  Fly   877 KCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTR 941
            .||:|.||..|||:||:|..:.|||..|.|...||:.|.|..         |.|:.::....:..
Human   148 VCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF---------DANDLSRGYNQILI 203

  Fly   942 IPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQY-TGSSSVVEQVN 1005
            :|.||::|:|.:.. ..:||:.:.:.|....|||.:..........|...:.| .|:...:....
Human   204 VPMGATSILIDEAA-ASRNFLAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPER 267

  Fly  1006 TTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKP-PDYEAEVEIYRWEMQAPSNCDSLC 1069
            .......|..|::::||.:.:|.     |...|...:.:| |.:.       |...:.|:|.:.|
Human   268 LHARGPTSEPLVIELISQEPNPG-----VHYEYHLPLRRPSPGFS-------WSHGSWSDCSAEC 320

  Fly  1070 -EGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNT-DC--RLNLTVTSISECSAACGELG 1130
             .|...||..|  |..........|.:...| .|.|:||. .|  .........:.|||:||. |
Human   321 GGGHQSRLVFC--TIDHEAYPDHMCQRQPRP-ADRRSCNLHPCPETKRWKAGPWAPCSASCGG-G 381

  Fly  1131 TREKTYACVQT-FTNMQRSNIVDMSYCK-LKFDVAYHEEC---REGCWVLSEWSTCSKSCGTGSQ 1190
            ::.::..|:.: ...:|.:  |:.:.|. |.......:.|   |...|....|..||.|||.|.:
Human   382 SQSRSVYCISSDGAGIQEA--VEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVR 444

  Fly  1191 QREAHC------YLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWG 1249
            :|...|      .||.:..|.:...|.|:|        |..|.||       .|:...|.:|.||
Human   445 KRSVTCRGERGSLLHTAACSLEDRPPLTEP--------CVHEDCP-------LLSDQAWHVGTWG 494

  Fly  1250 ECNEWCE---KTRSVSC-----SHPYGIGCGS---RKPKDVRKC----CHIKY------------ 1287
            .|::.|.   :.|.|.|     ||     |||   .||.||..|    ||:..            
Human   495 LCSKSCSSGTRRRQVICAIGPPSH-----CGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPA 554

  Fly  1288 TSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRR---VYVDESYCISRKVHRPKLRTTTKSC 1349
            ::.|.....|.......:.|.......|...|..:..   ...|:...:|.....|.|:......
Human   555 SNPWMPLGPQESPASDSRGQWWAAQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQ 619

  Fly  1350 RINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVI 1414
            .:.......|.|..|..|..:..|..:. ..:||                               
Human   620 PLRSGSGPHDCRHSPHGCCPDGHTASLG-PQWQG------------------------------- 652

  Fly  1415 SQCNCEGVEKRRDFCFNSHKGRIACPTRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSR 1479
                |.|..     |..|..|  .||.|.                     |::..|...|.:   
Human   653 ----CPGAP-----CQQSRYG--CCPDRV---------------------SVAEGPHHAGCT--- 682

  Fly  1480 SLNSIGGSRNRGTPRSCADLKEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQE 1542
              .|.||....|.|||.|....:|                        |:..||...| :|.|
Human   683 --KSYGGDSTGGMPRSRAVASTVH------------------------NTHQPQAQQN-EPSE 718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848
ZnMc_ADAMTS_like 455..655 CDD:239801
Reprolysin 457..655 CDD:279729
Salp15 <696..745 CDD:288931
TSP1 754..806 CDD:214559 23/51 (45%)
ADAM_spacer1 937..1042 CDD:283607 21/105 (20%)
TSP1 1172..1229 CDD:214559 18/62 (29%)
GON 1495..1687 CDD:285848 9/48 (19%)
PAPLNNP_001352835.1 TSP1 29..80 CDD:214559 23/51 (45%)
ADAM_spacer1 183..298 CDD:310520 25/129 (19%)
TSP1 308..361 CDD:214559 15/55 (27%)
TSP1 369..424 CDD:214559 12/57 (21%)
TSP1 424..481 CDD:214559 18/64 (28%)
TSP1 488..539 CDD:214559 19/55 (35%)
Kunitz_BPTI 753..805 CDD:278443
Papilin_u7 814..905 CDD:318767
Ig 914..>978 CDD:325142
I-set 1049..1119 CDD:254352
IG 1139..1219 CDD:214652
PLAC 1235..1267 CDD:312271
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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