DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS10

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_112219.3 Gene:ADAMTS10 / 81794 HGNCID:13201 Length:1103 Species:Homo sapiens


Alignment Length:1281 Identity:356/1281 - (27%)
Similarity:511/1281 - (39%) Gaps:324/1281 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 ACCI---AFLLGMLIMFHLGLRSAHKGQEELPQSTHP---------------LANSPPATPATLH 210
            ||.|   |..||:.:||.  :..|.:.|:|...|...               ||.|||.      
Human     4 ACQILRWALALGLGLMFE--VTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPP------ 60

  Fly   211 PRRLDNDTSTDHEPPDGLDDLDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASA 275
            |||....|.                             :.:|:.|.|:....| .:..|..:.|:
Human    61 PRRQRRGTG-----------------------------ATAESRLFYKVASPS-THFLLNLTRSS 95

  Fly   276 FAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEA 340
            ..:.|   ::|.|.|                                    .:||      ....
Human    96 RLLAG---HVSVEYW------------------------------------TREG------LAWQ 115

  Fly   341 EAEQRHLGCFYSGYVEDDPHSM-VSVSLCGGMTGYIKTSFGALLIQPV------NRTSSDEVLHR 398
            .|.:.|  |.|:|:::....|. |::|.|||:.|.|.......||:|:      :|:..:...|.
Human   116 RAARPH--CLYAGHLQGQASSSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHV 178

  Fly   399 VFRKSQRNARHAVSKFELGLDD---------FMSKLE--------QVQEEEQKSKSRKLNRKKRH 446
            |:::|  :.||.......|:.|         ::..|:        ...|..|....|.::|::  
Human   179 VYKRS--SLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRER-- 239

  Fly   447 YADVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLP 510
                     .:|.|:..|..|..:|| .|::.|:|.:|:||:.:|.|:|:|:::.||:.|||.| 
Human   240 ---------YVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILL- 294

  Fly   511 NINDQ-----THSSNEMLKHFCQF----INQSGY----------ERDTAMLITREPICGSVPGKI 556
             ..||     ||.:.:.|..||::    :|.||:          ..|||:||||..|| ....|.
Human   295 -TEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDIC-IYKNKP 357

  Fly   557 CHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHD-----------DDDKCM-P 608
            |..||||.:|.:|. ..|||:.:|.||.||||:|||:||...||||           |..|.| .
Human   358 CGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLMAA 422

  Fly   609 YVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAH-IPYGTERLPG 672
            ::|.:.|                |:.||.|||.:::.||:.....||....... ..|.|. .||
Human   423 HITMKTN----------------PFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTV-APG 470

  Fly   673 EIYSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGH----- 732
            :.|..|.||:...|.....|...|.|..|||.    :.:.:|.::::|.|:||.|.:  |     
Human   471 QAYDADEQCRFQHGVKSRQCKYGEVCSELWCL----SKSNRCITNSIPAAEGTLCQT--HTIDKG 529

  Fly   733 WCQRGKCV---SNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSR 794
            ||.:..||   |...|    |:|.||||||:..||.||||||..|.|.|:.|.|..|||||.|.|
Human   530 WCYKRVCVPFGSRPEG----VDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGER 590

  Fly   795 KKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE---KDACKLFCRMDMKVT 856
            :::|||||..|||||.|.||.||...:    :||......|| ..|.   ..||.|.|..:....
Human   591 RRHRSCNTDDCPPGSQDFREVQCSEFD----SIPFRGKFYKW-KTYRGGGVKACSLTCLAEGFNF 650

  Fly   857 YFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVS 921
            |....:.|.|||.|..|:.|.||:|.|:..|||..|.|..:.|||.||.|....|..:.|....:
Human   651 YTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSPA 715

  Fly   922 NLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNF----IVLTDDRDNELLNGKFLKTYP 982
            :         |......|..||||:.:|.|     .|.|.    :.|..|:::.||.|......|
Human   716 S---------PGAGYEDVVWIPKGSVHIFI-----QDLNLSLSHLALKGDQESLLLEGLPGTPQP 766

  Fly   983 LKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI----- 1042
            .:...||.|.|.......|:.:...  ..::..|||.:::       |.:...|.|.:..     
Human   767 HRLPLAGTTFQLRQGPDQVQSLEAL--GPINASLIVMVLA-------RTELPALRYRFNAPIARD 822

  Fly  1043 DKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSH-RLPACISTTQGVKVAPQFCD-KSAMPKIDDRA 1105
            ..||        |.|.....:.|.:.|.|.|. :...|.:......|||.:|. .|.:|| ..||
Human   823 SLPP--------YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPK-RQRA 878

  Fly  1106 CNTD-CRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECR 1169
            |||: |..:..|.:.|.||.:| :.|.|.::..| |...:......:|.|.|...     .....
Human   879 CNTEPCPPDWVVGNWSLCSRSC-DAGVRSRSVVC-QRRVSAAEEKALDDSACPQP-----RPPVL 936

  Fly  1170 EGC--------WVLSEWSTCSKSCGTGSQQREAHCYL--HNSRVSDDLCNPRTKPHLNTLIGICN 1224
            |.|        |...:||.|:.|||.|.:.|...|..  |.:.:....|:|..||.....   ||
Human   937 EACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMR---CN 998

  Fly  1225 TESCPTYTKSPNALAVSNWVIGEWGECNEWC---EKTRSVSCSHPYGIGCGSRKPKDVRKCCHIK 1286
            ...||.          :.||.||||||:..|   ::.|||.|:        |...:...:|....
Human   999 LRRCPP----------ARWVAGEWGECSAQCGVGQRQRSVRCT--------SHTGQASHECTEAL 1045

  Fly  1287 YTSDWTDCSVQC-----GEGVKR--------------KKQSCTRVY 1313
            .......|..:|     |:|.:.              |.|.|:|.|
Human  1046 RPPTTQQCEAKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAY 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 22/114 (19%)
ZnMc_ADAMTS_like 455..655 CDD:239801 81/232 (35%)
Reprolysin 457..655 CDD:279729 81/230 (35%)
Salp15 <696..745 CDD:288931 17/56 (30%)
TSP1 754..806 CDD:214559 31/51 (61%)
ADAM_spacer1 937..1042 CDD:283607 26/108 (24%)
TSP1 1172..1229 CDD:214559 18/66 (27%)
GON 1495..1687 CDD:285848
ADAMTS10NP_112219.3 Pep_M12B_propep 73..179 CDD:279848 30/153 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..233 2/19 (11%)
Reprolysin 239..457 CDD:279729 83/247 (34%)
ZnMc_ADAMTS_like 239..454 CDD:239801 82/244 (34%)
TSP1 550..602 CDD:214559 31/51 (61%)
Spacer 706..828 30/152 (20%)
ADAM_spacer1 706..818 CDD:283607 28/134 (21%)
TSP1 829..885 CDD:214559 18/56 (32%)
TSP1 952..1003 CDD:214559 16/53 (30%)
TSP1 1010..1054 CDD:214559 13/51 (25%)
PLAC 1069..1100 CDD:285849 5/23 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100241
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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