DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADAMTS12

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_016865394.1	Gene:	ADAMTS12 / 81792	HGNCID:	14605	Length:	1631	Species:	Homo sapiens

Alignment Length:	1687	Identity:	383/1687 - (22%)
Similarity:	582/1687 - (34%)	Gaps:	615/1687 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 DLDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDIN-SFLKESASAFAMTGTYRNMSNEIWDPH 293
            |||..|...:      |..|..|.||.:    |..:| .||..|   :.|...|.|:|
Human    83 DLDGSEDWVY------YRISHEEKDLFF----NLTVNQGFLSNS---YIMEKRYGNLS------- 127

  Fly   294 PQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYV--E 356
                                         |::::              |....| |..||.|  :
Human   128 -----------------------------HVKMM--------------ASSAPL-CHLSGTVLQQ 148

  Fly   357 DDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNR---TSSDEVLHRVFRKSQRNARHAVSKFE--- 415
            .......::|.|.|:||:.:...|...|:||.:   .......|.|:|      |..|.:.:
Human   149 GTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHPHIVYR------RQKVPETKEPT 207

  Fly   416 LGLDDFMSKLEQVQE------EEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-E 473
            .||.|.:: :.|.||      |.....||.|:|:     .:..:.: :|.|:..|..|.::|| |
Human   208 CGLKDSVN-ISQKQELWREKWERHNLPSRSLSRR-----SISKERW-VETLVVADTKMIEYHGSE 265

  Fly   474 DLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ----THSSNEMLKHFCQF---IN 531
            :::.|||.:|::|:.:|.:.||||:|.|::||||.|.. .:|    .|.:.:.|..||::   ||
Human   266 NVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEE-EEQGLKIVHHAEKTLSSFCKWQKSIN 329

  Fly   532 QSG----YERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHE 591
            ...    ...|.|:|:||:.||... .:.|..|||:.|..:|. ..||:|.:|:|||.|||:|||
Human   330 PKSDLNPVHHDVAVLLTRKDICAGF-NRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHE 393

  Fly   592 LGHILNMNHD-DDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL 655
            |||...:.|| .::.|.| |.|..     :|||..:.....|.:|||||..:::.||::....||
Human   394 LGHSFGIQHDGKENDCEP-VGRHP-----YIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCL 452

  Fly   656 ETSVGAHIP--YGTER---LPGEIYSLDAQCQLSFGNDFGYCPTDEE-CKRLWCNRTSGNSNEQC 714
            :     .||  .|.:.   .||.||.:..||||.:|.:..:|...|. |:.|||: ..|    .|
Human   453 D-----DIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCS-VKG----FC 507

  Fly   715 ASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQ---VNGGWGPWTPFTPCSLTCGGGVQESRR 776
            .|.....||||.||.. .||..|||::    .|::   :.||||.|:|::.||.|||.|||.:.|
Human   508 RSKLDAAADGTQCGEK-KWCMAGKCIT----VGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAER 567

  Fly   777 ECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE 841
            .||.|.|:.|||||||.||:||.||.|.|...:...|:.||...:    .:|..|....|.|.:.
Human   568 LCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFD----TVPYKNELYHWFPIFN 628

  Fly   842 -KDACKLFCR-MDMKVTYFMLKSMVTDGTSC--AVDSFDKCVNGICRPAGCDNELNSIAKLDKCG 902
             ...|:|:|| :|.:.:..||.::: |||.|  ..:|.:.|:||||:..|||.|::|.|..|:||
Human   629 PAHPCELYCRPIDGQFSEKMLDAVI-DGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCG 692

  Fly   903 VCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQ---RGYPDQNFIVL 964
            ||.|...:|..|..........|..|          :..|||||.:|.:.:   .|    ||:.:
Human   693 VCLGDGSSCQTVRKMFKQKEGSGYVD----------IGLIPKGARDIRVMEIEGAG----NFLAI 743

  Fly   965 -TDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPS 1028
             ::|.:...|||.|:..:...:..||...||.....:.:.:.|   ...:..:.:|::....:|.
Human   744 RSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYDRKGDLEKLMAT---GPTNESVWIQLLFQVTNPG 805

  Fly  1029 KRQDTVLLSYSYTIDKPP-DYEAEVEIYRWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQ 1091
                   :.|.|||.|.. |.:.|.::|.|:....:.|...| .|...:...||...:|: |...
Human   806 -------IKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGM-VKAT 862

  Fly  1092 FCDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSY 1155
            |||....|....:.|:.. |...........|||.||..|.:::|..|:||..:.:::  :..:.
Human   863 FCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQA--LPPTD 925

  Fly  1156 CKLKFDVAYHEECREG--C---WVLSEWS------------------------------------ 1179
            |:..........|...  |   |.:..||
Human   926 CQHLLKPKTLLSCNRDILCPSDWTVGNWSELHWLGPNTVRHSFSCTFSCAHSICFSKELISQSCF 990

  Fly  1180 -TCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCP-------------- 1229
             :||.|||.|.:.|...|    ::..|:.|:...||:...|   |..:.||
Human   991 TSCSVSCGGGVRIRSVTC----AKNHDEPCDVTRKPNSRAL---CGLQQCPSSRRVLKPNKGTIS 1048

  Fly  1230 ----------------------------------------------------------------- 1229

Human  1049 NGKNPPTLKPVPPPTSRPRMLTTPTGPESMSTSTPAISSPSPTTASKEGDLGGKQWQDSSTQPEL 1113

  Fly  1230 ----------------------------------------------------------------- 1229

Human  1114 SSRYLISTGSTSQPILTSQSLSIQPSEENVSSSDTGPTSEGGLVATTTSGSGLSSSRNPITWPVT 1178

  Fly  1230 ----TYTKSP------------------------------------------------------- 1235
                |.||.|
Human  1179 PFYNTLTKGPEMEIHSGSGEEREQPEDKDESNPVIWTKIRVPGNDAPVESTEMPLAPPLTPDLSR 1243

  Fly  1236 ------------------------------------------------------------NALAV 1240
                                                                        |.|.:
Human  1244 ESWWPPFSTVMEGLLPSQRPTTSETGTPRVEGMVTEKPANTLLPLGGDHQPEPSGKTANRNHLKL 1308

  Fly  1241 SN-------------------------------------------WVIGEWGECNEWC---EKTR 1259
            .|                                           |::|.|.||:..|   ...|
Human  1309 PNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWR 1373

  Fly  1260 SVSCSHPYGIGCGSRKPKDVRKCCHIK-----YTSDWTDCSVQCGEGVKRKKQSCT-----RVYK 1314
            .|.||......|.:.:..|..|.||::     ...:|:.||..|..|.|.::..|.     |..:
Human  1374 RVECSTQMDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLR 1438

  Fly  1315 P-------DVP-----------------------------GTRKRRVYVDESYCISRKVHRPKLR 1343
            |       .:|                             |.::|.|:.....|...|  ||
Human  1439 PFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGLCDWTK--RP--- 1498

  Fly  1344 TTTKSC--RINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKH---CDAKKRPSKRRIC 1403
            |:|.||  .:.|.|...:|..|...|...:|.|.|:|...:|:..||:.   ||.|.||.:.:.|
Human  1499 TSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKC 1563

  Fly  1404 NNCVRRQS------------------RVISQCNCEGVEKRRDFCFNSHKGRIACPTRARVER 1447
            |....::|                  :.:.:|:...|  |.:.||:..:..|....|.|.:|
Human  1564 NQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTV--RAECCFSCPQTHITHTQRQRRQR 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	17/112 (15%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	77/213 (36%)
		Reprolysin	457..655	CDD:279729	77/211 (36%)
		Salp15	<696..745	CDD:288931	19/49 (39%)
		TSP1	754..806	CDD:214559	31/51 (61%)
		ADAM_spacer1	937..1042	CDD:283607	23/108 (21%)
		TSP1	1172..1229	CDD:214559	18/96 (19%)
		GON	1495..1687	CDD:285848
ADAMTS12	XP_016865394.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720