DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTS20

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_011537056.1 Gene:ADAMTS20 / 80070 HGNCID:17178 Length:1911 Species:Homo sapiens


Alignment Length:1917 Identity:542/1917 - (28%)
Similarity:774/1917 - (40%) Gaps:586/1917 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   286 SNEIWDPHP---QYNLNVFGRQLHLVLRQDASFV-HNHSMTHIRILKEG--EEHPGPETEAEAEQ 344
            |:|..:|.|   .|....:|:...|.|..||||: ..::..|:...:.|  |...||     ::.
Human    67 SSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGP-----SDL 126

  Fly   345 RHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEV------LHRVFRKS 403
            ||  |||.|.|.........||||||:||..|...|...::|:.:...:|.      .|.::|:.
Human   127 RH--CFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQD 189

  Fly   404 QRNARHAVSKF---------ELGL---------DDFMSKLEQVQEEEQKS----KSRKLNRKKR- 445
            ..|:.....|:         |..|         :|.....|:|.....|:    ..|:.:|||| 
Human   190 LNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRL 254

  Fly   446 ----HYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRL 506
                .|         :|:::..|..:...||.:||.|||.|||||::|:.|.||||.|.|::|:|
Human   255 ISYPRY---------IEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKL 310

  Fly   507 ISL------PNINDQTHSSNEMLKHFCQF---------INQSGYERDTAMLITREPICGSVPGKI 556
            :.:      |.||   ......||:||.:         ::.|  ..|||:|||||.||.|  .:.
Human   311 VMIHREEEGPVIN---FDGATTLKNFCSWQQTQNDLDDVHPS--HHDTAVLITREDICSS--KEK 368

  Fly   557 CHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPY-VTRQNNNKVL 619
            |:||||:.|||:|.. .||.|.::.||.:|||:||||||.|.:.|||:.:|... ||:      .
Human   369 CNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTK------Y 427

  Fly   620 HIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLS 684
            |:|:..:..||.|||||.|||.:|:|||:.....||.......|......|||..|..:.||:|:
Human   428 HVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELA 492

  Fly   685 FGNDFGYCPTDEE-CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGR 748
            ||.....||..|. |..|||..|. ..::.|.:.::|.||||.||...| |:.|.|| ||....|
Human   493 FGPGSQMCPHIENICMHLWCTSTE-KLHKGCFTQHVPPADGTDCGPGMH-CRHGLCV-NKETETR 554

  Fly   749 QVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPR 813
            .|||.||||.|::.||.|||||::.:.|.||:|.|.|||.||.|.|.|:|||||..||.|:.|.|
Human   555 PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFR 619

  Fly   814 EQQCYAMNGRNMNIPGVNPDTKWVPKYE----KDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDS 874
            |:||...||::::|.|:..:.:|:|:|.    ||.|||:|::.....:::||.||.|||.|..::
Human   620 EKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTET 684

  Fly   875 FDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYV 939
            .|.||.|.|..||||:.|||.||:||||||.|.|.:|..:|| :..|:..|.|          .|
Human   685 HDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITG-VFNSSHYGYN----------VV 738

  Fly   940 TRIPKGASNIIITQRGY---PDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVT---MQYTGSS 998
            .:||.||:|:.|.|..|   ||.:::.|:|...|.|.||.||.:...|.:....|   ::|:||:
Human   739 VKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSN 803

  Fly   999 SVVEQVNTTYSWKLSRDLIVQIISLD--VSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQA 1061
            :.||::|:|.  :..::||:|::.:.  .:|.       :.||:.|    ..|...:::.|:...
Human   804 NAVERINSTN--RQEKELILQVLCVGNLYNPD-------VHYSFNI----PLEERSDMFTWDPYG 855

  Fly  1062 P-SNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAA 1125
            | ..|..:|:|...|...||..:....|:.:.||...:|....::|||||.|...|...||||:.
Human   856 PWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQ 920

  Fly  1126 CGELGTREKTYACVQTFTNMQRSNIVDMSYC--KLK-----------FDVAYH------------ 1165
            ||: |.|.....|::...:..::..||..||  :||           ....:|            
Human   921 CGQ-GYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCG 984

  Fly  1166 --------------------EEC-------REGC-------WVLSEWSTCSKSCGTGSQQREAHC 1196
                                .||       ||.|       |..||||.|..:||.|::||:..|
Human   985 GGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWC 1049

  Fly  1197 YLHNSRVSDDLCNPRTKP------HLNTLI-------GICNT----------------------- 1225
            .|:...:||..||..|||      .|:|..       |.|.|                       
Human  1050 QLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLE 1114

  Fly  1226 -------------ESC----------------PT----------------------------YTK 1233
                         :||                ||                            |..
Human  1115 DTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVS 1179

  Fly  1234 SPNAL-----------------------AVSNWVIGEWGECNEWC---EKTRSVSC--------- 1263
            ..:||                       ....|..|:|..|:..|   :.||.|.|         
Human  1180 CRDALDRIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDE 1244

  Fly  1264 ------------------------SH--------------------------------------- 1265
                                    ||                                       
Human  1245 NYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQW 1309

  Fly  1266 ---PYGIGCGS---------------------------RKPKDVRKC----CHIKYTSDWTDCSV 1296
               |:| .|.|                           .||.::::|    |......:|.:||.
Human  1310 RTGPWG-SCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQ 1373

  Fly  1297 QCGEGVKRK-------------KQSCTRVYKP-------------DV-----PGTR------KRR 1324
            .||.|:|.:             ..:|..|.||             ||     |.|.      |.|
Human  1374 TCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGR 1438

  Fly  1325 VYVDESYCISR-----------KVHRPKLRTTTKSCR-INC-KWNASDWRRCPADCSEEYQTRDV 1376
            .| .|.:||.:           :|.:|   .|.|:|| :.| .|.|:.|..|...|....|.|||
Human  1439 KY-REVFCIDQFQRKLEDTNCSQVQKP---PTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDV 1499

  Fly  1377 RCESFQGDG-VEDKHCDAKKRPSKRRIC--NNCVRRQSRVISQCNCEGVEKRRDFCFNSHKGRIA 1438
            .|. .:|.| |.::.||...||..:|.|  .:||:.:.....:.||....:|:|    ||: |:.
Human  1500 YCR-LKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKD----SHQ-RME 1558

  Fly  1439 C--------------PTRARVERHSCTPPP---------------HC----RRRSAIGSSISS-- 1468
            |              .:...:...:|..||               :|    |:|....:.|.|  
Human  1559 CTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTK 1623

  Fly  1469 -------RP---------------------------------------------------RGTGV 1475
                   ||                                                   ...|:
Human  1624 KHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGL 1688

  Fly  1476 SSSRSLNSI-GGSRNRGTPRSCADL---KEMHGYN---KDGNYQLEVRSRMVHIYCHGMNSRTPQ 1533
            ||...||.: .|::.:.....|...   ||:...|   |||:|.|.::.|::.|||..|....|:
Human  1689 SSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQVKNHIRKDGDYYLNIKGRIIKIYCADMYLENPK 1753

  Fly  1534 EYVN-VDPQENYSIYYEYRTKQTNSCPPESRGHEYYNDQN----SGRTHFRKLRLNITDLRIMDN 1593
            ||:. |..:||:|..|.:|.|....||......|.....|    :|.|.|.|:|:::|.::|...
Human  1754 EYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDNGHLAAGYTVFSKIRIDLTSMQIKTT 1818

  Fly  1594 DFKFADS-RGLAQKLGSAGDCYNRIGQCPQGDFSINMKDTDFSIRPGTVWRMHGQY-SVMKRISE 1656
            |..|:.: .|.|....:|||||:.. :||||.||||:..|...|.....|...|.| ||..|.||
Human  1819 DLLFSKTIFGNAVPFATAGDCYSAF-RCPQGQFSINLSGTGMKISSTAKWLTQGSYTSVSIRRSE 1882

  Fly  1657 FDTTTQMRRGFCGGYCGGCYIAPDSGLYLDVL 1688
             |.|...  |.||||||.|.....:||.:.|:
Human  1883 -DGTRFF--GKCGGYCGKCLPHMTTGLPIQVI 1911

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 35/113 (31%)
ZnMc_ADAMTS_like 455..655 CDD:239801 89/216 (41%)
Reprolysin 457..655 CDD:279729 89/214 (42%)
Salp15 <696..745 CDD:288931 21/49 (43%)
TSP1 754..806 CDD:214559 30/51 (59%)
ADAM_spacer1 937..1042 CDD:283607 34/112 (30%)
TSP1 1172..1229 CDD:214559 28/128 (22%)
GON 1495..1687 CDD:285848 74/204 (36%)
ADAMTS20XP_011537056.1 Pep_M12B_propep 64..185 CDD:279848 37/124 (30%)
Reprolysin 259..467 CDD:279729 92/229 (40%)
ZnMc_ADAMTS_like 259..464 CDD:239801 91/226 (40%)
TSP1 560..612 CDD:214559 30/51 (59%)
ADAM_spacer1 722..841 CDD:283607 40/142 (28%)
TSP1 971..1024 CDD:214559 6/52 (12%)
TSP1 1029..1078 CDD:214559 20/48 (42%)
TSP1 1081..1136 CDD:214559 5/54 (9%)
TSP1 1160..>1183 CDD:214559 1/22 (5%)
TSP1 1209..1265 CDD:214559 9/55 (16%)
TSP1 1363..1417 CDD:214559 11/53 (21%)
TSP_1 1483..1526 CDD:301595 16/43 (37%)
GON 1715..1910 CDD:285848 73/198 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 120 1.000 Domainoid score I5764
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 609 1.000 Inparanoid score I926
Isobase 1 0.950 - 0 Normalized mean entropy S5882
OMA 1 1.010 - - QHG48392
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 1 1.000 - - FOG0004456
OrthoInspector 1 1.000 - - otm42007
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3160
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.830

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