DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and THSD4

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_001381461.1 Gene:THSD4 / 79875 HGNCID:25835 Length:1018 Species:Homo sapiens


Alignment Length:1051 Identity:241/1051 - (22%)
Similarity:365/1051 - (34%) Gaps:311/1051 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   633 WS-WSKCSRHFVSEFLEKTDKSCLETSV---GAHIPYGTERLPGE--IYSLDAQCQLSFGNDFGY 691
            |. ||.|||......:|:| :.||..|.   |...|....|...:  :.::.....|....|   
Human    59 WGPWSACSRSCSGGVMEQT-RPCLPRSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRD--- 119

  Fly   692 CPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGP 756
                 |...|.....|.........|..|...|...........||.....|:|||:      .|
Human   120 -----ETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGK------AP 173

  Fly   757 W-------TPFTPCSL---------TCGGGVQESRRECNQP---VPENGGKY------------- 789
            :       |..||..|         :...|...:|...:.|   ||::|..|             
Human   174 YILPLQTDTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAA 238

  Fly   790 ----------------------------------------------------CTGSRKKYRSCNT 802
                                                                |.|:.::|:.|||
Human   239 EAPIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAYRQYKLCNT 303

  Fly   803 HQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE---KDACKLFCRMDMKVTYFMLKSMV 864
            :.||..|...||.||.:.|    |.|.:....:|.|..|   ...|:|.|:......|......|
Human   304 NVCPESSRSIREVQCASYN----NKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKV 364

  Fly   865 TDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTG---NLLVSNLLGL 926
            .|||.|..:....||:|.|:..|||:.|.|...:||||||.|.|..|..|:|   :.|.|  || 
Human   365 IDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTS--LG- 426

  Fly   927 NDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVT 991
                     .:.|..||:||:.|.||:. |...|::.|.......::||.:....|.|:...|..
Human   427 ---------YHRVVEIPEGATKINITEM-YKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTM 481

  Fly   992 MQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI--------DKPP-- 1046
            ..|...:.:......::   |:.....:|  |||....:|....:.|.|.|        ..||  
Human   482 FTYKRPNEISSTAGESF---LAEGPTNEI--LDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHR 541

  Fly  1047 ------------------------------DYEAEV-EIY------------------------- 1055
                                          |...|. |::                         
Human   542 RPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLV 606

  Fly  1056 -------------RWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRAC 1106
                         .|:....:.|.:.| :|..:.:..|:..:...:....:||.|..|..::..|
Human   607 PPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPC 671

  Fly  1107 NT-DCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVD------------MSYCKL 1158
            |. .|.....:...||||..|| ||.:.:...|.|.:.|  ||..|.            .|.|:|
Human   672 NIFPCPAFWDIGEWSECSKTCG-LGMQHRQVLCRQVYAN--RSLTVQPYRCQHLEKPETTSTCQL 733

  Fly  1159 KFDVAYHEECREGCW-VLSEWSTCSKSCGTGSQQREAHCYLH-NSRVSDDLCNPRTKPHLNTLIG 1221
            |.       |.|  | :.::|::||..||.|.:.|:..|..: ...|.|:.||.:.:|:      
Human   734 KI-------CSE--WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPN------ 783

  Fly  1222 ICNTESCPTYTKSPNALAVSNWVIGEWGE-CNEWC---EKTRSVSC--SHPYGI---GCGSRKPK 1277
              :.|:|   ...|.|   .:|.:.||.| |:..|   .:||||.|  :|...:   |||:.:|.
Human   784 --DIENC---DMGPCA---KSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA 840

  Fly  1278 DVRKC----CHIK---YTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVY--VDESYCI 1333
            :...|    |..|   :...|:.||::||.|.::::..|.|         :....:  :|.|.| 
Human   841 EATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVR---------KNADTFEVLDPSEC- 895

  Fly  1334 SRKVHRPKLRTTTKSCRI---NCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKK 1395
             ..:.:|   .:.:||.:   ..||.:::|..|...|...::.|:|||.|  .|......||.:.
Human   896 -SFLEKP---PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLS--DDMTLSNLCDPQL 954

  Fly  1396 RPSKRRICN--NCVRRQSRVISQC-----NCEGVEKRRDFCFNSHKGRIACPTRARVERHSCTPP 1453
            :|.:|..||  :||   ..|...|     ||..|.:.|...:|.:|  .||..       |||..
Human   955 KPEERESCNPQDCV---PEVDENCKDKYYNCNVVVQARLCVYNYYK--TACCA-------SCTRV 1007

  Fly  1454 PHCRRRSAIGS 1464
            .: |:...:||
Human  1008 AN-RQTGFLGS 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848
ZnMc_ADAMTS_like 455..655 CDD:239801 8/22 (36%)
Reprolysin 457..655 CDD:279729 8/22 (36%)
Salp15 <696..745 CDD:288931 9/48 (19%)
TSP1 754..806 CDD:214559 18/135 (13%)
ADAM_spacer1 937..1042 CDD:283607 25/104 (24%)
TSP1 1172..1229 CDD:214559 15/58 (26%)
GON 1495..1687 CDD:285848
THSD4NP_001381461.1 TSP1 58..>95 CDD:214559 13/36 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..235 26/137 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..279 0/24 (0%)
ADAM_spacer1 412..528 CDD:368694 31/133 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..623 6/88 (7%)
TSP1_ADAMTS 627..676 CDD:408800 10/48 (21%)
TSP1_ADAMTS 680..736 CDD:408800 18/65 (28%)
TSP1_ADAMTS 739..793 CDD:408800 16/64 (25%)
TSP1_ADAMTS 797..850 CDD:408800 17/52 (33%)
TSP1_ADAMTS 856..912 CDD:408800 14/69 (20%)
TSP1_ADAMTS 916..967 CDD:408800 16/52 (31%)
PLAC 975..1005 CDD:400844 10/38 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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