DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and THSD4

DIOPT Version :10

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_079093.2 Gene:THSD4 / 79875 HGNCID:25835 Length:1018 Species:Homo sapiens


Alignment Length:1051 Identity:241/1051 - (22%)
Similarity:365/1051 - (34%) Gaps:311/1051 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   633 WS-WSKCSRHFVSEFLEKTDKSCLETSV---GAHIPYGTERLPGE--IYSLDAQCQLSFGNDFGY 691
            |. ||.|||......:|:| :.||..|.   |...|....|...:  :.::.....|....|   
Human    59 WGPWSACSRSCSGGVMEQT-RPCLPRSYRLRGGQRPGAPARAFADHVVSAVRTSVPLHRSRD--- 119

  Fly   692 CPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGP 756
                 |...|.....|.........|..|...|...........||.....|:|||:      .|
Human   120 -----ETPALAGTDASRQGPTVLRGSRHPQPQGLEVTGDRRSRTRGTIGPGKYGYGK------AP 173

  Fly   757 W-------TPFTPCSL---------TCGGGVQESRRECNQP---VPENGGKY------------- 789
            :       |..||..|         :...|...:|...:.|   ||::|..|             
Human   174 YILPLQTDTAHTPQRLRRQKLSSRHSRSQGASSARHGYSSPAHQVPQHGPLYQSDSGPRSGLQAA 238

  Fly   790 ----------------------------------------------------CTGSRKKYRSCNT 802
                                                                |.|:.::|:.|||
Human   239 EAPIYQLPLTHDQGYPAASSLFHSPETSNNHGVGTHGATQSFSQPARSTAISCIGAYRQYKLCNT 303

  Fly   803 HQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE---KDACKLFCRMDMKVTYFMLKSMV 864
            :.||..|...||.||.:.|    |.|.:....:|.|..|   ...|:|.|:......|......|
Human   304 NVCPESSRSIREVQCASYN----NKPFMGRFYEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKV 364

  Fly   865 TDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTG---NLLVSNLLGL 926
            .|||.|..:....||:|.|:..|||:.|.|...:||||||.|.|..|..|:|   :.|.|  || 
Human   365 IDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTS--LG- 426

  Fly   927 NDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVT 991
                     .:.|..||:||:.|.||:. |...|::.|.......::||.:....|.|:...|..
Human   427 ---------YHRVVEIPEGATKINITEM-YKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTM 481

  Fly   992 MQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI--------DKPP-- 1046
            ..|...:.:......::   |:.....:|  |||....:|....:.|.|.|        ..||  
Human   482 FTYKRPNEISSTAGESF---LAEGPTNEI--LDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHR 541

  Fly  1047 ------------------------------DYEAEV-EIY------------------------- 1055
                                          |...|. |::                         
Human   542 RPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLV 606

  Fly  1056 -------------RWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRAC 1106
                         .|:....:.|.:.| :|..:.:..|:..:...:....:||.|..|..::..|
Human   607 PPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPC 671

  Fly  1107 NT-DCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVD------------MSYCKL 1158
            |. .|.....:...||||..|| ||.:.:...|.|.:.|  ||..|.            .|.|:|
Human   672 NIFPCPAFWDIGEWSECSKTCG-LGMQHRQVLCRQVYAN--RSLTVQPYRCQHLEKPETTSTCQL 733

  Fly  1159 KFDVAYHEECREGCW-VLSEWSTCSKSCGTGSQQREAHCYLH-NSRVSDDLCNPRTKPHLNTLIG 1221
            |.       |.|  | :.::|::||..||.|.:.|:..|..: ...|.|:.||.:.:|:      
Human   734 KI-------CSE--WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPN------ 783

  Fly  1222 ICNTESCPTYTKSPNALAVSNWVIGEWGE-CNEWC---EKTRSVSC--SHPYGI---GCGSRKPK 1277
              :.|:|   ...|.|   .:|.:.||.| |:..|   .:||||.|  :|...:   |||:.:|.
Human   784 --DIENC---DMGPCA---KSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPA 840

  Fly  1278 DVRKC----CHIK---YTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVY--VDESYCI 1333
            :...|    |..|   :...|:.||::||.|.::::..|.|         :....:  :|.|.| 
Human   841 EATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVR---------KNADTFEVLDPSEC- 895

  Fly  1334 SRKVHRPKLRTTTKSCRI---NCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKK 1395
             ..:.:|   .:.:||.:   ..||.:::|..|...|...::.|:|||.|  .|......||.:.
Human   896 -SFLEKP---PSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLS--DDMTLSNLCDPQL 954

  Fly  1396 RPSKRRICN--NCVRRQSRVISQC-----NCEGVEKRRDFCFNSHKGRIACPTRARVERHSCTPP 1453
            :|.:|..||  :||   ..|...|     ||..|.:.|...:|.:|  .||..       |||..
Human   955 KPEERESCNPQDCV---PEVDENCKDKYYNCNVVVQARLCVYNYYK--TACCA-------SCTRV 1007

  Fly  1454 PHCRRRSAIGS 1464
            .: |:...:||
Human  1008 AN-RQTGFLGS 1017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep <295..394 CDD:460254
ZnMc_ADAMTS_like 455..655 CDD:239801 8/22 (36%)
ADAMTS_CR_2 671..740 CDD:465496 10/70 (14%)
TSP1 754..806 CDD:214559 18/135 (13%)
ADAMTS_CR_3 815..911 CDD:437068 34/98 (35%)
TSP1 1172..1229 CDD:214559 15/58 (26%)
TSP1_ADAMTS 1243..1282 CDD:465950 16/47 (34%)
TSP1_ADAMTS 1355..1405 CDD:465950 16/51 (31%)
GON 1493..1687 CDD:462559
THSD4NP_079093.2 TSP1 58..>95 CDD:214559 13/36 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..235 26/137 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..279 0/24 (0%)
ADAMTS_CR_3 317..411 CDD:437068 34/97 (35%)
ADAMTS_spacer1 413..528 CDD:461796 31/132 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..623 6/88 (7%)
TSP1_ADAMTS 627..676 CDD:465950 10/48 (21%)
TSP1_ADAMTS 680..736 CDD:465950 18/65 (28%)
TSP1_ADAMTS 739..793 CDD:465950 16/64 (25%)
TSP1_ADAMTS 797..850 CDD:465950 17/52 (33%)
TSP1_ADAMTS 856..912 CDD:465950 14/69 (20%)
TSP1_ADAMTS 916..967 CDD:465950 16/52 (31%)
PLAC 975..1005 CDD:462560 10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

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