DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and Adamtsl2

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_084257.1	Gene:	Adamtsl2 / 77794	MGIID:	1925044	Length:	957	Species:	Mus musculus

Alignment Length:	1028	Identity:	224/1028 - (21%)
Similarity:	327/1028 - (31%)	Gaps:	390/1028 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 ASSNLPWADGTPCG--SSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRE 777
            ||.|.|.::....|  ::.:|                    ||.||.:|.||.:|||||....|.
Mouse    29 ASDNSPTSNSLEGGADTTAYW--------------------WGEWTKWTACSRSCGGGVTSQERH 73

  Fly   778 CNQ----PVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVP 838
            |.|    .||..|.:.|.|:.|:|:.|...:|||.....||:||.:.|.|..:    ....:|.|
Mouse    74 CLQQRRKSVPGTGNRTCVGTSKRYQLCRVQECPPDGRSFREEQCVSFNSRVYD----GRAYQWKP 134

  Fly   839 KYEKD-------ACKLFC-RMDMKVTYFMLKSMVTDGTSCAV-DSFDKCVNGICRPAGCDNELNS 894
            .|..|       .|.|.| .:|.:   ..|.....|||||.: |....||:|.|.|.|||..|.|
Mouse   135 LYPDDYVHISSKPCDLHCSTVDGQ---RQLTVPARDGTSCKLTDLRGVCVSGKCEPIGCDGVLFS 196

  Fly   895 IAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY--VTRIPKGASNIIITQRGYP 957
            ...|||||||:|...:|..||||.           .:.|..|.|  ||.||.||.:|.|.:| ..
Mouse   197 THTLDKCGVCQGDGSSCTHVTGNY-----------RKGNNHLGYSLVTHIPAGARDIQIVER-KK 249

  Fly   958 DQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQY--------TGSSSVVEQVNT-------- 1006
            ..:.:.|.|:......||.:....|..|..||..::|        ||...:|.|..|
Mouse   250 SADVLALADEAGFYFFNGNYKVDSPKNFNIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMV 314

  Fly  1007 ----------TYSWKLSRD---------------------------------------------- 1015
                      |:.:.|.:.
Mouse   315 WNQNGKSPSITFEYTLLQSPHMHHLPPVYYSFSEAASQSTESTERQELDSARLLGFMQHNGSLYR 379

  Fly  1016 --------LIVQII-----SLDVSPSKRQDT---------------------------------- 1033
                    |..|:.     .:::.||:.|::
Mouse   380 QTSSERLGLNSQLFQPPAPEVELGPSRGQESNEVCKQASGGVCEGPPRGKGFQDHNATGRAFSAD 444

  Fly  1034 ----------------------------------------------------------------- 1033

Mouse   445 KDDREISAHFTSHELLSANTISDQLLGTGSESEEFSLNETMNSIFAQGAPRSSPAESLYVDYEEN 509

  Fly  1034 -----VLLSYSY------------------TIDKPPDYE------------------AEVEIYRW 1057
                 .|::.||                  |...||:..                  :..::|||
Mouse   510 EGPAAYLINGSYLELSSDRINTSSEAPFPNTSASPPNLAGNRTHKARTRPKARKQGVSPADMYRW 574

  Fly  1058 EMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAMPK-IDDRACNTDCRLNLTVTSIS 1120
            ::.:...|.:.| .|.......|: ...||:|...:||....|: :.:.....:|:.....:|.|
Mouse   575 KLSSHEPCSATCTTGVMSTYAMCV-RYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWS 638

  Fly  1121 ECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEE--CRE-GC---WVLSEWS 1179
            |||..||| |.:.:...|.:..:....|::.. ..|:....|...|.  ||. .|   |.:||||
Mouse   639 ECSRTCGE-GHQFRIVRCWKMLSPGFDSSVYS-DLCEATEAVRPEERKTCRNPACGPQWEMSEWS 701

  Fly  1180 TCSKSCGTGSQQREAHCYLHNSRVSDD--LCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSN 1242
            .|:..||      |......:.|.|:|  ||:|.|||     :|..|....|         ....
Mouse   702 ECTAKCG------ERSVVTRDIRCSEDEKLCDPSTKP-----VGEKNCTGPP---------CDRQ 746

  Fly  1243 WVIGEWGECNEWCEKTRSVSCSHPYGIGCGSR-----------KPKDVRKC----CHIKY-TSDW 1291
            |.:.:||.|:..|.:.|::  .|.|......|           ||..:..|    |...: ..||
Mouse   747 WTVSDWGPCSGSCGQGRTI--RHVYCKTSDGRVVPESQCQTETKPLAIHPCGDKNCPAHWLAQDW 809

  Fly  1292 TDCSVQCGEGVKRKKQSCTRVY--KPDV---PGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRI 1351
            ..|:..||.|||::...|..:.  ||.:   |.....|...:||.|..|.
Mouse   810 ERCNTTCGRGVKKRLVLCMELANGKPQIRSGPECGLARKPPEESTCFERP--------------- 859

  Fly  1352 NC-KWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVIS 1415
             | ||..|.|..|...|....:.|||:|  :||..:. :.||...:|..|:.|:         :.
Mouse   860 -CFKWYTSPWSECTKTCGVGVRMRDVKC--YQGTDIV-RGCDPLVKPVGRQACD---------LQ 911

  Fly  1416 QC---------------NCEGVEKRRDFCFNSHKGRIACPTRARVERHSCTPP 1453
            .|               || .:..:.:.|.:.:..:..|        .||.||
Mouse   912 PCPTEPPDDSCQDQPGTNC-ALAIKVNLCGHWYYSKACC--------RSCRPP 955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931	6/31 (19%)
		TSP1	754..806	CDD:214559	23/55 (42%)
		ADAM_spacer1	937..1042	CDD:283607	34/313 (11%)
		TSP1	1172..1229	CDD:214559	21/61 (34%)
		GON	1495..1687	CDD:285848
Adamtsl2	NP_084257.1	TSP1	50..106	CDD:214559	23/55 (42%)
		ADAM_spacer1	216..330	CDD:368694	31/125 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..568		3/35 (9%)
		TSP1_ADAMTS	632..691	CDD:408800	16/60 (27%)
		TSP1_ADAMTS	695..743	CDD:408800	21/67 (31%)
		TSP1_ADAMTS	747..800	CDD:408800	12/54 (22%)
		TSP1_ADAMTS	804..860	CDD:408800	17/71 (24%)
		TSP1_ADAMTS	863..913	CDD:408800	16/61 (26%)
		PLAC	922..953	CDD:400844	5/39 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900