DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and Adamtsl5

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_011241828.1	Gene:	Adamtsl5 / 66548	MGIID:	1913798	Length:	548	Species:	Mus musculus

Alignment Length:	359	Identity:	102/359 - (28%)
Similarity:	155/359 - (43%)	Gaps:	65/359 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 GGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQ 816
            |.|.||..::.||.:||.||...||:|   |...|.:.|.|...:||.|....||||:...|:.|
Mouse   110 GEWTPWGSWSRCSSSCGRGVSVRRRQC---VRLPGEELCWGDSHEYRVCQLPDCPPGTTPFRDLQ 171

  Fly   817 CYAMNGRNMNIPGVNP--DT----KWVPKY-EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDS 874
            |...||        :|  ||    :|||.: ..:.|.|.|..:....|... ..|.|||.|...:
Mouse   172 CSLYNG--------HPVLDTQKTYQWVPFHGAPNVCDLNCLAEGHAFYHSF-GRVLDGTPCTPGT 227

  Fly   875 FDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLL---GLNDGNEPNKTL 936
            ...||.|.|..||||..|.|....|:||:|.|.||:|      |.|..:.   |...|      .
Mouse   228 QGLCVAGRCLSAGCDGILGSGTLEDRCGLCGGANDSC------LFVQRVFRDAGAFAG------F 280

  Fly   937 YYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVV 1001
            :.||.||:||.:|.:.||.:   |.:.|.....:.:|||..:.:.|..:..||..:.||.|:...
Mouse   281 WNVTLIPEGARHIRVAQRSH---NHLALVTRGGHYVLNGDGVLSPPGTYEAAGTRVVYTRSAGPE 342

  Fly  1002 EQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCD 1066
            |.:..|  ...|::|::|::..:.:|.     |...:....::...::|:|:...|.::.|
Mouse   343 ETLQAT--GPTSQELLLQVLLREPNPG-----VHFEFWLPRERYGPFQAQVQALGWPLRQP---- 396

  Fly  1067 SLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPK 1100
                             |..:|.||..:...:|:
Mouse   397 -----------------QPREVEPQPAETPVVPE 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	19/51 (37%)
		ADAM_spacer1	937..1042	CDD:283607	27/104 (26%)
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
Adamtsl5	XP_011241828.1	TSP1	112..161	CDD:214559	19/51 (37%)
		ADAM_spacer1	270..375	CDD:368694	29/120 (24%)
		NTR_like	442..541	CDD:239600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900