DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and Adamts4

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_076449.1	Gene:	Adamts4 / 66015	RGDID:	621242	Length:	851	Species:	Rattus norvegicus

Alignment Length:	914	Identity:	282/914 - (30%)
Similarity:	418/914 - (45%)	Gaps:	159/914 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 STHPLANSPPATPATLHPRRLDNDTSTDHE--------PP-----DGLDDLDEEEHSAFVMPTKV 245
            |.||..::...:...|||||    ..|.|.        ||     .||:...:....|.::|..
  Rat     3 SIHPSCSTGTMSRMGLHPRR----GLTGHRLRRLQPCLPPRTVPFSGLERWQQLLLLASLLPLA- 62

  Fly   246 YNYSLS----EADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNVFGRQLH 306
              :|.|    |.::::..|.|         .:|....:|....:         .|.|..||..|.
  Rat    63 --WSASPLPREEEIVFPEKLN---------GSSIIPGSGVPARL---------LYRLPAFGEILL 107

  Fly   307 LVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVSVSL-CGG 370
            |.|.||.. |....:| ::.|.:     .||....||.   |.:.:|.:..||.|:.|:.. .|.
  Rat   108 LELEQDPG-VQVEGLT-VQYLGQ-----APEMLGGAEP---GTYLTGTINGDPESVASLHWDRGA 162

  Fly   371 MTGYIKTSFGALLIQPVN----RTSSDEVLHRVFRKSQRNARHAVSKFELGLDDFMSKLEQVQEE 431
            :.|.::.....|.:||:.    .::.....|.:.|||..:.|..:...                :
  Rat   163 LLGVLQYRGAELHLQPLEGGALNSAGGPGAHILRRKSPASNRGPICNV----------------K 211

  Fly   432 EQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIG 496
            ........::|:.:.:|.:...|   |.|:..|:.|..|||..|:.|:|.:|:..:..|...||.
  Rat   212 APSGSPSPISRRNKRFASLSRFV---ETLVVADDKMAAFHGAGLKHYLLTVMAAAAKAFKHPSIR 273

  Fly   497 NSIRILLVRLISL------PNINDQTHSSNEMLKHFCQFINQSGYER---------DTAMLITRE 546
            |.:.:::.||:.|      |.:..   |:.:.|:.||.:  |.|...         |||:|.||:
  Rat   274 NPVNLVVTRLVILGSGQEVPQVGP---SAAQTLRSFCTW--QKGLNPPNDSDPDHFDTAILFTRQ 333

  Fly   547 PICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYV 610
            .:||.   ..|..||:|.:||||. :.||:||:|.||.:|||.||||||:.||.||:...|....
  Rat   334 DLCGV---STCDALGMAGVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCANLN 395

  Fly   611 TRQNNNKVLHIMSSVMGIHMHPWS-WSKCSRHFVSEFLEKTDKSCL--ETSVGAHIPYGTERLPG 672
            .:.::::  |:|:.||. |:.|.. ||.||..|:::||:.....||  :.....|:|.   ..||
  Rat   396 GQGSSSR--HVMAPVMA-HVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPV---TFPG 454

  Fly   673 EIYSLDAQCQLSFGNDFGYCP-TDEECKRLWCNRTSG--NSNEQCASSNLPWADGTPCGSSGHWC 734
            :.|..|.||||:||.|..:|| ....|..|||   .|  |.:..|.:.:.|||||||||.: ..|
  Rat   455 KDYDADRQCQLTFGPDSSHCPQLPPPCAALWC---FGHLNGHAMCQTKHSPWADGTPCGPA-QAC 515

  Fly   735 QRGKC--VSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKY 797
            ..|:|  |.....:.....||||||.|:..||.|||||||.|.|:|.:|||.||||||.|.|..:
  Rat   516 MGGRCLHVDQLKDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTKPVPRNGGKYCEGRRTPF 580

  Fly   798 RSCNTHQCPPGS-MDPREQQCYAMNGRN---MNIPGVNPDTKWVPKY----EKDACKLFCRMDMK 854
            |||||..||.|| :..||:||.|.|.|.   .:.||   ...|||:|    .:|.|||.|:....
  Rat   581 RSCNTKNCPHGSALTFREEQCAAYNHRTDLFKSFPG---PMDWVPRYTGVAPRDQCKLTCQARAL 642

  Fly   855 VTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL 919
            ..|::|:..|.|||.|:.||...||.|.|..||||..:.|..|.|||.||.|...:|.:.:|:.
  Rat   643 GYYYVLEPRVADGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGNGSSCSKQSGSF- 706

  Fly   920 VSNLLGLNDGNEPNKTLYY----VTRIPKGASNIIITQRGYPDQN--FIVLTDDRDNELLNGKF- 977
                          |...|    |..||.|.::|::.|:|.....  ::.|.....:..|||::
  Rat   707 --------------KKFRYGYSDVVTIPAGRTHILVRQQGGSGLKSIYLALKLADGSYALNGEYT 757

  Fly   978 LKTYPLKFVYAG-VTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYT 1041
            |.......|..| |:::|:|.::..|.::       ....:.|.::|.|..:.....|.|.||:.
  Rat   758 LMPSSTDVVLPGAVSLRYSGRTAASETLS-------GHGPLAQPLTLQVLVAGNPQNVRLRYSFF 815

  Fly  1042 IDKP 1045
            :.:|
  Rat   816 VPRP 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	27/112 (24%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/216 (35%)
		Reprolysin	457..655	CDD:279729	75/214 (35%)
		Salp15	<696..745	CDD:288931	20/52 (38%)
		TSP1	754..806	CDD:214559	33/51 (65%)
		ADAM_spacer1	937..1042	CDD:283607	26/112 (23%)
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
Adamts4	NP_076449.1	Pep_M12B_propep	92..195	CDD:279848	28/121 (23%)
		Reprolysin	232..442	CDD:279729	78/223 (35%)
		ZnMc_ADAMTS_like	232..439	CDD:239801	77/220 (35%)
		ADAM_CR	452..523	CDD:301627	32/74 (43%)
		TSP1	545..589	CDD:214559	28/43 (65%)
		ADAM_spacer1	701..816	CDD:283607	28/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8136
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820