DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and ADGRB1

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_016869180.1	Gene:	ADGRB1 / 575	HGNCID:	943	Length:	1663	Species:	Homo sapiens

Alignment Length:	1216	Identity:	218/1216 - (17%)
Similarity:	320/1216 - (26%)	Gaps:	570/1216 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   541 MLITREPICGSVPGKI------------CHMLGLA---ELGTVCSSSSCSIVQDTGLPTAFTMAH 590
            |.:.:.|:..|.||::            ...||:.   |:..:|         |...|.||..|.
Human    84 MKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLC---------DPSAPLAFLQAS 139

  Fly   591 ELGHILNM------NHD-----------DDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKC 638
            :  ..|.|      .||           .||..:.|:...|.|.                  |:.
Human   140 K--QFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRNP------------------SRA 184

  Fly   639 SRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFG------YCPTDEE 697
            :...:..:|:    :||..|..:| |.|..:.|       ..|   .|.:.|      ..|..:.
Human   185 ACQMLCRWLD----ACLAGSRSSH-PCGIMQTP-------CAC---LGGEAGGPAAGPLAPRGDV 234

  Fly   698 CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTP 762
            |.|   :..:|.. |.|.:|                     ...::.|:|  ..|||..|:.:..
Human   235 CLR---DAVAGGP-ENCLTS---------------------LTQDRGGHG--ATGGWKLWSLWGE 272

  Fly   763 CSLTCGGGVQESRRECNQPVP--ENGGKYCTGSRKKYRSCNTHQC-PPGSMDPREQQCYAMNGRN 824
            |:..||||:|...|.| .|.|  |.||  |.|..::.|.||...| |.|....|.|...:.:.|.
Human   273 CTRDCGGGLQTRTRTC-LPAPGVEGGG--CEGVLEEGRQCNREACGPAGRTSSRSQSLRSTDARR 334

  Fly   825 MNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCD 889
            .
Human   335 R---------------------------------------------------------------- 335

  Fly   890 NELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQR 954
            .||                                    |:|                   :.|.
Human   336 EEL------------------------------------GDE-------------------LQQF 345

  Fly   955 GYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQ 1019
            |:|                                  ...||..:..|       |
Human   346 GFP----------------------------------APQTGDPAAEE-------W--------- 360

  Fly  1020 IISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLC-EGRSHRLPACISTT 1083
                  ||                             |     |.|.|.| ||...|...|:|::
Human   361 ------SP-----------------------------W-----SVCSSTCGEGWQTRTRFCVSSS 385

  Fly  1084 QGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRS 1148
                    :..:.:.|..:.|.||.              ||.|...|
Human   386 --------YSTQCSGPLREQRLCNN--------------SAVCPVHG------------------ 410

  Fly  1149 NIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTK 1213
                          |:.|      |  |.||.||.:||.|.:.|...|     |......||...
Human   411 --------------AWDE------W--SPWSLCSSTCGRGFRDRTRTC-----RPPQFGGNPCEG 448

  Fly  1214 PHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRKPKD 1278
            |...|  ..||...||           ...|.|.|   |||
Human   449 PEKQT--KFCNIALCP-----------GRAVDGNW---NEW------------------------ 473

  Fly  1279 VRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLR 1343
                      |.|:.||..|.:|.:::.:.|.   .|...|...:..:|:...|.
Human   474 ----------SSWSACSASCSQGRQQRTRECN---GPSYGGAECQGHWVETRDCF---------- 515

  Fly  1344 TTTKSCRINCKWNA-SDWRRCPADCSEEYQTRDVRCE-------SFQGDGVEDKHCDAKKRPSKR 1400
              .:.|.::.||.| :.|..|...|....|.|:..|.       :.||...|.:.|..::.|...
Human   516 --LQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPH 578

  Fly  1401 RICN--------------------NCVRRQSRVISQCNCEGVEKRRDFCFNSHKGRIACPTRARV 1445
            .||:                    .|.|         |..|:..||  |....:| ||
Human   579 EICDEDNFGAVIWKETPAGEVAAVRCPR---------NATGLILRR--CELDEEG-IA------- 624

  Fly  1446 ERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSRSLNSIGGSRNRGTPRSCADLKEMH----GYN 1506
               ...||.:.|..|....:|....|.....:.|.|...|.|....|      |.|:.    .|:
Human   625 ---YWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQT------LVEISQDGTSYS 680

  Fly  1507 KDGNYQLEVRSRMVHIYCHGMNSRTP---QEYV----NVDPQENYSIYYEYRTKQTNSCPPESRG 1564
            .|....::|...|..|:.....|.||   |.:|    |:..:||...:.|.:....|:
Human   681 GDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILSNLLAEENRDKWEEAQLAGPNA------- 738

  Fly  1565 HEYYNDQNSGRTHFRKLR--LNITDLRIMD--NDFKFADSRGLA-QKLGSAGDCYNRIGQCPQGD 1624
                      :..||.:.  :::...|:.|  :.::..|:..|: .||.::|          ..|
Human   739 ----------KELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASG----------ATD 783

  Fly  1625 FSINMKDTDFSIRPGTVWRMHGQYSVMKRISEFDTTTQMRRGFCGG 1670
            .|..||.          ||..|.::   ::.| |..|..:..|..|
Human   784 ISFPMKG----------WRATGDWA---KVPE-DRVTVSKSVFSTG 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801	25/145 (17%)
		Reprolysin	457..655	CDD:279729	25/145 (17%)
		Salp15	<696..745	CDD:288931	6/48 (13%)
		TSP1	754..806	CDD:214559	21/54 (39%)
		ADAM_spacer1	937..1042	CDD:283607	9/104 (9%)
		TSP1	1172..1229	CDD:214559	18/56 (32%)
		GON	1495..1687	CDD:285848	38/192 (20%)
ADGRB1	XP_016869180.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900