DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and ADAMTSL3

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_011520124.1 Gene:ADAMTSL3 / 57188 HGNCID:14633 Length:1718 Species:Homo sapiens


Alignment Length:1235 Identity:257/1235 - (20%)
Similarity:398/1235 - (32%) Gaps:461/1235 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   751 NGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQ 815
            :|.|..|..::.||.|||||...|.|.|..      |:.|.|...:|::|:.|.|||.:.|.|.|
Human    75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAEDFRAQ 133

  Fly   816 QCYAMNGRNMNIPGVNPDTKWVPKYEKDA--CKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKC 878
            ||.|.|    ::.......:|:|:|...|  |.|.|....:.....|...|.|||.|..||.|.|
Human   134 QCSAYN----DVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMC 194

  Fly   879 VNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTG----NLLVSNLLGLNDG---------- 929
            ::|||:..|||.:|.|.||.|.||||.|...||..|.|    ::......||..|          
Human   195 ISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKTPGLPPGQGGPLPGGHL 259

  Fly   930 ----------NEPNKTLYYVTRIPKGASNIIITQRGYPDQNFI-------------------VLT 965
                      .|.|     |..:|.|:.::.||.:| |...||                   .|.
Human   260 SAIYEWPILKGEEN-----VIAVPLGSRSVRITVKG-PAHLFIESKTLQGSKGEHSFNSPGVFLV 318

  Fly   966 DDRDNELLNGKFLKTY----PL--KFVYAGVTMQYTGSSSVVEQV----NTTYSWK--------- 1011
            ::...|...|...:|:    ||  .|::   ..:||.:...|.|.    ..::.|:         
Human   319 ENTTVEFQRGSERQTFKIPGPLMADFIF---KTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTV 380

  Fly  1012 -------LSRDLIVQI--------------------------ISLDVSPSKRQDTVLLSYSYTID 1043
                   |:....|.|                          .|:|..||......::.|.:...
Human   381 TCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQP 445

  Fly  1044 KPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLP-ACISTT---QGVKVAPQFCDKSAMPKIDDR 1104
            .|          |||....:.|...|.|...|.. .|:..:   :.::|....|..:..||: .:
Human   446 LP----------RWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKV-MQ 499

  Fly  1105 ACNT-DCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEEC 1168
            .||. ||...:.: ..|:|:..||. |.|.:...|:    |.:..::   ..|..:..:...|||
Human   500 TCNLFDCPKWIAM-EWSQCTVTCGR-GLRYRVVLCI----NHRGEHV---GGCNPQLKLHIKEEC 555

  Fly  1169 -----------------------------------REGCWVLSEWSTCSKSCGTGSQQREAHC-- 1196
                                               .|..::...||.||.:||.|.|.||..|  
Human   556 VIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRV 620

  Fly  1197 ----------------------------------------------------------------- 1196
                                                                             
Human   621 LLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTA 685

  Fly  1197 ------------YLH---NSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIG 1246
                        .||   ...|:|.||:...:|  ..:...||||.||           ..|.:|
Human   686 TCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRP--PAMSQACNTEPCP-----------PRWHVG 737

  Fly  1247 EWGECNEWCE---KTRSVSCSHPYGIG--------CGSRKPKDVRKC----C----HIKYTSDWT 1292
            .||.|:..|.   :||.|.|.||   |        |...||..::.|    |    ||:   :|.
Human   738 SWGPCSATCGVGIQTRDVYCLHP---GETPAPPEECRDEKPHALQACNQFDCPPGWHIE---EWQ 796

  Fly  1293 DCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYC-ISRKVHRPKLRTTTKSC-RINCKW 1355
            .||..||.|.:.::.:|             |::..|.|:. :|.::.:....::.||| |.:|..
Human   797 QCSRTCGGGTQNRRVTC-------------RQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPP 848

  Fly  1356 N--ASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNN------------- 1405
            :  ..||.:|...|....|.|...|:.....|        ::.|....:|.:             
Human   849 HLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKG--------RRIPLSEMMCRDLPGLPLVRSCQMP 905

  Fly  1406 -CVRRQSRVISQCNCEG--------------VEKR-------RDFCFNSHKGRIACPTRARVERH 1448
             |.:.:|.:.::...:|              .|||       |.:...:....|.||.|.     
Human   906 ECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRR----- 965

  Fly  1449 SCTPPPHCRRRSAI-----GSSISSRPRGTGVSSSRSLNSIG-GSRNRGTPRSCADLKEMHGYNK 1507
                    .::|.|     |..:.:..| .|::.|.||...| .:.:.|..|..|          
Human   966 --------FQKSLIQWEKDGRCLQNSKR-LGITKSGSLKIHGLAAPDIGVYRCIA---------- 1011

  Fly  1508 DGNYQLEVRSRMVHIYCHGMNSR---------TPQEYVNVDPQENYSI---YYEYRTKQTNSCPP 1560
             |:.|..|..:::     |.::|         ..:||..:|..|..|:   :::.|         
Human  1012 -GSAQETVVLKLI-----GTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMR--------- 1061

  Fly  1561 ESRGHEYYNDQNSGRTHFRKLRLNITDLRIMDNDFKFADSRGLAQKLGSAGDCYNRIGQ------ 1619
                 :.:|::|.         |.:.|..|.:..|    .|.|      .|.|.|..|.      
Human  1062 -----QMWNNKND---------LYLDDDHISNQPF----LRAL------LGHCSNSAGSTNSWEL 1102

  Fly  1620 --------CPQGDFSINMKDTDFSIRPGTVWRMHGQ----------YSVMKRISEFDTTTQMRRG 1666
                    ..||.:|::....|..||..:.....|:          |.::..:::...|....||
Human  1103 KNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRG 1167

  Fly  1667  1666
            Human  1168  1167

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848
ZnMc_ADAMTS_like 455..655 CDD:239801
Reprolysin 457..655 CDD:279729
Salp15 <696..745 CDD:288931
TSP1 754..806 CDD:214559 18/51 (35%)
ADAM_spacer1 937..1042 CDD:283607 29/175 (17%)
TSP1 1172..1229 CDD:214559 22/138 (16%)
GON 1495..1687 CDD:285848 35/208 (17%)
ADAMTSL3XP_011520124.1 TSP1 78..124 CDD:214559 18/51 (35%)
TSP1 453..>473 CDD:214559 4/19 (21%)
TSP1 513..>542 CDD:214559 8/36 (22%)
TSP1 598..>618 CDD:214559 10/19 (53%)
TSP1 734..787 CDD:214559 17/55 (31%)
TSP1 790..847 CDD:214559 17/72 (24%)
TSP1 853..908 CDD:214559 10/62 (16%)
Ig 956..1020 CDD:299845 19/88 (22%)
Ig 1238..1302 CDD:143165
IG_like 1336..1410 CDD:214653
IGc2 1341..1401 CDD:197706
TSP_1 1516..1571 CDD:301595
PLAC 1686..1716 CDD:285849
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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