DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and wfikkn2b

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_699239.1	Gene:	wfikkn2b / 570642	ZFINID:	ZDB-GENE-110414-1	Length:	563	Species:	Danio rerio

Alignment Length:	191	Identity:	41/191 - (21%)
Similarity:	59/191 - (30%)	Gaps:	72/191 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1173 WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNA 1237
            || ...|||.:.|.|                 |..|.|..|...|    :|.:.||
Zfish    52 WV-DAMSTCKRECQT-----------------DQECEPLEKCCAN----VCGSRSC--------- 85

  Fly  1238 LAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGV 1302
              |:...|...|:             ..|.|:      ||:. .|.....|...::|.::.|:.|
Zfish    86 --VAARYIDTTGK-------------KGPMGM------PKEA-SCDQFMCTQQGSECDIRDGQPV 128

  Fly  1303 KRKKQSCTRVYKPDVP-----GTRKRRVYVDESYC---ISRKVHRPKLRTTTKSCRINCKW 1355
            .:.:..|.|  :|...     .|...:.|:|...|   ||..|         .|||.:..|
Zfish   129 CKCRDRCER--EPQFTCASDGMTYYNKCYMDAEACSKGISLSV---------VSCRFHLSW 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559
		ADAM_spacer1	937..1042	CDD:283607
		TSP1	1172..1229	CDD:214559	14/55 (25%)
		GON	1495..1687	CDD:285848
wfikkn2b	XP_699239.1	WAP	41..87	CDD:278522	15/67 (22%)
		KAZAL_FS	135..171	CDD:238052	10/46 (22%)
		I-set	207..298	CDD:254352
		Ig	221..298	CDD:299845
		Kunitz_BPTI	317..367	CDD:278443
		Kunitz_BPTI	375..425	CDD:278443
		NTR_like	443..551	CDD:295338
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900