DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AdamTS-A and ADAMTS9

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_891550.1 Gene:ADAMTS9 / 56999 HGNCID:13202 Length:1935 Species:Homo sapiens


Alignment Length:2031 Identity:555/2031 - (27%)
Similarity:805/2031 - (39%) Gaps:664/2031 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 SPPATPAT----LHPRRLD-NDTSTDHE--PPDGLDDLDEEEHSAFVMPTKVYNYSLSEADLIYE 258
            ||.|..|.    ||||::. .:|.:::|  .|..::.|.|.      .||.|:          ::
Human    22 SPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALGEP------FPTNVH----------FK 70

  Fly   259 SKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTH 323
            ..|.| ||| ..:...|||.:.:....|      ...|.|:.||:|....|..:|.|:  ..:..
Human    71 RTRRS-INS-ATDPWPAFASSSSSSTSS------QAHYRLSAFGQQFLFNLTANAGFI--APLFT 125

  Fly   324 IRILKEGEEHPGPE-----TEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALL 383
            :.:|..    ||..     :|.|||.:|  |||.|||..:......:|||.||.|..::..|...
Human   126 VTLLGT----PGVNQTKFYSEEEAELKH--CFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYF 184

  Fly   384 IQPVNRTSSDE------VLHRVFRKS--QR---NARHAVSKFELGLDDFMSKLEQVQEEEQKSKS 437
            |:|:......|      ..|.::|:|  ||   ..|||.        |......:..::::|:::
Human   185 IEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHAC--------DTSEHKNRHSKDKKKTRA 241

  Fly   438 RKLNRKKRHYADV-------------------DNQ-------------VYT--LEVLIAVDNSMK 468
            ||...:.....||                   ||.             .|.  :|||:..||.|.
Human   242 RKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMV 306

  Fly   469 QFHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ---THSSNEMLKHFCQFI 530
            .:|||:||.|||.|||||:||:.|.||||.|.|::|.||.:.|..|.   :.::...||:|||:.
Human   307 SYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQ 371

  Fly   531 NQ----SGYERDTAMLITREPICGSVPGKICHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAH 590
            :.    .|...|||:|:||:.||.:  ...|..||||||||:|.. .||||.:|:||.||||:||
Human   372 HSKNSPGGIHHDTAVLLTRQDICRA--HDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAH 434

  Fly   591 ELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL 655
            ||||:.||.|||::||    ..:......|:|:..:..:.:||.||||||.:::|||:.....||
Human   435 ELGHVFNMPHDDNNKC----KEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECL 495

  Fly   656 ETSVGAHIPYGTE-RLPGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNL 719
            .....:. ||... :|||.:|:::.||:|.||.....||...:|:|||||..:| .::.|.:.:.
Human   496 LNEPESR-PYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNG-VHKGCRTQHT 558

  Fly   720 PWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPE 784
            ||||||.|....| |:.|.||..:... ...:|.||.|:||..||.|||||::.:.||||:|.|:
Human   559 PWADGTECEPGKH-CKYGFCVPKEMDV-PVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPK 621

  Fly   785 NGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE----KDAC 845
            ||||||.|.|.|::||||..|.....|.|::||...:|::.||.|:.|:.:|||||.    ||.|
Human   622 NGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRC 686

  Fly   846 KLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDT 910
            |||||:.....|:.|:..|.|||.|..|:.|.||.|:||.||||:.|||.|:.||||||.|.|.:
Human   687 KLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSS 751

  Fly   911 CHEVTGNLLVSNLLGLNDGNEPNKTLYY----VTRIPKGASNIIITQRGY----PDQNFIVLTDD 967
            |..|.|..               .|::|    |.|||.||:||.:.|..:    .|.|::.|:..
Human   752 CKTVAGTF---------------NTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSS 801

  Fly   968 RDNELLNGKFLKTYPLKFVYAG-VTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLD--VSPSK 1029
            :...||||.|:.|...:.:..| ..::|:||.:.||::|:|.  ::.::|::|::|:.  .:|..
Human   802 KGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTD--RIEQELLLQVLSVGKLYNPDV 864

  Fly  1030 RQDTVLLSYSYTI---DKPPDYEAEVEIYRWEMQAP-SNCDSLCEGRSHRLPACISTTQGVKVAP 1090
            |       ||:.|   |||       :.:.|....| ..|...|:|...|...|...:..:.|:.
Human   865 R-------YSFNIPIEDKP-------QQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSD 915

  Fly  1091 QFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSY 1155
            |.||:...|......|.|||.|...|.|.|||||.|| ||.|.....|.:......::..||..:
Human   916 QRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGF 979

  Fly  1156 CKLKFDVAYHE----ECREGCWVLSEWSTCSKSCGTGSQQREA---------------------- 1194
            |......:..|    ||..|.|..|.|:.|||||..|:|:|.|                      
Human   980 CSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVT 1044

  Fly  1195 -----------------------------H----CYLHNSRVSDDLCNPRTKPHLNTLIGICNTE 1226
                                         |    |.....|::|.:|:|.|||   |.:..|...
Human  1045 IQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKP---TSMQTCQQP 1106

  Fly  1227 SCPTYTKSPNALAVSNWVIGEWGECNEWC---EKTRSVSCSHPYGIG----------C-GSRKPK 1277
            .|            ::|..|.||:|:..|   .:.|:|.|.    ||          | .:.:|.
Human  1107 EC------------ASWQAGPWGQCSVTCGQGYQLRAVKCI----IGTYMSVVDDNDCNAATRPT 1155

  Fly  1278 DVRKC----CH-------------------------------------IKYTS------------ 1289
            |.:.|    ||                                     ::|.|            
Human  1156 DTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADES 1220

  Fly  1290 -------------------------DWTDCSVQCGEGVKRK-------------KQSCTRVYKPD 1316
                                     ||:.|||.||:|...:             :..|.:.|.|:
Human  1221 ACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPE 1285

  Fly  1317 V----------------------------------------------------------PGTRKR 1323
            .                                                          .|..:|
Human  1286 TDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQR 1350

  Fly  1324 RVYV--DES-YCISRKVHRPK------------------------------LRT----------- 1344
            ||.|  ||: |..:..|.|.|                              :||           
Human  1351 RVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGE 1415

  Fly  1345 -------------------TTKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKH 1390
                               .|.:|..:..|:...|..|...|...::.|:|.|.:..|..:|..:
Human  1416 RFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDY 1480

  Fly  1391 CDAKKRPSKRRIC--NNCVRRQSRVISQC--NC-EGVEKRRDFC-FNSHKGRIA----------- 1438
            |....:|...|.|  ..|.:.::...|||  :| .||::|...| ..:||  ||           
Human  1481 CKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHK--IARETECNPYTRP 1543

  Fly  1439 ----------CP------------------------------------------TRARVERHSC- 1450
                      ||                                          ::..|:|.|| 
Human  1544 ESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCS 1608

  Fly  1451 -----------------------------------------------------TPPPH---CRRR 1459
                                                                 |.||.   |..|
Human  1609 LQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673

  Fly  1460 SA-------IGS----SISSRPRGTGVSSSRSLNSIGGS-------------RNRGT-------- 1492
            ..       :|:    |:|.   |.|| ..||:..:...             ..|.|        
Human  1674 DCPVSATWRVGNWGSCSVSC---GVGV-MQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCE 1734

  Fly  1493 -PRSCADLKEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVNV--DPQENYSIYYEYRTKQ 1554
             |::|.::|.:.|.::||.|.|.:|.:::.|:|.||:|..|:|||.:  ...||:|..|.:|...
Human  1735 LPQNCKEVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHN 1799

  Fly  1555 TNSCPPESRGHEYYNDQN------------SGRTHFRKLRLNITDLRIMDNDFKFA-DSRGLAQK 1606
            ...||        ||...            :|.:.|:|:|:::|.::|:..|.:|| .|.|....
Human  1800 PTECP--------YNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVP 1856

  Fly  1607 LGSAGDCYNRIGQCPQGDFSINMKDTDFSIRPGTVWRMHGQYSVMKRISEFDTTTQMRRGFCGGY 1671
            ..:|||||: ..:||||.||||:..|..|:.....|...|.|:|.......|.|..:  |.||||
Human  1857 FATAGDCYS-AAKCPQGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVV--GKCGGY 1918

  Fly  1672 CGGCYIAPDSGLYLDV 1687
            ||.|  .|.||..|:|
Human  1919 CGKC--TPSSGTGLEV 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 32/112 (29%)
ZnMc_ADAMTS_like 455..655 CDD:239801 95/209 (45%)
Reprolysin 457..655 CDD:279729 94/205 (46%)
Salp15 <696..745 CDD:288931 20/48 (42%)
TSP1 754..806 CDD:214559 31/51 (61%)
ADAM_spacer1 937..1042 CDD:283607 34/115 (30%)
TSP1 1172..1229 CDD:214559 23/111 (21%)
GON 1495..1687 CDD:285848 70/206 (34%)
ADAMTS9NP_891550.1 Pep_M12B_propep 73..206 CDD:279848 42/148 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 192..242 11/57 (19%)
Cysteine switch. /evidence=ECO:0000250 221..228 3/14 (21%)
Reprolysin 293..499 CDD:279729 96/211 (45%)
ZnMc_ADAMTS_like 293..496 CDD:239801 95/208 (46%)
TSP1 591..642 CDD:214559 31/50 (62%)
Spacer 753..877 41/154 (27%)
ADAM_spacer1 753..871 CDD:283607 37/141 (26%)
TSP1 1001..1054 CDD:214559 12/52 (23%)
TSP1 1059..1103 CDD:214559 10/46 (22%)
TSP1 1114..1166 CDD:214559 14/55 (25%)
TSP1 1186..1239 CDD:214559 2/52 (4%)
TSP1 1239..1296 CDD:214559 11/56 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1330 0/40 (0%)
TSP1 1332..1384 CDD:214559 11/51 (22%)
TSP1 1386..1440 CDD:214559 3/53 (6%)
TSP1 1445..1499 CDD:214559 13/53 (25%)
TSP1 1504..1555 CDD:214559 12/52 (23%)
TSP1 1562..1613 CDD:214559 4/50 (8%)
TSP1 1615..1676 CDD:214559 5/60 (8%)
GON 1738..1934 CDD:285848 71/208 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 120 1.000 Domainoid score I5764
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 609 1.000 Inparanoid score I926
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48392
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 1 1.000 - - FOG0004456
OrthoInspector 1 1.000 - - otm42007
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2551
SonicParanoid 1 1.000 - - X3160
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1312.910

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