DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and adamts6

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_017213499.1	Gene:	adamts6 / 569099	ZFINID:	ZDB-GENE-091113-9	Length:	1116	Species:	Danio rerio

Alignment Length:	1120	Identity:	331/1120 - (29%)
Similarity:	507/1120 - (45%)	Gaps:	201/1120 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHL---GCFYSGYVED 357
            |.|:.:|:..||.|..:.:.|..|...         |:.|.:   ..:.:|.   .|.|.||:.|
Zfish    84 YKLSAYGKHFHLNLTLNPNLVSKHFTV---------EYWGKD---GLDWQHSVVDNCHYVGYLLD 136

  Fly   358 D-PHSMVSVSLCGGMTGYIKTSFGALLIQP---VNRTSSDEVLHR-----VFRKSQRNARHAVSK 413
            . ..:.|::|.|.|:.|.|.|.....||:|   ::|..|| |.|.     :::|:...:....||
Zfish   137 QYSTTKVALSNCKGLHGVITTEDEQYLIEPLKNISRNFSD-VNHEGQPHVIYKKTSIPSPQEPSK 200

  Fly   414 -FELGLDDFMSKLEQVQEEEQKSKSRKLN---------------RKKRHYADVDNQVYTLEVLIA 462
             |..|:.|.     .|...:..:.:.|||               |::|   .|.::.: :|.|:.
Zfish   201 EFSCGVSDL-----TVNRTQFYNTNPKLNPDFPVLGVDSLMGAHRQRR---SVSSERF-VETLVV 256

  Fly   463 VDNSMKQFHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISL----PNINDQTHSSNEM 522
            .|..|..:|| :|::.|||.:|:||:.::.|||:||.:.|::.|||.|    ||: :..|.:::.
Zfish   257 ADKMMVGYHGRKDIEHYILSVMNIVAKLYRDASLGNVVNIIVTRLIVLTEDQPNL-EINHHADKS 320

  Fly   523 LKHFCQF-------------INQSGY-ERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SS 572
            |..||::             |.::|. ..|.|:||||..|| :...|.|..||||.:..:|. ..
Zfish   321 LDSFCKWQKSILSHQGDGNSIPENGIAHHDNAVLITRYDIC-TYKNKPCGTLGLASVAGMCEPER 384

  Fly   573 SCSIVQDTGLPTAFTMAHELGHILNMNHDD-DDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWS 636
            ||||.:|.||.:|||:|||:||...||||. .:.|     ....::...:|::.:..:.:|:|||
Zfish   385 SCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSC-----GTKGHETAKLMAAHITANTNPFSWS 444

  Fly   637 KCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERL-----PGEIYSLDAQCQLSFGNDFGYCPTDE 696
            .||:.:::.||:....:||:..     |...:.|     ||::|..|.||:..:|.....|...|
Zfish   445 ACSKDYITSFLDSGRGTCLDNE-----PLKRDFLYPTVAPGQVYDADEQCRFQYGASSRQCKYGE 504

  Fly   697 ECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSS---GHWCQRGKCVSNKHGYG---RQVNGGWG 755
            .|:.|||.    :.:.:|.::::|.|:||.|.::   ..||.:|:||:    :|   :.|:|.||
Zfish   505 VCRELWCL----SKSNRCVTNSIPAAEGTLCQTNTIEKGWCYQGECVA----FGTWPQSVDGSWG 561

  Fly   756 PWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQC--- 817
            |||.:..||.||||||..|.|.|:.|.|..|||||.|.||:||||||..||.||.|.||:||
Zfish   562 PWTVWGECSRTCGGGVSSSMRHCDSPAPSGGGKYCLGERKRYRSCNTDACPEGSRDFREKQCADF 626

  Fly   818 --YAMNGRNMNIP-----GVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSF 875
              ....|:..|..     ||.|            |.|.|..:....|......|.|||.|..||.
Zfish   627 DSLPFRGKYYNWKPYTGGGVKP------------CALNCLAEGYNFYTERSPAVIDGTRCQGDSL 679

  Fly   876 DKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVT 940
            |.|:||.|:..||||.|.|.||.|:|.||.|...|| |:|..|...:|        |......|.
Zfish   680 DICINGECKHVGCDNILGSDAKEDRCRVCGGDGSTC-ELTEGLFNDSL--------PRGGYMEVV 735

  Fly   941 RIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQY---TGSSSVVE 1002
            :||||:.:|.|.:... .:|:|.|..:.|:..:||.:...:|.||..||....|   |.....:|
Zfish   736 QIPKGSVHIEIREVAV-SKNYIALKSEGDDYYINGAWTIDWPRKFDIAGTAFHYKRPTDEPESLE 799

  Fly  1003 QVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEI-YRWEMQAPSNCD 1066
            .:..|     ..:|:|.::       .::..:.:.|.:.:........:.|: :.|.....|.|.
Zfish   800 ALGAT-----MENLVVMVL-------LQEQNLGIQYKFNVPIQRTGSGDNEVGFSWHHLPWSECS 852

  Fly  1067 SLCEGRSHRLP-ACISTTQGVKVAPQFCDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGEL 1129
            :.|.|.|.:.. .|........|...:||:.:.|..:.|.|||: |.....:...|||...| :.
Zfish   853 ATCAGGSQKQEVVCKRLDDNSVVQNSYCDQDSKPPGNQRRCNTEPCPPEWFIGDWSECGKTC-DG 916

  Fly  1130 GTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEEC-REGC---WVLSEWSTCSKSCGTGSQ 1190
            |.|.:|..|::.....:...:.| |:| |.......|.| .:.|   ||..:||.|:..||.|.:
Zfish   917 GIRTRTVLCIRKINPAEEETLED-SHC-LTHRPIEQESCNNQSCPPQWVTLDWSECTPKCGPGFK 979

  Fly  1191 QREAHCYLHNSRVSD-------DLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEW 1248
            .|...|     :.||       .||:..:||.:...   |:...||.          ..|:.|||
Zfish   980 HRIVLC-----KSSDLTKTFPAALCSDHSKPPVRIR---CSLGRCPP----------PRWIPGEW 1026

  Fly  1249 GECNEWC---EKTRSVSC----SHPYGIGCGSRKPKDVRKC---CHIKYTSDWTDCS-----VQC 1298
            |:|:..|   ::.|:|.|    ..|......|.:|..:::|   |.....|...:|.     ..|
Zfish  1027 GQCSAQCGLGQQMRTVQCLSYTGQPSSECLDSLRPNTMQQCESKCDSTPISGGDECKDVNKVAYC 1091

  Fly  1299 GEGVKRKKQSCTRVY 1313
            ...:|.|  .|:|.|
Zfish  1092 PLVLKFK--FCSRAY 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	28/104 (27%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/220 (34%)
		Reprolysin	457..655	CDD:279729	75/218 (34%)
		Salp15	<696..745	CDD:288931	16/51 (31%)
		TSP1	754..806	CDD:214559	32/51 (63%)
		ADAM_spacer1	937..1042	CDD:283607	25/107 (23%)
		TSP1	1172..1229	CDD:214559	18/66 (27%)
		GON	1495..1687	CDD:285848
adamts6	XP_017213499.1	Pep_M12B_propep	40..187	CDD:307618	31/115 (27%)
		ZnMc_ADAMTS_like	249..464	CDD:239801	76/222 (34%)
		TSP1	560..612	CDD:214559	32/51 (63%)
		ADAM_spacer1	719..828	CDD:310520	28/129 (22%)
		TSP1	847..899	CDD:214559	14/51 (27%)
		TSP1	901..959	CDD:214559	14/60 (23%)
		TSP1	1021..1068	CDD:214559	13/46 (28%)
		PLAC	1082..1114	CDD:312271	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820