DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and adamts1

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_021331598.1	Gene:	adamts1 / 565145	ZFINID:	ZDB-GENE-070814-1	Length:	1026	Species:	Danio rerio

Alignment Length:	1090	Identity:	343/1090 - (31%)
Similarity:	497/1090 - (45%)	Gaps:	224/1090 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPG--------PET---EAEAEQRHLGC 349
            |.|:|||:::.|.|..|.:|:                .||        |||   ::..|.|   |
Zfish    54 YRLDVFGKRMVLALEPDQTFL----------------APGFVFQMVGKPETGEFDSAGEAR---C 99

  Fly   350 FYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRT--SSDEVLHRVFRKS------QRN 406
            |:||.|..|..|..:::||.|:.|..........|||.|.|  ::|...|.:.|::      :..
Zfish   100 FFSGTVNGDELSSAAINLCKGLHGGFSVGGEEYFIQPENSTGAATDRDTHTIRRRTPGILAEESG 164

  Fly   407 ARHAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYAD--VDNQVYTLEVLIAVDNSMKQ 469
            ::..|::.|          |:|.|:...:.|:....|..|.:.  |....| ||::|..|.||.:
Zfish   165 SKCGVNEEE----------ERVTEKPHTTHSKPSESKAHHRSRRFVSTPRY-LEIMIVADQSMAE 218

  Fly   470 FHGEDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQTH----SSNE--MLKHFCQ 528
            |||..|:||:|.:|::.|.::...:|.|||.:.:|:|:.   ::|:.|    |:|.  .|:.|||
Zfish   219 FHGAQLKPYLLTIMAVASRLYRHPTIHNSITLAVVKLLV---VHDEEHGPHVSTNAALTLRSFCQ 280

  Fly   529 FINQSGY-------ERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTA 585
            :..|...       ..|||:|.||:.:||:   ..|..||:|::||.|. ..||||::|.||..|
Zfish   281 WQKQHNQPSDRHPEHYDTAVLFTRKDLCGA---HSCDTLGMADVGTACDPDRSCSIIEDDGLQAA 342

  Fly   586 FTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKT 650
            ||:||||||:.||.|||..:|   .:...:....|:|:|.:........||.||...|:.||:..
Zfish   343 FTVAHELGHVFNMPHDDAKQC---ASVNGDQWGAHMMASTLSNLNQLDPWSPCSALMVTSFLDNG 404

  Fly   651 DKSCL--ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP-TDEECKRLWCNRTSGNSNE 712
            ...||  :......:|   :.|||.:|..|.||:|:||.:..:|| ....|..|||..||.|...
Zfish   405 HGQCLLDKPQKPEELP---QTLPGSVYDADRQCRLTFGEESQHCPDLSSTCAALWCTVTSANGLL 466

  Fly   713 QCASSNLPWADGTPCGSSGHWCQRGKCVSNKHG--YGRQVNGGWGPWTPFTPCSLTCGGGVQESR 775
            .|.:.|.||||||||||:. :|..|:|:|....  |...||||||.|..:..||.|||||||.|.
Zfish   467 VCQTKNFPWADGTPCGSNS-YCMAGQCLSKTEAAKYETPVNGGWGSWGSWGDCSRTCGGGVQYSF 530

  Fly   776 RECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGS-MDPREQQCYAMNGRNMNIP-GVNPDTKWVP 838
            |:|..|.|:||||||.|.|.:||||||..||..: :..||:||.|.|..:..:. |.....:|||
Zfish   531 RDCVNPRPKNGGKYCEGKRIQYRSCNTETCPDSNGLTFREEQCLAHNDLSSQVSLGSGEGVEWVP 595

  Fly   839 KY----EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLD 899
            ||    .||.|||.||......:|:||..|.|||.|..||...||.|.|..||||..:.|..:.|
Zfish   596 KYAGVSPKDRCKLVCRAKGTGYFFILKPKVADGTPCTPDSTSVCVQGQCVKAGCDRVIGSDKRFD 660

  Fly   900 KCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY-VTRIPKGASNIIITQRGY----PDQ 959
            |||:|.|...||.:|:|::            |..:..|. |..||.||:::.:.||.:    .|.
Zfish   661 KCGICGGDGSTCKKVSGSM------------ERARPGYQDVVTIPAGATHLDVKQRSFGGRSQDN 713

  Fly   960 NFIVLTDDRDNELLNGKF-LKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISL 1023
            :::.:.....:.||||.: |.|........|..::|:|||.::|::.:..  .|...|.:|::|:
Zfish   714 SYLAVRRQDGSYLLNGDYKLTTLETDISVKGALLRYSGSSVLLERLRSFA--PLPEPLTIQVLSV 776

  Fly  1024 DVSPSKRQDTVLLSYSYTIDKP-----PDYEA-----EVEIYRWEMQAPSNCDSLCEGRSHRLPA 1078
            ..||..|     :.|||...:|     |...|     :.|   |.:.....|...|.|
Zfish   777 GESPRPR-----VKYSYFAPRPNGSNRPSINAISKAVDAE---WFLGEWGTCSKTCGG------- 826

  Fly  1079 CISTTQGVKVAPQFC-DKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTF 1142
                  |::.....| |....|       :.:|...|...|..:|:.
Zfish   827 ------GIQTRDVMCLDSKRRP-------SKNCVDELRPASSRQCAL------------------ 860

  Fly  1143 TNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDD- 1206
                                   ::|  ..|.|.||.||||:||.|.|.|:..|..||.|.|.|
Zfish   861 -----------------------QDC--PFWFLGEWGTCSKTCGGGIQTRDVMCLDHNRRPSKDC 900

  Fly  1207 --LCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCE---KTRSVSC--- 1263
              |..|.::.        |..:.||.            |.:||||.|::.|.   :.|.|.|
Zfish   901 VELHPPSSRQ--------CALQDCPA------------WFLGEWGTCSKTCGGGIQKRDVMCLDH 945

  Fly  1264 SHPYGIGCGSRKPKDVRKC----CHIKYTSDWTDCSVQCGEGVKRKKQSC 1309
            :|.....|...:|...|:|    |......:|::||..||.|.:::..||
Zfish   946 NHRPSEDCVELRPASSRQCALQDCPFWLPGNWSECSRTCGRGFRKRTLSC 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	32/110 (29%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	78/213 (37%)
		Reprolysin	457..655	CDD:279729	77/211 (36%)
		Salp15	<696..745	CDD:288931	23/48 (48%)
		TSP1	754..806	CDD:214559	31/51 (61%)
		ADAM_spacer1	937..1042	CDD:283607	31/110 (28%)
		TSP1	1172..1229	CDD:214559	22/59 (37%)
		GON	1495..1687	CDD:285848
adamts1	XP_021331598.1	Pep_M12B_propep	29..136	CDD:307618	28/100 (28%)
		ZnMc_ADAMTS_like	204..410	CDD:239801	79/215 (37%)
		ADAM_CR	423..495	CDD:326582	34/72 (47%)
		TSP1	517..561	CDD:214559	28/43 (65%)
		ADAM_spacer1	673..791	CDD:310520	34/136 (25%)
		TSP1	811..864	CDD:214559	14/118 (12%)
		TSP1	869..917	CDD:214559	20/55 (36%)
		TSP1	922..970	CDD:214559	14/47 (30%)
		TSP1	972..1026	CDD:214559	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8625
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24937
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920