DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adgrb1a

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_009290826.1	Gene:	adgrb1a / 563527	ZFINID:	ZDB-GENE-060607-12	Length:	1610	Species:	Danio rerio

Alignment Length:	944	Identity:	172/944 - (18%)
Similarity:	253/944 - (26%)	Gaps:	422/944 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 AQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLP---WADGTPCGSSGHWCQR-GKC 739
            |.||:       .|...|:|      .|..:|...|.....|   | |..|.....:.|.| |..
Zfish   171 AACQM-------LCQWLEDC------LTYSSSTRPCGIMQTPCQCW-DQPPLDKESNGCYRDGVF 221

  Fly   740 VSN-----KHGYGRQVN-GGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYR 798
            :.|     |.|.....| |||..|..:..||..||||||:..|.|..|..|  ...|.|..::.|
Zfish   222 LENCIPVVKEGASETDNSGGWSGWGNWAECSSECGGGVQKRTRNCQSPPDE--AYLCEGVLEEGR 284

  Fly   799 SCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSM 863
            .||...|    :..|:   |:..|:     |::|     .||:.                |.::|
Zfish   285 PCNAQPC----IGYRQ---YSSKGQ-----GLSP-----VKYKG----------------MQEAM 316

  Fly   864 VTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLND 928
            :..|                |.......|.|:
Zfish   317 LGKG----------------RLGSRSQSLRSV--------------------------------- 332

  Fly   929 GNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQ 993
                                                 |.|..|
Zfish   333 -------------------------------------DSRKRE---------------------- 338

  Fly   994 YTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWE 1058
                                        ..|.:.|.:|.      |.|:|.|...|       |
Zfish   339 ----------------------------DSDKTRSGQQS------SQTVDSPSGEE-------W- 361

  Fly  1059 MQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISEC 1122
             .|.|.|.:.| ||...|...|:|.:        :..:.:.|..:.|.||.        |::  |
Zfish   362 -SAWSVCSATCGEGWQSRTRFCVSVS--------YSTQCSGPLREQRPCNN--------TAV--C 407

  Fly  1123 SAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCW-VLSEWSTCSKSCG 1186
            .||.                                   :..|     |.| ..:.||.||.:||
Zfish   408 PAAL-----------------------------------ITEH-----GAWGEWTPWSLCSSTCG 432

  Fly  1187 TGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGEC 1251
            .|.::|...|     :......||...|...|  ..||...||              |.|.|
Zfish   433 RGYRERNRSC-----KPPQFGGNPCDGPEKQT--KFCNIAVCP--------------VDGVW--- 473

  Fly  1252 NEWCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPD 1316
            |||                                  |.|:.||..|..|..::.:.|.   .|.
Zfish   474 NEW----------------------------------SGWSSCSSTCSNGTMQRIRECN---GPS 501

  Fly  1317 VPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNA-SDWRRCPADCSEEYQTRDVRC-- 1378
            ..|...:..:.:...|..|:            |.::.:|.. |.|..|...|....|.|...|
Zfish   502 YGGLECQGEWHETRDCFLRE------------CPVDGQWQLWSTWSGCTKTCGGGSQQRQRLCYG 554

  Fly  1379 -----ESFQGDGVEDKHCDAKKRPSKRRIC-----NNCVRRQS----------------RVISQC 1417
                 |:..||..|.:.|:.|:.|....||     :|.|.:::                .::.:|
Zfish   555 PFFGGEACPGDREEVRRCNEKRCPEPHEICDEENFSNVVWKKTPAGDTAAVRCPPNAVGLILRRC 619

  Fly  1418 NC--EGVEKRRD----FCFNSHKGRIACPTRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVS 1476
            :.  ||:....:    .|.::....|...||..:.:         .:|..:|..:|.      |.
Zfish   620 SLDNEGIAYWENPTYMKCVSNDYRSIQTLTRDHLSK---------AQRGLVGDGVSE------VM 669

  Fly  1477 SSRSLNSIGGSRNRGTPRSCAD-LKEM-----HGYNKDGNYQL-------------EVRSRMVHI 1522
            :...:.|..|:...|...:..| ||.|     ..|....|..:             |.|.|....
Zfish   670 TKLRVTSSDGTSYSGDLLAIIDVLKNMTEIFRRSYYSPSNADMRNFVQSVSNLLMEENRDRWEEA 734

  Fly  1523 YCHGMN----SRTPQEYVNV------DPQENYSI 1546
            ...|.|    .|..:::|:|      |.|:.|.:
Zfish   735 QLLGPNVKELFRLVEDFVDVISLRMKDFQDTYEV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931	14/57 (25%)
		TSP1	754..806	CDD:214559	19/51 (37%)
		ADAM_spacer1	937..1042	CDD:283607	7/104 (7%)
		TSP1	1172..1229	CDD:214559	16/57 (28%)
		GON	1495..1687	CDD:285848	17/81 (21%)
adgrb1a	XP_009290826.1	TSP1	242..291	CDD:214559	19/50 (38%)
		TSP1	360..408	CDD:214559	16/74 (22%)
		TSP1	418..468	CDD:214559	16/56 (29%)
		TSP1	473..523	CDD:214559	15/101 (15%)
		TSP1	528..578	CDD:214559	14/49 (29%)
		HRM	580..646	CDD:295297	8/65 (12%)
		GAIN	665..860	CDD:293098	22/110 (20%)
		GPS	886..930	CDD:280071
		7tm_4	944..1211	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900