Protein Alignment AdamTS-A and paplna

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_005169942.1
• Gene: paplna / 562930
• ZFINID: ZDB-GENE-070815-4
• Length: 1187
• Species: Danio rerio
• Alignment Length: 918
• Identity: 211/918 - (22%)
• Similarity: 300/918 - (32%)
• Gaps: 278/918 - (30%)

  Fly   750 VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPE--NGGKYCTGSRKKYRSCNTHQCPPGSMDP 812
            :...||.|:.:..||.:|||||....|.|   |..  :||..|.|..|.|||||...||.||.|.
Zfish    20 IGDNWGEWSSYGECSRSCGGGVTMRTRRC---VTHRTDGGHSCVGPDKSYRSCNIQDCPEGSRDF 81

  Fly   813 REQQCYAMNGRNMNIPGVNPDTKWVPKY-EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFD 876
            ||:||...:|.:..    ....||:|.| .::.|:|.|....:..|:..||.|.|||.|.....|
Zfish    82 REEQCSQFDGTDFQ----GKRYKWLPYYGGENPCELNCIPRGENFYYRQKSSVVDGTPCRPGGKD 142

  Fly   877 KCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNL-LGLNDGNEPNKTLYYVT 940
            .||:|:|:..|||:.|.|..:.|.|..|.|...:|..:..:..:.|| .|.|.          :.
Zfish   143 ICVDGLCKRLGCDHMLESPQEEDACLQCGGDGQSCSRLKNSFSMRNLPKGYNQ----------MF 197

  Fly   941 RIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQY----------- 994
            .||.||:.|.|.:. .|.:|::.:.:.|....|||.::.........||..:.|
Zfish   198 IIPVGATTISIKET-LPTRNYLAIKNLRGEYYLNGHWVIDLSRAASIAGTVLHYQRGREGEKSPE 261

  Fly   995 --TGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRW 1057
              ||.....|            .|::::|:.:|                 ::..|||
Zfish   262 MITGRGPTTE------------PLVIELITQEV-----------------NEGVDYE-------- 289

  Fly  1058 EMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISEC 1122
                            :.||      .|
Zfish   290 ----------------YYLP------NG------------------------------------- 295

  Fly  1123 SAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGT 1187
                   |:.|..|                                    |....||.|||.||:
Zfish   296 -------GSTEGYY------------------------------------WSYGSWSACSKECGS 317

  Fly  1188 GSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCP-------TY-------TKSPNA- 1237
            |.|.|...|...:...||.||....:|..|.   .||.:.||       .|       |::|..
Zfish   318 GYQSRLVFCTFEDEAYSDYLCASLPRPLSNR---TCNEQQCPQTRRMAYVYEAQLWRPTETPRVY 379

  Fly  1238 LAVSNWVIGEWGECNEWCE---KTRSVSC-SHPYGIGCGSRKPKD-----------------VRK 1281
            :.|.:|..|||..|...|.   :.|.|.| ||.   ..|||..:|                 ::|
Zfish   380 VQVYSWTAGEWSPCPVTCGGGLQARRVECMSHD---STGSRLVEDSQCTAYTPRPLSQQNCNMQK 441

  Fly  1282 CCHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLR-TT 1345
            |......| |:.|||.||.|.:.:...|.        |:....|   |.|....:...|:.: ..
Zfish   442 CAQYSIYS-WSQCSVTCGSGKQTRDVVCI--------GSDGASV---EDYACGNQPKPPREQICE 494

  Fly  1346 TKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICN--NCVR 1408
            ...||....|:..||..|...|....:.|.|.|...|.:....:.|..|.:|.....||  .|.|
Zfish   495 MPMCRSPIAWHIGDWGLCSKSCGSGLRERQVICSDRQRNLYRAEECQGKPKPPTVESCNAQPCYR 559

  Fly  1409 RQSRVISQCNCEGVEKR-RDFCFNSHKGRIACP-TRARVERHSCTPPPHCRRRS----AIGSSIS 1467
            .| .|.|..:..|.:.. ..|...|....:..| ..|....|.....|||.:..    ..|.:.:
Zfish   560 PQ-EVPSMQDPTGHDNTLHGFMPYSEDPLLEIPQNNAAHSPHGTALTPHCSQTQYGCCPDGRTPA 623

  Fly  1468 SRPRGTGVSSSRSLNSIGGSRNRGTPRSCAD-LKEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRT 1531
            |.|:..|....:...|...||.    ..|.| :....|.|.:|         ....:.|..:|..
Zfish   624 SGPQHQGCPQDQGQPSCTWSRY----GCCHDGVTVAQGQNMEG---------CPDAWTHWSSSSD 675

  Fly  1532 PQEYVNVD-PQENYSIYYE-----------------YRTKQTNSC-------PPESRGHEYYNDQ 1571
            ......|| ....|...|:                 ..|:::.||       |.:.....:|.|:
Zfish   676 TVPSAPVDCHSSTYGCCYDGVTAASGTHGEGCSNPPSNTQRSLSCDLPNTVGPCDQWTSRFYFDR 740

  Fly  1572 NSGR-THF 1578
            ::.| .||
Zfish   741 SASRCLHF 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254
		ZnMc_ADAMTS_like	455..655	CDD:239801
		ADAMTS_CR_2	671..740	CDD:465496
		TSP1	754..806	CDD:214559	23/53 (43%)
		ADAMTS_CR_3	815..911	CDD:437068	32/96 (33%)
		TSP1	1172..1229	CDD:214559	20/56 (36%)
		TSP1_ADAMTS	1243..1282	CDD:465950	15/59 (25%)
		TSP1_ADAMTS	1355..1405	CDD:465950	14/51 (27%)
		GON	1493..1687	CDD:462559	20/113 (18%)
paplna	XP_005169942.1	TSP1	24..75	CDD:214559	23/53 (43%)
		ADAMTS_CR_3	80..177	CDD:437068	35/100 (35%)
		ADAMTS_spacer1	181..293	CDD:461796	28/175 (16%)
		TSP1_ADAMTS	303..355	CDD:465950	20/54 (37%)
		TSP1_ADAMTS	385..442	CDD:465950	15/59 (25%)
		TSP1_ADAMTS	450..498	CDD:465950	13/58 (22%)
		TSP1_ADAMTS	504..557	CDD:465950	14/52 (27%)
		Kunitz_papilin	720..770	CDD:438678	7/29 (24%)
		Ig_3	839..906	CDD:464046
		Ig	959..1034	CDD:472250
		Ig strand B	963..967	CDD:409353
		Ig strand C	979..983	CDD:409353
		Ig strand E	1000..1004	CDD:409353
		Ig strand F	1014..1019	CDD:409353
		Ig strand G	1027..1030	CDD:409353
		Ig	1039..1121	CDD:472250
		Ig strand B	1055..1059	CDD:409353
		Ig strand C	1067..1071	CDD:409353
		Ig strand E	1090..1094	CDD:409353
		Ig strand F	1104..1109	CDD:409353
		Ig strand G	1115..1118	CDD:409353
		PLAC	1142..1173	CDD:462560