DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and paplna

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_005169942.1	Gene:	paplna / 562930	ZFINID:	ZDB-GENE-070815-4	Length:	1187	Species:	Danio rerio

Alignment Length:	918	Identity:	211/918 - (22%)
Similarity:	300/918 - (32%)	Gaps:	278/918 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   750 VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPE--NGGKYCTGSRKKYRSCNTHQCPPGSMDP 812
            :...||.|:.:..||.:|||||....|.|   |..  :||..|.|..|.|||||...||.||.|.
Zfish    20 IGDNWGEWSSYGECSRSCGGGVTMRTRRC---VTHRTDGGHSCVGPDKSYRSCNIQDCPEGSRDF 81

  Fly   813 REQQCYAMNGRNMNIPGVNPDTKWVPKY-EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFD 876
            ||:||...:|.:..    ....||:|.| .::.|:|.|....:..|:..||.|.|||.|.....|
Zfish    82 REEQCSQFDGTDFQ----GKRYKWLPYYGGENPCELNCIPRGENFYYRQKSSVVDGTPCRPGGKD 142

  Fly   877 KCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNL-LGLNDGNEPNKTLYYVT 940
            .||:|:|:..|||:.|.|..:.|.|..|.|...:|..:..:..:.|| .|.|.          :.
Zfish   143 ICVDGLCKRLGCDHMLESPQEEDACLQCGGDGQSCSRLKNSFSMRNLPKGYNQ----------MF 197

  Fly   941 RIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQY----------- 994
            .||.||:.|.|.:. .|.:|::.:.:.|....|||.::.........||..:.|
Zfish   198 IIPVGATTISIKET-LPTRNYLAIKNLRGEYYLNGHWVIDLSRAASIAGTVLHYQRGREGEKSPE 261

  Fly   995 --TGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRW 1057
              ||.....|            .|::::|:.:|                 ::..|||
Zfish   262 MITGRGPTTE------------PLVIELITQEV-----------------NEGVDYE-------- 289

  Fly  1058 EMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISEC 1122
                            :.||      .|
Zfish   290 ----------------YYLP------NG------------------------------------- 295

  Fly  1123 SAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGT 1187
                   |:.|..|                                    |....||.|||.||:
Zfish   296 -------GSTEGYY------------------------------------WSYGSWSACSKECGS 317

  Fly  1188 GSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCP-------TY-------TKSPNA- 1237
            |.|.|...|...:...||.||....:|..|.   .||.:.||       .|       |::|..
Zfish   318 GYQSRLVFCTFEDEAYSDYLCASLPRPLSNR---TCNEQQCPQTRRMAYVYEAQLWRPTETPRVY 379

  Fly  1238 LAVSNWVIGEWGECNEWCE---KTRSVSC-SHPYGIGCGSRKPKD-----------------VRK 1281
            :.|.:|..|||..|...|.   :.|.|.| ||.   ..|||..:|                 ::|
Zfish   380 VQVYSWTAGEWSPCPVTCGGGLQARRVECMSHD---STGSRLVEDSQCTAYTPRPLSQQNCNMQK 441

  Fly  1282 CCHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLR-TT 1345
            |......| |:.|||.||.|.:.:...|.        |:....|   |.|....:...|:.: ..
Zfish   442 CAQYSIYS-WSQCSVTCGSGKQTRDVVCI--------GSDGASV---EDYACGNQPKPPREQICE 494

  Fly  1346 TKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICN--NCVR 1408
            ...||....|:..||..|...|....:.|.|.|...|.:....:.|..|.:|.....||  .|.|
Zfish   495 MPMCRSPIAWHIGDWGLCSKSCGSGLRERQVICSDRQRNLYRAEECQGKPKPPTVESCNAQPCYR 559

  Fly  1409 RQSRVISQCNCEGVEKR-RDFCFNSHKGRIACP-TRARVERHSCTPPPHCRRRS----AIGSSIS 1467
            .| .|.|..:..|.:.. ..|...|....:..| ..|....|.....|||.:..    ..|.:.:
Zfish   560 PQ-EVPSMQDPTGHDNTLHGFMPYSEDPLLEIPQNNAAHSPHGTALTPHCSQTQYGCCPDGRTPA 623

  Fly  1468 SRPRGTGVSSSRSLNSIGGSRNRGTPRSCAD-LKEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRT 1531
            |.|:..|....:...|...||.    ..|.| :....|.|.:|         ....:.|..:|..
Zfish   624 SGPQHQGCPQDQGQPSCTWSRY----GCCHDGVTVAQGQNMEG---------CPDAWTHWSSSSD 675

  Fly  1532 PQEYVNVD-PQENYSIYYE-----------------YRTKQTNSC-------PPESRGHEYYNDQ 1571
            ......|| ....|...|:                 ..|:::.||       |.:.....:|.|:
Zfish   676 TVPSAPVDCHSSTYGCCYDGVTAASGTHGEGCSNPPSNTQRSLSCDLPNTVGPCDQWTSRFYFDR 740

  Fly  1572 NSGR-THF 1578
            ::.| .||
Zfish   741 SASRCLHF 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	23/53 (43%)
		ADAM_spacer1	937..1042	CDD:283607	21/117 (18%)
		TSP1	1172..1229	CDD:214559	20/56 (36%)
		GON	1495..1687	CDD:285848	20/111 (18%)
paplna	XP_005169942.1	TSP1	24..75	CDD:214559	23/53 (43%)
		ADAM_spacer1	181..293	CDD:310520	28/175 (16%)
		TSP1	303..356	CDD:214559	20/55 (36%)
		TSP1	388..442	CDD:214559	14/56 (25%)
		TSP1	449..498	CDD:214559	14/60 (23%)
		TSP1	504..557	CDD:214559	14/52 (27%)
		KU	720..771	CDD:238057	7/29 (24%)
		Ig_3	839..906	CDD:316449
		IGc2	960..1022	CDD:197706
		I-set	1039..1121	CDD:333254
		PLAC	1142..1173	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810