DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamts7

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_021333676.1	Gene:	adamts7 / 560364	-ID:	-	Length:	1808	Species:	Danio rerio

Alignment Length:	1002	Identity:	298/1002 - (29%)
Similarity:	457/1002 - (45%)	Gaps:	132/1002 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDD-- 358
            |.|...|:.||..|..:...:....:|..|       :.|.:........|..||:.|.|...
Zfish   110 YYLQYGGQDLHFNLTLNPHLLAPGFLTERR-------YGGLQGSTLHGHGHSLCFFLGDVWSSML 167

  Fly   359 PHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEV--LHRVFRKSQRNARHAVSKFELGLDDF 421
            .....:||.|.|:||..|.|.....|.|:.:...:..  .|.:::      ||||......:...
Zfish   168 KSGQAAVSTCNGLTGLFKLSEEEFFISPLEQEQEESTTQAHAIYK------RHAVQSERQLVQPL 226

  Fly   422 MSK------------LEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-E 473
            ..:            .||.:.:.::.:||: .||:.....:..:.: :|.|:..|..|.::|| :
Zfish   227 FGEHTANATCGVKGGAEQFERQRERWESRQ-QRKRIRQRSISTEKW-VETLVVADPKMVEYHGSK 289

  Fly   474 DLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ---THSSNEMLKHFCQF---INQ 532
            .:..|:|.:|:||:.:|.||||||:|.|.:|||:.|....:.   ||.::..|..||::   ||.
Zfish   290 GVVSYVLSVMNIVAGLFRDASIGNAINIAVVRLVLLEKDEEDLKITHHADNSLHSFCKWQKNINM 354

  Fly   533 SG----YERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHEL 592
            ..    ...|.|:||||:.||.:: .|.|..|||:.:..:|. ..||||.:|||||.|||:||||
Zfish   355 KDDDHPVHHDVAVLITRKDICAAI-NKPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTIAHEL 418

  Fly   593 GHILNMNHD-DDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLE 656
            ||...:.|| :.:.|.|...|.      .:||..:.....|.:||:|||.:::.||::....||:
Zfish   419 GHNFGIQHDGNGNDCEPIGKRP------FVMSPQLLYGTSPPNWSRCSREYITRFLDRGWGWCLD 477

  Fly   657 TSVGAHIPYGTE-----RLPGEIYSLDAQCQLSFGNDFGYC-PTDEECKRLWCNRTSGNSNEQCA 715
            ..     |...|     ..||.:||...||:|.:|:....| ..|..|..|||  |.|::   |.
Zfish   478 DP-----PVRNELDLHPAPPGVLYSAAHQCKLQYGSSSLLCDEVDNICSTLWC--TVGST---CH 532

  Fly   716 SSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQ 780
            |......|||.||.. .||..|:||: |......|:|||..|:.::.||.|||.|||.::|:|..
Zfish   533 SRLDGAVDGTKCGED-KWCFDGECVT-KGTQPESVHGGWASWSDWSDCSRTCGTGVQNAQRDCIN 595

  Fly   781 PVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYEK-DA 844
            |||:.||:||.|.|::||:||...||......|..||...|    .:|......||:....: :.
Zfish   596 PVPKYGGRYCLGERQRYRTCNHESCPVDQPSFRHMQCSRFN----TVPYKGKFYKWIHVNNRVNP 656

  Fly   845 CKLFCR-MDMKVTYFMLKSMVTDGTSC--AVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEG 906
            |:|.|| |:...:..||.::: |||.|  ...|.|.||||||:..|||.|::|.|..|:||||.|
Zfish   657 CELHCRPMNEHFSERMLDTVI-DGTQCYEGSQSRDICVNGICKYLGCDFEIDSDAVEDQCGVCLG 720

  Fly   907 RNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNE 971
            ...||..|......|..||..|          :..||:||.:|.|.:.........:.::|.:..
Zfish   721 NGSTCETVRKTFEDSEGLGYVD----------IGLIPEGARDIRIEEVAEAGNYLALRSNDPEKY 775

  Fly   972 LLNGKFLKTYPLKFVYAGVTMQY--TGSSSVVEQVNTTYS--WKLSRDLIVQIISLDVSPSKRQD 1032
            .|||.:...:..::..||....|  ||....:.....|..  |       :|::..:.:|..|
Zfish   776 FLNGGWTIQWNGEYKAAGTIFTYERTGQLENLSSPGPTMEPVW-------IQLLFQETNPGVR-- 831

  Fly  1033 TVLLSYSYTIDKPPDYEAE----VEIYRWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQF 1092
                 |.|||.:....::.    |..::|...|.:.|.:.| .|...::..|:..|.|: |...:
Zfish   832 -----YEYTISRDTLLDSSNGTAVSYFQWIYGAWTECSATCGTGMQRQIVHCVEKTSGI-VEEHY 890

  Fly  1093 CDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYC 1156
            ||.|..|.....:||.. |..........:||::|||:|.|::|..|:::. .:.....:..:.|
Zfish   891 CDASMRPDDKQTSCNKGLCPAIWWAGDWQKCSSSCGEMGLRKRTVLCIRSL-GLDEQRALQPAEC 954

  Fly  1157 K--LKFDVAYHEECREGC---WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHL 1216
            :  .|.:.......:..|   |....||.||.||.||.:.|:..|..:..  ||  |:|:.||:
Zfish   955 QHLPKPESIIPCNTQVSCPADWTTGSWSECSVSCATGLRIRDVTCRWNTG--SD--CDPKAKPN- 1014

  Fly  1217 NTLIGICNTESCPTYTKSPNALAVSNW 1243
            :|:  .|..:.||..|.      :|:|
Zfish  1015 STM--PCYAQDCPINTD------ISDW 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	24/99 (24%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	78/212 (37%)
		Reprolysin	457..655	CDD:279729	78/210 (37%)
		Salp15	<696..745	CDD:288931	19/48 (40%)
		TSP1	754..806	CDD:214559	25/51 (49%)
		ADAM_spacer1	937..1042	CDD:283607	22/108 (20%)
		TSP1	1172..1229	CDD:214559	20/59 (34%)
		GON	1495..1687	CDD:285848
adamts7	XP_021333676.1	Pep_M12B_propep	68..211	CDD:307618	25/107 (23%)
		ZnMc_ADAMTS_like	270..477	CDD:239801	79/214 (37%)
		ADAM_CR	<513..556	CDD:326582	18/48 (38%)
		ADAM_CR	540..697	CDD:326582	65/163 (40%)
		TSP1	569..621	CDD:214559	25/51 (49%)
		ADAM_spacer1	726..836	CDD:310520	27/133 (20%)
		TSP1	855..910	CDD:214559	15/55 (27%)
		TSP1	976..1025	CDD:214559	19/55 (35%)
		Herpes_U47	<1363..>1441	CDD:283192
		TSP1	1588..1646	CDD:214559
		TSP_1	1651..1695	CDD:326556
		TSP1	1698..1755	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820