DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and adamtsl7

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_017211532.2	Gene:	adamtsl7 / 556634	ZFINID:	ZDB-GENE-070816-2	Length:	643	Species:	Danio rerio

Alignment Length:	644	Identity:	152/644 - (23%)
Similarity:	236/644 - (36%)	Gaps:	142/644 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   887 GCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIII 951
            ||:.     .::|.||||.|...:|....|.:.:|.|         :...:.:..||.||..|.|
Zfish    47 GCEG-----FQVDVCGVCAGDGSSCELFNGTIFLSVL---------SVRYHKILNIPSGALRIKI 97

  Fly   952 TQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTY------SW 1010
             |..:..:|::.|:......::||.::...|.:|..||....|...:.:..:...:.      :.
Zfish    98 -QETHKTRNYLALSMATGESVINGDWVIDRPGQFYAAGTQFTYKRPNEIRSRAGESITAPGPTNQ 161

  Fly  1011 KLSRDLIVQ----IISLDVSPSKRQDTVLLSYSYTIDKP--------PDYE-------------- 1049
            :|:..:|.|    .:..:....|..:|...:|||:...|        ||.|
Zfish   162 ELNLFVIYQQPDAAVYYEYILPKHTNTHSDAYSYSSVLPLVESHGIFPDSENSVGENSLSSFHPN 226

  Fly  1050 ---------AEVEIYRWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDR 1104
                     ..|.:|.|...|.:.|.:.| .|....|..|:.......|....|.....|.....
Zfish   227 QVPSDSVTLEPVPLYSWMAMATTPCSTTCGTGNRQVLFGCVERATQTTVLEDLCSSITHPGPQVE 291

  Fly  1105 ACNTD-CRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIV-------------DMSY 1155
            .|.:. |.....|...||||..||. |.:.:...|.||......|.:|             ..|.
Zfish   292 ECQSQPCPAFWDVGEWSECSKTCGP-GFQYRQVICRQTQGQHGSSTVVVANSMCDDTEMPDTTSV 355

  Fly  1156 CKLKFDVAYHEECREGCW-VLSEWSTCSKSCGTGSQQREAHCYLH-NSRVSDDLCNPRTKPHLNT 1218
            |:||.       |.|  | :.|||:.||..||.|.:.||..|..: ...|||:.||...:|.
Zfish   356 CQLKI-------CSE--WQIRSEWTECSVPCGVGQRSREVVCVDNLGDIVSDEECNMALRPQ--- 408

  Fly  1219 LIGICNTESCPTYTKSPNALAVSNWVIGEWGE-CNEWC---EKTRSVSC------SHPYGIGCGS 1273
                 :.::|      ...:..|:|....|.| |:..|   .::|||.|      |.|.......
Zfish   409 -----DLQNC------DKGVCASSWFYSLWSERCSADCAEGSRSRSVVCLMSQSNSLPLDDCDDE 462

  Fly  1274 RKPKDVRKC----CHIK---YTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESY 1331
            .||.::.:|    |..:   ||..|..||.:||.|.:.:...|.      |..:....|..|:
Zfish   463 DKPDELMQCDLGPCAQRLEWYTGPWGQCSSECGNGTQSRGVVCV------VQNSGHLEVTSDD-- 519

  Fly  1332 CISRKVHRPKLRTTTKSCRI-NC--KWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDA 1393
             :...:.||   .|.:||.: :|  :|..::|..|...|...::.|:|||  .:.|......||.
Zfish   520 -LCSHLPRP---PTAQSCYLKSCAAQWFMTEWSSCSRSCEGGFRVREVRC--LRDDLTSSHDCDP 578

  Fly  1394 KKRPSKRRICNN--CVRRQSRVISQC-----NCEGVEKRRDFCFNSHKGRIACPTRARV 1445
            ...|:|:..||.  |.   .::...|     ||..|.:.| .|..|:.....|.:.:||
Zfish   579 ALEPAKQEKCNTHICT---LQIDESCRDMYYNCVVVVQAR-LCVYSYYRTTCCASCSRV 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559
		ADAM_spacer1	937..1042	CDD:283607	24/114 (21%)
		TSP1	1172..1229	CDD:214559	18/58 (31%)
		GON	1495..1687	CDD:285848
adamtsl7	XP_017211532.2	ADAM_spacer1	82..183	CDD:310520	19/101 (19%)
		TSP1	302..>335	CDD:214559	11/33 (33%)
		TSP1	361..418	CDD:214559	21/72 (29%)
		TSP1	542..593	CDD:214559	15/52 (29%)
		PLAC	601..631	CDD:312271	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810