DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AdamTS-A and adamts9

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_001361725.1 Gene:adamts9 / 493280 XenbaseID:XB-GENE-1013537 Length:1923 Species:Xenopus tropicalis


Alignment Length:2045 Identity:533/2045 - (26%)
Similarity:798/2045 - (39%) Gaps:654/2045 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   170 LLGMLIMFHLGLRSAHKGQEELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEE 234
            |||::|:    ||....|             :.|.....|:||:           ...|:.|...
 Frog     7 LLGLVIL----LRDCAYG-------------AAPLRAPRLYPRQ-----------AKFLEKLGAY 43

  Fly   235 EHSAFVMPTKVYNYSLSEA---DLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQY 296
            |   .|.||:|  ..|.||   ::.::..|.|..||   .....:|.:.|:             |
 Frog    44 E---IVTPTRV--NELGEAFPSNMHFKRTRRSVPNS---RDIDPWAASRTH-------------Y 87

  Fly   297 NLNVFGRQLHLVLRQDASF---VHNHSMTHIRILKEGEEHPGPETEAEA------EQRHLGCFYS 352
            .|:.||:...|.|..::.|   |...|:           |..|.....:      :.:|  ||::
 Frog    88 KLSAFGQHFFLNLTANSGFMAPVFTVSL-----------HGKPRGNQSSYYTDNTDFQH--CFFN 139

  Fly   353 GYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSD--------EVLHR-------VFRK 402
            |:|.........:|||.||.|..|:..|...::|:....|:        .|::|       :.|:
 Frog   140 GHVNHRAEHTAVISLCSGMLGTFKSQDGDYFVEPLLSDDSEYEEEHNKPHVVYRHNPPHRNISRE 204

  Fly   403 SQ----------------------RNARH----AVSKFELGLDDFMSKLEQVQEEEQKSKSRKLN 441
            .|                      :|..|    |::|..||..:.:     ..:.:..:.:|.|.
 Frog   205 EQTCHTAEPTHASDSHAKGGARLEQNDPHSDDQALNKGLLGTQNPL-----FNKADNATGTRTLR 264

  Fly   442 RKKRHYADVDNQVYT--LEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASIGNSIRILLV 504
            ||||..:      |.  :||::..||.|.::||.:||.|:|.|||||:||:.|.||||.|.|.:|
 Frog   265 RKKRFLS------YPRYVEVMVVADNKMVEYHGANLQHYVLTLMSIVASIYKDPSIGNLINIAIV 323

  Fly   505 RLISLPNINDQ------THSSNEMLKHFCQFINQSG-------YERDTAMLITREPICGSVPGKI 556
            :|..   ::|:      :.::...||:||.:.....       ...|||:||||:.||.:  .:.
 Frog   324 KLAV---VHDEQEGPAISFNAQSTLKNFCIWQQSQNNPDDNHPSHHDTAVLITRQDICRA--QEK 383

  Fly   557 CHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQNNNKVLH 620
            |..||||||||||.. .||||.:|.||.||||:||||||:.||.|||.:||    ..::.....|
 Frog   384 CDTLGLAELGTVCDPYRSCSISEDNGLSTAFTIAHELGHVFNMPHDDSNKC----KEESGKNQQH 444

  Fly   621 IMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSF 685
            :|:..:..:.:||.||||||.:|::||:.....||.....:......::|||.:|:::.||:|.|
 Frog   445 VMAPTLNFYTNPWMWSKCSRKYVTQFLDTGYGECLLDEPISRTYTLPQQLPGALYNVNKQCELIF 509

  Fly   686 GNDFGYCP-TDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQ 749
            |.....|| ...:|:||||..:.| .::.|.:.:.||||||.|....| |:.|.|:..:    |.
 Frog   510 GPGSQVCPYMQMQCRRLWCISSDG-QHKGCRTQHTPWADGTECEPGKH-CRYGVCIPKE----RD 568

  Fly   750 V---NGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMD 811
            |   :|.||.|:||..||.:||||::.|.||||:|.|:||||||.|.|.|::||||..|.....|
 Frog   569 VQIADGSWGSWSPFGACSRSCGGGIKTSIRECNRPEPKNGGKYCVGRRMKFKSCNTELCAKHKRD 633

  Fly   812 PREQQCYAMNGRNMNIPGVNPDTKWVPKYE----KDACKLFCRMDMKVTYFMLKSMVTDGTSCAV 872
            .||:||...:|::.||.|:.|:.:|||||.    ||.||||||:.....|:.|:..|.|||||..
 Frog   634 FREEQCADFDGKHFNINGLPPNVRWVPKYSGILMKDRCKLFCRVAGSTAYYQLRDRVVDGTSCGP 698

  Fly   873 DSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLY 937
            |:.|.||.|:||.||||:.|||.|:.||||||.|.|.:|..:.|...:.: .|.|.         
 Frog   699 DTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTIAGTYNIVH-YGYNS--------- 753

  Fly   938 YVTRIPKGASNIIITQRGY----PDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAG-VTMQYTGS 997
             |.|||.||:|:.:.|..|    .|.|::.|::.....||||.|:.:...:.:..| ..::|:||
 Frog   754 -VVRIPAGATNLDVRQHSYSGKPEDDNYLALSNSHGEFLLNGDFVVSMFKREIKVGNAVIEYSGS 817

  Fly   998 SSVVEQVNTTYSWKLSRDLIVQIISLD--VSPSKRQDTVLLSYSYTI---DKPPDYEAEVEIYRW 1057
            .:.:|::|.|.  ::.:::::||:|:.  .:|..|       |::.|   |||       :.:.|
 Frog   818 DNAIERINCTD--RIEQEIVLQILSVGNLYNPDVR-------YTFNIPIEDKP-------QQFYW 866

  Fly  1058 EMQAP-SNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISE 1121
            ....| ..|:.:|:|...:.|.||..:..:.|:.|.||:...|:.....|||:|.:...|...||
 Frog   867 NPYGPWQPCNKMCQGERKQKPVCIRDSDQLVVSDQRCDRIPQPEPVTEPCNTECEVRWHVARKSE 931

  Fly  1122 CSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGC----WVLSEWSTCS 1182
            |:..|| ||.|.....|.:......::..||..||.........|:|...|    |..|.||.||
 Frog   932 CTVQCG-LGYRTLDIHCAKYTRADGKNEKVDERYCSHLQKPLTKEKCSGDCNTGGWRYSPWSECS 995

  Fly  1183 KSCGTGSQQREAHCY--LH---------------------------------------------- 1199
            ||||||:::|.|.|.  ||                                              
 Frog   996 KSCGTGTRRRRAICVNALHDILDDSKCGQQEKPTEQRCSEFPCPQWKTGDWSDCLVTCGKGHKHR 1060

  Fly  1200 -------NSRVSDDLCNPRTKPH---------------------------------LNTLIGI-- 1222
                   :.|:.|..|:..|||.                                 :..::|.  
 Frog  1061 QTWCQFGDDRLHDRFCDTETKPESVEACEQPECASWQVGPWGQCTAACGPGYQMRVVKCVVGAYR 1125

  Fly  1223 -------CNTESCPTYTKSPNALAV-------------SNWVIGEWGECNEWCEK---TRSVSCS 1264
                   ||..:.||.|:...|.|.             :.|..|.|..|:..|.|   .|.|||.
 Frog  1126 AVVDDSECNAATRPTDTQDCEADACPGIPETKQIVHSRTQWRFGSWTPCSATCGKGTRMRYVSCR 1190

  Fly  1265 HPYG-----IGCGS-RKPKDVRKC----CHIKYTSDWTDCSVQCGEGVKRKKQSC---------- 1309
            ...|     ..|.. .||.....|    |......:|:.|||.||:|...::..|          
 Frog  1191 DDQGSVADEAACAQLPKPLATEACSVTPCGQWKALEWSSCSVTCGQGKATRQVICVDFADQTVDG 1255

  Fly  1310 TRVYKPDVPGTRKR-----RVYVDESY---------------------CISRKVHRP------KL 1342
            :.....|||...:.     ..|::..|                     .::|...||      :.
 Frog  1256 SECDPDDVPAVEQECSMSPCYYLNHDYSKPIQTVPNTDHRIRSNPTLAILNRNTGRPAGSGGSQW 1320

  Fly  1343 RT-----TTKSC------RI------------NC------------------KWNASDWRRCPAD 1366
            ||     .:.:|      |:            ||                  :|...:|..|...
 Frog  1321 RTGPWGACSSTCAGGFQRRVVVCQDENGYPASNCDEKTKPIEQRSCESGSCPQWAFGNWGECSKK 1385

  Fly  1367 CSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICN--------------------------- 1404
            |....:||.|.|:...||...|..|:...:|..|..||                           
 Frog  1386 CGGGTRTRQVVCQRSNGDIFNDLSCEILDKPPDREQCNMHSCPRETGWNSGPWNVCSVSCGRGVK 1450

  Fly  1405 ----NCVRRQSRVISQCNCE---------------------------------GVEKRRDFC--- 1429
                .||.::...:...||:                                 |:::|...|   
 Frog  1451 TRPVYCVTKEGVTVEPENCKHLAKPNIQKKCRGGKCPKWKAGEWEKCSVTCGRGIQQRAVHCQVG 1515

  Fly  1430 FNSHKGRIACPTRAR-------------------VERHSCT----------------------PP 1453
            .........||..||                   .|...|:                      |.
 Frog  1516 AQKMSRESECPQHARPPSEQYCQVAECPLYTWKAEEWQECSKTCDEGLRYRKAICLDEDKKEVPQ 1580

  Fly  1454 PHCRRR-----------------------------------------SAIGSS------------ 1465
            .||...                                         |.:.|:            
 Frog  1581 SHCEENKKPPEVEKCNVQSCEFLWITGEWSECSVTCGTGYKQRLVTCSEVYSAKDHYEYGYQSSA 1645

  Fly  1466 -------------------ISSRPR-----------GTGVSSSRSLNSIG--------------- 1485
                               ||:..|           |:|| :.||:..:.               
 Frog  1646 NCPGEQPPTVQNCYQGECPISASWRVGNWGKCSVTCGSGV-TQRSVQCLTNEDLPSNMCSVDQKP 1709

  Fly  1486 -------GSRNRGTPRSCADLKEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVNV--DPQ 1541
                   .:.:...||:|.::|.:.....||.:.:.::.:::.|||.||.|.:|:||:.:  ...
 Frog  1710 EEKRICYSNHDCDLPRNCLEVKRLKHVGADGEHYVMIQEKIIKIYCAGMQSESPKEYITLLSGEA 1774

  Fly  1542 ENYSIYYEYRTKQTNSCPPESRGHEYYNDQN------------SGRTHFRKLRLNITDLRIMDND 1594
            ||||..|.||.:....||        ||...            :|.:.|.|:||::..|:|:..|
 Frog  1775 ENYSEVYGYRLQNPTECP--------YNGSRREDCQCKKDYTAAGFSTFSKVRLDVVTLQIITTD 1831

  Fly  1595 FKFADSR-GLAQKLGSAGDCYNRIGQCPQGDFSINMKDTDFSIRPGTVWRMHGQYSVMKRISEFD 1658
            ..||.:: |......:|||||: ..:||||.||||:..|..||.....|...|.|:|.: |.:..
 Frog  1832 LHFARTQDGRPVPFATAGDCYS-AAKCPQGRFSINLLGTGLSISETAKWMSQGNYAVTE-IKKSP 1894

  Fly  1659 TTTQMRRGFCGGYCGGCYIAPDSGLYLDVL 1688
            ..|:: .|.||||||.|..:..:||.:.||
 Frog  1895 DGTKV-TGRCGGYCGKCVPSSATGLGVHVL 1923

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 26/124 (21%)
ZnMc_ADAMTS_like 455..655 CDD:239801 90/215 (42%)
Reprolysin 457..655 CDD:279729 89/211 (42%)
Salp15 <696..745 CDD:288931 18/48 (38%)
TSP1 754..806 CDD:214559 31/51 (61%)
ADAM_spacer1 937..1042 CDD:283607 30/111 (27%)
TSP1 1172..1229 CDD:214559 27/157 (17%)
GON 1495..1687 CDD:285848 67/206 (33%)
adamts9NP_001361725.1 Pep_M12B_propep 44..192 CDD:366707 41/181 (23%)
ZnMc_ADAMTS_like 274..480 CDD:239801 90/214 (42%)
ADAM_CR_2 495..563 CDD:375321 27/69 (39%)
TSP1 576..627 CDD:214559 31/50 (62%)
ADAM_spacer1 738..856 CDD:368694 33/137 (24%)
TSP1 986..1039 CDD:214559 17/52 (33%)
TSP1 1041..1093 CDD:214559 6/51 (12%)
TSP1 1096..1151 CDD:214559 8/54 (15%)
TSP1 1166..1219 CDD:214559 15/52 (29%)
TSP1 1219..1275 CDD:214559 12/55 (22%)
TSP1 1320..1372 CDD:214559 6/51 (12%)
TSP1 1374..1428 CDD:214559 16/53 (30%)
PTZ00441 <1467..>1531 CDD:240420 8/63 (13%)
TSP1 1550..1601 CDD:214559 5/50 (10%)
TSP1 1604..1664 CDD:214559 2/59 (3%)
GON 1726..1922 CDD:370060 67/206 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 123 1.000 Domainoid score I5505
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 607 1.000 Inparanoid score I917
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 1 1.000 - - FOG0004456
OrthoInspector 1 1.000 - - otm49234
Panther 1 1.100 - - O PTHR13723
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3160
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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