DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and Ppn

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_788752.2	Gene:	Ppn / 43872	FlyBaseID:	FBgn0003137	Length:	2898	Species:	Drosophila melanogaster

Alignment Length:	818	Identity:	205/818 - (25%)
Similarity:	328/818 - (40%)	Gaps:	136/818 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 WGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCY 818
            |.||:..:.||.||||||....|||.:. .:.|...|:|..::|.||||..||....|.|.|||.
  Fly    60 WTPWSSPSDCSRTCGGGVSYQTRECLRR-DDRGEAVCSGGSRRYFSCNTQDCPEEESDFRAQQCS 123

  Fly   819 AMNGRNMNIPGVNPDTKWVPKYEK--DACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNG 881
            ..:.:..:  ||  ..:||| |..  :.|:|.|....:..|:..:..|.|||.|.....|.||||
  Fly   124 RFDRQQFD--GV--FYEWVP-YTNAPNPCELNCMPKGERFYYRQREKVVDGTRCNDKDLDVCVNG 183

  Fly   882 ICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLL-GLNDGNEPNKTLYYVTRIPKG 945
            .|.|.|||..|.|.||.|||..|.|...||..:...:...:|. |.||          :..:|:|
  Fly   184 ECMPVGCDMMLGSDAKEDKCRKCGGDGSTCKTIRNTITTKDLAPGYND----------LLLLPEG 238

  Fly   946 ASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSS---SVVEQVNTT 1007
            |:||.| :...|..|::...:...:..|||.:...:|....:|.....|....   :..:|:  |
  Fly   239 ATNIRI-EETVPSSNYLACRNHSGHYYLNGDWRIDFPRPMFFANSWWNYQRKPMGFAAPDQL--T 300

  Fly  1008 YSWKLSRDL-IVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEG 1071
            .|..:|..| ||.::        ::..:.|.|.|:|.:...: ::.:.:.|.....:.|.:.|.|
  Fly   301 CSGPISESLFIVMLV--------QEKNISLDYEYSIPESLSH-SQQDTHTWTHHQFNACSASCGG 356

  Fly  1072 RSH-RLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGELGTREK 1134
            .|. |...|.:.....:|.|..||:.:.| ::::||.|: |..:......|:||..||..|.:.:
  Fly   357 GSQSRKVTCNNRITLAEVNPSLCDQKSKP-VEEQACGTEPCAPHWVEGEWSKCSKGCGSDGFQNR 420

  Fly  1135 TYACVQTFTNMQRSNIVDMSYC--KLKFDVAYHEECR---EGC--WVLSEWSTCSKSCGTGSQQR 1192
            :..| :..::.....:.:.:.|  ::....|..:||.   :.|  :.|..|:.|.|.||.|.|.|
  Fly   421 SITC-ERISSSGEHTVEEDAVCLKEVGNKPATKQECNRDVKNCPKYHLGPWTPCDKLCGDGKQTR 484

  Fly  1193 EAHCYL----HNSRVSDDLC---NPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGE 1250
            :..|::    |...:.::.|   .|.|:..       |....|...          :|:|.:|..
  Fly   485 KVTCFIEENGHKRVLPEEDCVEEKPETEKS-------CLLTPCEGV----------DWIISQWSG 532

  Fly  1251 CNEWC---EKTRSVSCSHPYG-----IGCGSRKPKDVRKC----CHIK-YTSDWTDCSVQCGEGV 1302
            ||. |   .:||:..|.:..|     ..|....|...|.|    |..: ::|:|:.||..||:||
  Fly   533 CNA-CGQNTETRTAICGNKEGKVYPEEFCEPEVPTLSRPCKSPKCEAQWFSSEWSKCSAPCGKGV 596

  Fly  1303 KRKKQSCTRV-YKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINC--KWNASDWRRCP 1364
            |.:...|... .|...|..       |:|.|  .|..:|:.....:.....|  :|....|.:|.
  Fly   597 KSRIVICGEFDGKTVTPAD-------DDSKC--NKETKPESEQDCEGEEKVCPGEWFTGPWGKCS 652

  Fly  1365 ADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRVI-------------SQ 1416
            ..|....:.|:|.|.|   :|.:..:||.:|.......||:....:..::             ..
  Fly   653 KPCGGGERVREVLCLS---NGTKSVNCDEEKVEPLSEKCNSEACTEDEILPLTSTDKPIEDDEED 714

  Fly  1417 CNCEGVEKRRDFCFNSHK--------GRIACPTRARVE--RHSCTPPPHCR-------------- 1457
            |:.:|:|...|...:..|        |.....|....|  ..|.:|.|:..
  Fly   715 CDEDGIELISDGLSDDEKSEDVIDLEGTAKTETTPEAEDLMQSDSPTPYDEFESTGTTFEGSGYD 779

  Fly  1458 RRSAIGSSISSRPRGTGVSSSRSLNSIGGSRNRGTPRS 1495
            ..|...|.||:...|....:|.:...:..|.:.|:..|
  Fly   780 SESTTDSGISTEGSGDDEETSEASTDLSSSTDSGSTSS 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	22/51 (43%)
		ADAM_spacer1	937..1042	CDD:283607	24/108 (22%)
		TSP1	1172..1229	CDD:214559	16/65 (25%)
		GON	1495..1687	CDD:285848	1/1 (100%)
Ppn	NP_788752.2	TSP1	60..111	CDD:214559	22/51 (43%)
		ADAM_spacer1	214..329	CDD:283607	28/135 (21%)
		TSP1	468..521	CDD:214559	14/59 (24%)
		TSP_1	645..693	CDD:278517	13/50 (26%)
		Kunitz_BPTI	1611..1663	CDD:278443
		Kunitz_BPTI	1670..1721	CDD:278443
		Kunitz_BPTI	1729..1781	CDD:278443
		Kunitz_BPTI	1789..1840	CDD:278443
		Kunitz_BPTI	1848..1899	CDD:278443
		KU	1920..1973	CDD:238057
		Kunitz_BPTI	2001..2051	CDD:278443
		KU	2071..2121	CDD:238057
		Kunitz_BPTI	2127..2178	CDD:278443
		KU	2192..2245	CDD:238057
		KU	2251..2304	CDD:238057
		KU	2316..2372	CDD:238057
		WAP	2457..2497	CDD:278522
		Ig	2521..2610	CDD:299845
		IG_like	2530..2610	CDD:214653
		IG_like	2627..2703	CDD:214653
		Ig	2636..2701	CDD:143165
		IG_like	2766..2841	CDD:214653
		Ig	2768..2830	CDD:299845
		PLAC	2851..2883	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456952
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840