Protein Alignment AdamTS-A and stl

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: NP_001097423.1
• Gene: stl / 37619
• FlyBaseID: FBgn0086408
• Length: 1136
• Species: Drosophila melanogaster
• Alignment Length: 1085
• Identity: 225/1085 - (20%)
• Similarity: 377/1085 - (34%)
• Gaps: 325/1085 - (29%)

  Fly   304 QLHLVLRQDASFVHNHSMTHIRILKEGE---EHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVSV 365
            :..|.|:|....: :.:...||..:.|.   || .|:.....|:    |||..       ...::
  Fly   153 EARLQLQQSPQLI-DDAFIFIRRTENGTQFVEH-SPQLLKRLER----CFYRS-------PAAAL 204

  Fly   366 SLC--GGMTGYIKTSFGALLIQPVNRT--SSDEVLH--RVFRK----SQRNARHAVS------KF 414
            .||  |.:.|..:.:...|:|.|:...  :...||:  ||.:.    |:.::|...|      :|
  Fly   205 DLCEPGNVRGVFQQNGSDLVIHPLPARFGTGTHVLYQARVDKSGGGYSEASSRRTASPLDSQLQF 269

  Fly   415 ELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRH----------------------YADVDNQVYTL 457
            |...::|.....:::.:.|.....:|..:.||                      ::|:..::: :
  Fly   270 EPDAEEFNEPRRRLRAQSQLQSPLRLRFQPRHHHPHQHHQQRRRRYIGDAPRSRWSDIPEELF-I 333

  Fly   458 EVLIAVDNSM-----KQFHGEDLQPYILILMSIVSSI---FADASIGNSIRILLVRLISLPNIND 514
            |..|.||:.:     |.|........:..|:::::.:   :...::|..|..:|.||....:.:.
  Fly   334 ETAIFVDSDLYAHMQKNFPTNTESKVVSFLLAMINGVQLLYHHPTLGRRINFVLKRLEIWKSWDP 398

  Fly   515 ----QTHSSNEMLKHFCQ-------FINQSGYERDTAMLITREPICGSVPGKI-CHMLGLAELGT 567
                ::......|..||:       |.:......|.|:::|...:.....||. ..::|:|.:..
  Fly   399 PGLVRSRDVENYLNSFCKWQEKLNPFSDADPLHYDHALVLTGLDLVTYDKGKANSQVVGMATVKG 463

  Fly   568 VCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDD-KCMPYVTRQNNNKVLHIMSSVMGIHM 630
            :|:| .||:|.:.....:.|.:|||:||.|.|.||..: .|.|         .:||||..:|  .
  Fly   464 MCTSIYSCTINEAKHFESVFVVAHEIGHNLGMRHDAKEISCDP---------TMHIMSPKLG--S 517

  Fly   631 HPWSWSKCSRHFVSEFLEKTDKSCL---ETSVGA--HIPYGTERLPGEIYSLDAQCQLSFGNDFG 690
            ...:||||||.::.:||......||   ::..|.  |...|  |||||.::.:.||.|.||.:|.
  Fly   518 GKVTWSKCSRTYLEDFLMDPQAECLFDRDSFAGPWDHTAGG--RLPGERFNANQQCMLRFGKNFM 580

  Fly   691 YCPTD---EECKRLWCNRTSGNSNEQCASSNLPWA-----DGTPCGSSGHWCQRGKCVSNK---- 743
            ...|.   |.|:.|           .|....|||.     :||.||.: .||:.|.|.:..
  Fly   581 QASTQSKMEICRDL-----------HCRQDGLPWTSHPALEGTECGPN-MWCRGGTCEARSSKQG 633

  Fly   744 ---------------------------------HGYGRQVN------GGWGPWTPFTPCSLTC-- 767
                                             |.|....|      ..||.|:..:.|...|
  Fly   634 SYSALKSWPPEHIPEATHEKIIRHEPNRIPPLLHDYNPMDNELPGSPSNWGEWSEPSACESGCLY 698

  Fly   768 ---------GGGVQESRREC-NQPVPENGGKYCTGSRKKYRSCNTHQC---PPGSM-DPREQQCY 818
                     ..|::...|.| |.|      ..|.|..:::.:|||.||   |..:: |...|.|
  Fly   699 GQSRRLLEGSTGLRTLNRSCLNFP------SRCIGRDRRFVTCNTPQCHKVPVQTINDFATQVC- 756

  Fly   819 AMNGRNMNIPGVNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKS---MVTDGTSCAV-----DSF 875
             |..|..: |.:..:.:.:|.....:||:|||.....|    ||   ...|||:|..     :..
  Fly   757 -MQARKSD-PELTGEGQQLPSTLDASCKIFCRTRTNGT----KSRRWTFPDGTTCKAKQHNPEDI 815

  Fly   876 DKCVNGICRPAGCDNELNSIAKLDKCGVCEGRN-----DTCHEVTGNLLVSNLLGLNDGNEPNKT 935
            ..|::|.|....|||..::..|:|. ..||.|:     |:..:.:...............:|.|.
  Fly   816 TYCISGRCERFSCDNSTSNFFKMDS-SFCEARSVRPTRDSSDQESRQQTNRQRYAERQEGKPQKN 879

  Fly   936 LY-------------------------------YVTRIPK-----GASNIIITQRGYPDQNFIVL 964
            .|                               |...||:     .||.|.:.:....:..::..
  Fly   880 HYENEVAKRPSYGQGNHINAPASPYKRRNYHKPYPPEIPRPPPPASASLIALDRSSSSESEWVAH 944

  Fly   965 TDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSK 1029
            .....|.:.:.|.::         |||.:.||..|                  :|:.|..:.|.:
  Fly   945 PGCHSNCMTDSKGVQ---------GVTSRLTGVES------------------IQLCSYRIQPCE 982

  Fly  1030 RQDTVL---------------------LSYSYTIDKPPDYEAEVEI------YRWEMQAPSNCDS 1067
            |..|..                     ...|.:||: ||....|..      ||:         .
  Fly   983 RLQTAAEYAEQTCARYRQKVRGLSGHGAQISASIDE-PDRSCRVGCQDEFIKYRY---------Y 1037

  Fly  1068 LCEGRSHRLPACISTTQGVKVAP---QFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGEL 1129
            |..||:...|      .|.:.:|   ::|......:..|    .|..|:.|..|:       |:|
  Fly  1038 LVNGRNGHFP------PGTRCSPVGKRYCVYGRCLEFGD----DDLPLDKTHISL-------GQL 1085

  Fly  1130 GTREKTYACVQTFTNMQ----RSNIVDMSYCKLKFDVAYHEECRE 1170
            .||.|..:......|:.    :.:..|:|...::|....|....|
  Fly  1086 RTRRKRSSISNDLFNITEIFIKPSHSDISAENIEFTQPIHVSADE 1130

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	20/96 (21%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	53/221 (24%)
		ADAMTS_CR_2	671..740	CDD:465496	24/76 (32%)
		TSP1	754..806	CDD:214559	17/66 (26%)
		ADAMTS_CR_3	815..911	CDD:437068	30/108 (28%)
		TSP1	1172..1229	CDD:214559
		TSP1_ADAMTS	1243..1282	CDD:465950
		TSP1_ADAMTS	1355..1405	CDD:465950
		GON	1493..1687	CDD:462559
stl	NP_001097423.1	ZnMc_ADAMTS_like	331..543	CDD:239801	54/223 (24%)
		ADAMTS_CR_2	561..625	CDD:465496	24/75 (32%)
		TSP1	683..741	CDD:214559	16/63 (25%)