DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Adamts18

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_038953789.1 Gene:Adamts18 / 361412 RGDID:1560118 Length:1253 Species:Rattus norvegicus


Alignment Length:1358 Identity:371/1358 - (27%)
Similarity:562/1358 - (41%) Gaps:337/1358 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 GLDDLDEEEHSAFVMPTKV-YNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIW 290
            ||:|     ...||:|.:| ...|....|:::..||.|      ...||:..             
  Rat    91 GLND-----DYVFVVPVEVDSGGSYISHDILHNRKRRS------AHGASSSV------------- 131

  Fly   291 DPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYV 355
                .|..:.||:.|||.|:..| .:.:|.:..: :.|:|    ..||...|..:.  |.|.|::
  Rat   132 ----HYRFSAFGQDLHLELKPSA-LLSSHFIVQV-LGKDG----ASETREPAVVQQ--CLYQGFI 184

  Fly   356 EDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDE------------VLHRVFRKSQRNAR 408
            .:|..|.|:||.|.|::|.|:|.....||.|:.:..:.:            ||::      |.|.
  Rat   185 RNDSLSSVAVSTCAGLSGLIRTRDNEFLISPLPQLLAQQHNYSLPAGHHPHVLYK------RTAE 243

  Fly   409 HAVSKFELGLDDFMSK--------------LEQVQEEEQK----SKSRKLNRKKRH--------- 446
            ..|.:::    |:.:.              ..|.||.|.:    .|.....|:|::         
  Rat   244 KRVRRYQ----DYPASQRTYPGHSPSHTPPASQSQETEYRHRRWQKQHFCGRRKKYAPKPPAEDA 304

  Fly   447 YADVD---------------NQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMSIVSSIFADASI 495
            |...|               .:...:|.|:..|..|.:.|| :|:..|||.:|::|||:|.|.:|
  Rat   305 YLRFDEYGGAGRPRRSARKSQKGLNVETLVVADAKMVEKHGKDDVTTYILTVMNMVSSLFKDGTI 369

  Fly   496 GNSIRILLVRLISLPN------INDQTHSSNEMLKHFCQF----INQSGYERDTAMLITREPICG 550
            |:.|.|::|.||.|.:      ||   |.:::.|..|||:    :.::|...|.|:|:|...|| 
  Rat   370 GSDINIVVVSLILLEDEPGGLLIN---HHADQSLNSFCQWQSALVGKNGKRHDHAILLTGFDIC- 430

  Fly   551 SVPGKICHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMPYVTRQN 614
            |...:.|..||.|.:..:||. .||:|.:||||..|||:|||.||...|.||.:..  |....:.
  Rat   431 SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMVHDGEGN--PCRKAEG 493

  Fly   615 NNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCL--ETSVGAHIPYGTERLPGEIYSL 677
            |     |||..:..:...:|||.|||.::.:||......||  |........| .::|||:||..
  Rat   494 N-----IMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQTGQYKY-PDKLPGQIYDA 552

  Fly   678 DAQCQLSFGNDFGYCP---TDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKC 739
            |.||:..||.....|.   ..:.||.|||:|.    ..:|.:..:|.|:||.||.| .||::|:|
  Rat   553 DTQCKWQFGAKAKLCSLGVMKDICKSLWCHRV----GHRCETKFMPAAEGTVCGLS-MWCRQGQC 612

  Fly   740 VSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQ 804
            |.......|.::|.|..|:.::.||.||||||:...|.|:.|.|:.|||||.||.:.|:.||.:.
  Rat   613 VRLGDLGPRPIHGQWSAWSKWSECSRTCGGGVKYQERHCSNPKPQYGGKYCPGSSRIYKLCNINP 677

  Fly   805 CPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY-------EKDACKLFCRMDMKVTYFMLKS 862
            |...|:|.|.|||...|.:        |...|:.::       |:|.|||:|:.:....:|.:..
  Rat   678 CHENSLDFRAQQCAEYNNK--------PFRGWLYRWRPYTKVEEEDRCKLYCKAENFEFFFAMSG 734

  Fly   863 MVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLN 927
            .|.|||.|:....|.|::|||.|.|||:||.|.|..|.||||:|.|.||....| |.:|.    :
  Rat   735 KVKDGTPCSPHRNDVCIDGICEPVGCDHELGSKAVSDACGVCKGDNSTCKFYKG-LYLSQ----H 794

  Fly   928 DGNEPNKTLYY-VTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVT 991
            ..||     || |..||.||.:|.| |......:::.:........|.|.:...:|..|.:||.|
  Rat   795 KANE-----YYPVVTIPAGARSIEI-QELELSSSYLAVRSLSQKYYLTGGWNIDWPGDFTFAGTT 853

  Fly   992 MQYTGSSSVVEQV------NTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDY-- 1048
            .:|....:..|::      |.|        |:.:|::...:|.       :::.|.:.|..:.  
  Rat   854 FEYQRPFNRPERLYAPGPTNET--------LVFEILTQGKNPG-------ITWKYALPKVMNVTQ 903

  Fly  1049 -EAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRL 1112
             .|:...:.|. ...|:|...|.|....:.|.....|..:|...||.....|..:.:.||     
  Rat   904 PAAKRHHHTWR-TVQSDCSVTCGGGYISIKAICLRDQNTQVNSSFCSVRTKPATEPKLCN----- 962

  Fly  1113 NLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSE 1177
                                  .::|                       .||        |:..|
  Rat   963 ----------------------AFSC-----------------------PAY--------WLPGE 974

  Fly  1178 WSTCSKSCGTGSQQREAHC-----YLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNA 1237
            ||||||||..|.|.|:..|     :.....|...|| |.:.|   |.:.:||:.:||        
  Rat   975 WSTCSKSCAGGQQSRKIRCVQKKPFQKEEAVLHSLC-PVSTP---TQVQVCNSHACP-------- 1027

  Fly  1238 LAVSNWVIGEWGECNEWC---EKTRSVSCSH------PYGIGCGSRKPKDVRKC----C----HI 1285
               ..|..|.|.:|::.|   .:.|.|.|:.      |..:...|.||:....|    |    .:
  Rat  1028 ---PEWSPGPWSQCSKTCGRGVRRREVLCTSPAAETLPESLCSSSPKPEAQEGCVLGRCPKNNRL 1089

  Fly  1286 KY-TSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSC 1349
            :: .|.||:||..||.||::::..|   .:..:.|   :.:...|..|  |.:.:|.|.......
  Rat  1090 QWIASAWTECSATCGLGVRKREFKC---MEKTLQG---KLMTFPERRC--RNIKKPNLELEETCN 1146

  Fly  1350 RINCK-------WNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCV 1407
            |..|.       |.:|.|::|...|....|||.|             ||..:.|||     ::|:
  Rat  1147 RRACPVYSMAAGWYSSPWQQCTVTCGGGVQTRSV-------------HCMQQGRPS-----SSCL 1193

  Fly  1408 RRQS-RVISQCN---CEGVEKRRD-----------------FCFNSHKGRIACPTRAR 1444
            ..|. .|:..||   |...|||.|                 .|.:...|:..|.:.:|
  Rat  1194 LHQKPPVLRACNTNFCPVPEKRDDPSCVDFFSWCRLVPQHGVCNHKFYGKQCCRSCSR 1251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 30/107 (28%)
ZnMc_ADAMTS_like 455..655 CDD:239801 76/211 (36%)
Reprolysin 457..655 CDD:279729 76/209 (36%)
Salp15 <696..745 CDD:288931 19/48 (40%)
TSP1 754..806 CDD:214559 24/51 (47%)
ADAM_spacer1 937..1042 CDD:283607 25/111 (23%)
TSP1 1172..1229 CDD:214559 22/61 (36%)
GON 1495..1687 CDD:285848
Adamts18XP_038953789.1 Pep_M12B_propep 99..238 CDD:396235 41/169 (24%)
ZnMc_ADAMTS_like 328..529 CDD:239801 76/211 (36%)
ADAM_CR_2 546..613 CDD:407643 27/71 (38%)
TSP1 627..679 CDD:214559 24/51 (47%)
ADAM_spacer1 784..896 CDD:368694 30/137 (22%)
TSP1_ADAMTS 918..966 CDD:408800 12/74 (16%)
TSP1_ADAMTS 970..1026 CDD:408800 22/59 (37%)
TSP1_ADAMTS 1030..1083 CDD:408800 13/52 (25%)
TSP1_ADAMTS 1091..1150 CDD:408800 17/66 (26%)
TSP1_ADAMTS 1159..1205 CDD:408800 17/63 (27%)
PLAC 1220..1250 CDD:400844 3/29 (10%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100241
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
54.680

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