Protein Alignment AdamTS-A and ADAMTSL5

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_011526263.1
• Gene: ADAMTSL5 / 339366
• HGNCID: 27912
• Length: 485
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 110/388 - (28%)
• Similarity: 167/388 - (43%)
• Gaps: 65/388 - (16%)

  Fly   745 GYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGS 809
            |...|..|.|.||..:|.||.:||.||....|.|.: :|  |.:.|.|...:||.|....||||:
Human    39 GVSAQGPGEWTPWVSWTRCSSSCGRGVSVRSRRCLR-LP--GEEPCWGDSHEYRLCQLPDCPPGA 100

  Fly   810 MDPREQQCYAMNGRNMNIPGVNPDTKWVPKY-EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVD 873
            :..|:.||...|||  .:.|.....:|||.: ..:.|.|.|..:....|... ..|.|||:|:..
Human   101 VPFRDLQCALYNGR--PVLGTQKTYQWVPFHGAPNQCDLNCLAEGHAFYHSF-GRVLDGTACSPG 162

  Fly   874 SFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLL---GLNDGNEPNKT 935
            :...||.|.|..||||..|.|.|..|:||.|.|.||:|      |.|..:.   |...|
Human   163 AQGVCVAGRCLSAGCDGLLGSGALEDRCGRCGGANDSC------LFVQRVFRDAGAFAG------ 215

  Fly   936 LYYVTRIPKGASNIIITQRGYPDQNFIVLT------DDRDNELLNGKFLKTYPLKFVYAGVTMQY 994
            .:.||.||:||.:|.:..|   .:|.:.:.      |.|  .:|||.::.:.|..:..||..:.|
Human   216 YWNVTLIPEGARHIRVEHR---SRNHLGILGSLMGGDGR--YVLNGHWVVSPPGTYEAAGTHVVY 275

  Fly   995 ---TGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI--DKPPDYEAEVEI 1054
               ||....::....|     |.||::|::..:.:|.       :.:.:.:  ::...::|.|:.
Human   276 TRDTGPQETLQAAGPT-----SHDLLLQVLLQEPNPG-------IEFEFWLPRERYSPFQARVQA 328

  Fly  1055 YRWEMQAPSNCDSLCEGRSHRLPA--CISTTQGVKVAPQFCDKSAMPKIDDRA------CNTD 1109
            ..|.::.|..     .|...:.||  .::..|...:||..|  ...|....||      |.:|
Human   329 LGWPLRQPQP-----RGVEPQPPAAPAVTPAQTPTLAPDPC--PPCPDTRGRAHRLLHYCGSD 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254
		ZnMc_ADAMTS_like	455..655	CDD:239801
		ADAMTS_CR_2	671..740	CDD:465496
		TSP1	754..806	CDD:214559	19/51 (37%)
		ADAMTS_CR_3	815..911	CDD:437068	36/96 (38%)
		TSP1	1172..1229	CDD:214559
		TSP1_ADAMTS	1243..1282	CDD:465950
		TSP1_ADAMTS	1355..1405	CDD:465950
		GON	1493..1687	CDD:462559
ADAMTSL5	XP_011526263.1	TSP1	48..97	CDD:214559	19/51 (37%)
		ADAMTS_CR_3	103..200	CDD:437068	37/99 (37%)
		ADAMTS_spacer1	215..315	CDD:461796	27/122 (22%)
		NTR_like	379..480	CDD:239600	2/6 (33%)