DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Adamts3

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_808540.2 Gene:Adamts3 / 330119 MGIID:3045353 Length:1204 Species:Mus musculus


Alignment Length:1463 Identity:355/1463 - (24%)
Similarity:547/1463 - (37%) Gaps:400/1463 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 TSTDHEPPDGLDDLDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTY 282
            ||.|.:.  |.|::.:.:     :|||.|.    |.:|:.....|.. ..:|....||.....:.
Mouse    18 TSADGQA--GTDEMVQID-----LPTKRYR----EYELVTPVSTNLK-GHYLSHILSANHKKRSP 70

  Fly   283 RNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHL 347
            |::|:.  ..|..:|:..|||..||.|:.:..|:...:     :::..|..|.|....:....||
Mouse    71 RDVSSN--SEHLFFNVTAFGRDFHLRLKPNTHFIAPGA-----VVEWHETAPRPGNTTDPRNSHL 128

  Fly   348 ----------------GCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNR-TSSDEV 395
                            .|.|.|.:.|.|.:.|::|.|.|:.|.||:......|:|:.| ...||.
Mouse   129 HGSASEGSWRSEPLQTSCAYVGDIMDIPGTSVAISNCDGLAGMIKSDDEEYFIEPLERGKQMDEE 193

  Fly   396 ---LHRVFRKS---------QRNARHAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYA 448
               :|.|:::|         ..:..|..|..| ||||..:....:.::..|:.     |::||..
Mouse   194 NGRIHVVYKRSAVEQPPRDVSEDVYHRESDLE-GLDDLGTVYSNIGQQLNKTM-----RRRRHTG 252

  Fly   449 DVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNI 512
            :.|   |.:|||:.||:|:.:||| |.:|.|:|.||:||:.|:.|.|:|..|.::|||:|.|...
Mouse   253 END---YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYA 314

  Fly   513 ND----QTHSSNEMLKHFCQFINQS-------GYERDTAMLITRE-----------PICGSVPGK 555
            ..    :..:.:..|::.|::..|.       ....|.|:.:||:           |:.|     
Mouse   315 KSISLIERGNPSRSLENVCRWACQQQKTDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTG----- 374

  Fly   556 ICHMLGLAELGTVCSSSSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDDKCMPYVTRQNNNKVL 619
            :||.:           .||::..:.|..:||.:|||.||:|.|.|| ..::|      .:...:.
Mouse   375 MCHPV-----------RSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRC------GDETAMG 422

  Fly   620 HIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLS 684
            .:|:.::....|.:.||:||...:..::...|  ||......|.......|||..||:|.||:..
Mouse   423 SVMAPLVQAAFHRYHWSRCSGQELKRYIHSYD--CLLDDPFEHDWPKLPELPGINYSMDEQCRFD 485

  Fly   685 FGNDFGYCP---TDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGY 746
            ||..:..|.   |.:.||:|||:..  ::...|.:...|..|||.| ::|.||.:|.|:. |:..
Mouse   486 FGVGYKMCTAFRTFDPCKQLWCSHP--DNPYFCKTKKGPPLDGTEC-AAGKWCYKGHCMW-KNAN 546

  Fly   747 GRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMD 811
            .::.:|.||.||.|..||.|||.||:...|:||.|.|.|||:.|.|...:|:.|||.:|.....|
Mouse   547 QQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFED 611

  Fly   812 PREQQCYAMNGRNMNIPGVNPDTKWVPKYEKDA---CKLFCRMDMKVTYFMLKSMVTDGTSCAV- 872
            .|.|||   ..||.:....|....|:|....|:   |.|:|:.........:|.:|.|||.|:. 
Mouse   612 FRAQQC---QQRNSHFDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYK 673

  Fly   873 DSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL-VSNLLGLNDGNEPNKTL 936
            |.:..||.|.|...|||.|:.|....||||||.|.|..|..|.|... ....||...|       
Mouse   674 DPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRG------- 731

  Fly   937 YYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVV 1001
            .:|  :||||.||.:.:.........:......:.:||||..:.....|:..||...|    ::.
Mouse   732 AFV--LPKGARNISLAETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDY----NIE 790

  Fly  1002 EQVNTTYS-WKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI--DKPPD------YEAEVEIYRW 1057
            :.:.|.:: ..|...:||.||     |.:......|:|.|.|  |..|.      .:.|::.:.|
Mouse   791 DDIETLHTDGPLHDPVIVLII-----PQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEW 850

  Fly  1058 EMQAPSNCDSLCEGR-SHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISE 1121
            .:::.|.|...|.|. .:....|...:....|...||:.:..||...|.||.             
Mouse   851 ALKSWSQCSEPCGGGFQYTKYGCRRKSDSKMVHRSFCEVNKKPKPIRRMCNI------------- 902

  Fly  1122 CSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCG 1186
                                                        :||....|...||..||:|||
Mouse   903 --------------------------------------------QECTHPVWAADEWEHCSRSCG 923

  Fly  1187 TGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGEC 1251
            :...|                                                            
Mouse   924 SSGNQ------------------------------------------------------------ 928

  Fly  1252 NEWCEKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKPD 1316
                  .|:|.|..|                     ..|.|:.||.                   
Mouse   929 ------LRTVRCLQP---------------------LQDGTNRSVH------------------- 947

  Fly  1317 VPGTRKRRVYVDESYCISRKVHRPKLRTTTKSC-RINC--KWNASDWRRCPADCSEEYQTRDVRC 1378
                        ..||:.   .||:.|   :.| |:.|  :|....|..|...|.|..:.|.|.|
Mouse   948 ------------SKYCLG---DRPESR---RPCNRVPCPAQWKTGSWNECSVTCGEGTEVRQVLC 994

  Fly  1379 ESFQGDGVEDKHCDAKK----RPSKRRICNN--CVRRQSRVISQCNCEGVEKRRDFCFNSHKGRI 1437
            .:  ||     |||.:|    ||.:...||:  |:..:|..   |..|.:.:   :|......::
Mouse   995 RT--GD-----HCDGEKPESVRPCQLPPCNDEPCLGDKSIF---CQMEVLAR---YCSIPGYNKL 1046

  Fly  1438 ACPTRARVERHSCTPPPHCRRRSAIGSSI----SSRPR-------------GTGVSSSRSLNSIG 1485
            .|.:.::  |....|||:.:..:.|.|..    |..||             ||. :..:||:|..
Mouse  1047 CCESCSK--RSGTLPPPYLQEAAEIHSDAIFGPSDLPRSLVMPTPFLPSSSGTR-AEKKSLSSFS 1108

  Fly  1486 GSRN-------RGTPRSCADL--KEMHGYNKDGNYQLEVRSRMVHIYCHGMNSRTP--------- 1532
            ...|       |.:.|:.||.  |..|   :.|...||.......|....:...:|         
Mouse  1109 SMANPNADAAFRASSRASADFPRKRAH---QAGRKTLESVPSSSSIKTDHLRPASPVAAAPSPAI 1170

  Fly  1533 QEYVNVDPQENYSIYYEYRTKQTNSCPPESRGH 1565
            .:.:...||.        ||.:.:.....||.|
Mouse  1171 SDSIGASPQT--------RTPKKDDAKSVSRRH 1195

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 30/124 (24%)
ZnMc_ADAMTS_like 455..655 CDD:239801 61/223 (27%)
Reprolysin 457..655 CDD:279729 60/221 (27%)
Salp15 <696..745 CDD:288931 17/48 (35%)
TSP1 754..806 CDD:214559 26/51 (51%)
ADAM_spacer1 937..1042 CDD:283607 25/105 (24%)
TSP1 1172..1229 CDD:214559 9/56 (16%)
GON 1495..1687 CDD:285848 16/82 (20%)
Adamts3NP_808540.2 Pep_M12B_propep 66..200 CDD:279848 34/140 (24%)
ZnMc_ADAMTS_like 256..457 CDD:239801 62/224 (28%)
Reprolysin 258..460 CDD:279729 62/225 (28%)
TSP1 554..605 CDD:214559 26/50 (52%)
ADAM_spacer1 713..828 CDD:283607 30/132 (23%)
TSP1 914..968 CDD:214559 23/177 (13%)
TSP1 971..1016 CDD:214559 16/51 (31%)
PLAC 1024..1052 CDD:285849 5/33 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.870

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