Protein Alignment AdamTS-A and Adamts7

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: NP_001040566.1
• Gene: Adamts7 / 315879
• RGDID: 1306713
• Length: 1808
• Species: Rattus norvegicus
• Alignment Length: 1946
• Identity: 450/1946 - (23%)
• Similarity: 659/1946 - (33%)
• Gaps: 656/1946 - (33%)

  Fly    64 SFACSSSCVSSACSATASDDDEDERALERCLRGTTDDLG-ESGLRYSLKGPPPELYSAKKD---- 123
            |.:||..|  ..|......:|...|:..:  |...||.| |...|...||...:..|..|:
  Rat    62 SLSCSCHC--QRCQRWREREDGTRRSQGQ--REKKDDKGLEKPKRKVQKGKQMQKASGDKESENS 122

  Fly   124 FISKGPLLGRQLEVKKRCEW--WCHKYIQKMSTHWRQNACLYACCIAFLLGMLIMFHLGLRSAHK 186
            ...|.||  ..||..:...|  :.||     |....:.:||.:.....|.|..:.|       .:
  Rat   123 ISRKKPL--PSLEGPRPLSWVDFGHK-----SRSPPRRSCLLSVPSRSLAGFQVSF-------SE 173

  Fly   187 GQEELPQSTHPLANSPPATPATLHPRRLDNDTS--TDHEPPDGLDDLDEEEHSAFVMPTKVYNYS 249
            ||..       .|..|..:...:..::|.|..|  ...|..|||..|..:..|..:...:    |
  Rat   174 GQAF-------FAWDPETSETQIGDKKLQNSRSFGGTSEGTDGLGLLHRQGTSVALQAVQ----S 227

  Fly   250 LS-----EADLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQ-------------- 295
            ||     ...|..|.:...||...::..|.     |::  :|.|:|   |:
  Rat   228 LSCRVGTVLRLPTEGRAGLDIVHPVRVDAG-----GSF--LSYELW---PRVLRKRDVSAAQASS 282

  Fly   296 --YNLNVFGRQLHLVLRQD-----ASFV------HNHSMTHIRILKEGEEHPGPETEAEAEQRHL 347
              |.|...||:|...|..:     ..||      .|.|..||            :|....
  Rat   283 AFYQLQYQGRELLFNLTTNPYLLAPGFVSEIRRRSNLSNVHI------------QTSVPT----- 330

  Fly   348 GCFYSGYVEDDPH---SMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEV--------LHRVFR 401
             |...|.|: ||.   ...::|.|.|:.|..:.|.....|:|:     |||        .|.|:
  Rat   331 -CHLLGDVQ-DPELEGGFAAISACDGLRGVFQLSNEDYFIEPL-----DEVPAQPGHAQPHMVY- 387

  Fly   402 KSQRNARHAVSKFE-----LGLDDFMSKLEQVQEEEQKSK-SRKLNRKKRHYADVDNQVYTLEVL 460
            |.:|:.:...|:..     .|..:...:.|..::.:||.: .|.::::|           .:|.|
  Rat   388 KHKRSGQQDDSRTSGTCGVQGSPELKHQREHWEQRQQKRRQQRSISKEK-----------WVETL 441

  Fly   461 IAVDNSMKQFHGE-DLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ---THSSNE 521
            :..|:.|.::||: .::.|:|.:|::|:.::.|.||||.|.|.:||||.|.:....   ||.:::
  Rat   442 VVADSKMVEYHGQPQVESYVLTIMNMVAGLYHDPSIGNPIHITVVRLIILEDEEKDLKITHHADD 506

  Fly   522 MLKHFCQF---INQSG----YERDTAMLITREPICGSVPGKICHMLGLAELGTVCSSS-SCSIVQ 578
            .||:||::   :|..|    ...|||:|:||:.:|.:: ...|..|||:.:..:|... |||:.:
  Rat   507 TLKNFCRWQKNVNMKGDDHPQHHDTAILLTRKDLCATM-NHPCETLGLSHVAGLCHPQLSCSVSE 570

  Fly   579 DTGLPTAFTMAHELGHILNMNHD-DDDKCMPYVTRQNNNKVLHIMSSVM----GIHMHPWSWSKC 638
            |||||.|||:||||||...:.|| ..:.|      ::..|...|||..:    ||   |.:||:|
  Rat   571 DTGLPLAFTVAHELGHSFGIQHDGTGNDC------ESIGKRPFIMSPQLLYDRGI---PLTWSRC 626

  Fly   639 SRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYC-PTDEECKRLW 702
            ||.:::.||::....||:......:......|||.:|.::.||:|.:|....|| ..|..|..||
  Rat   627 SREYITRFLDRGWGLCLDDRPSKGVINFPSVLPGVLYDVNHQCRLQYGPSSAYCEDVDNVCYTLW 691

  Fly   703 CN-RTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQ-VNGGWGPWTPFTPCSL 765
            |: .|:.:|....|      .|||.||.: .||..|:||  ..|:..: |:|||..|:.::.||.
  Rat   692 CSVGTTCHSKMDAA------VDGTSCGKN-KWCLNGECV--PEGFQPETVDGGWSGWSAWSVCSR 747

  Fly   766 TCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGV 830
            :||.||:.|.|:|.||||:|.||||.|.||:||.||...|||.....|..||...:  :|...|
  Rat   748 SCGVGVRSSERQCTQPVPKNKGKYCVGERKRYRLCNLQACPPDRPSFRHTQCSQFD--SMLYKG- 809

  Fly   831 NPDTKWVPKY-EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVD--SFDKCVNGICRPAGCDNEL 892
             ...||||.. :::.|:|.||.........|:..|.|||.|...  |.|.|::|||:..|||.||
  Rat   810 -KLHKWVPVLNDENPCELHCRPFNYSNREKLRDAVMDGTPCYQGRISRDICIDGICKKVGCDFEL 873

  Fly   893 NSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYP 957
            :|.|:.|:||||.|...|||.|:.....:..:|..|          |..||.||..|:|.:.. .
  Rat   874 DSGAEEDRCGVCRGDGSTCHTVSRTFKEAEGMGYVD----------VGLIPAGAREILIEEVA-E 927

  Fly   958 DQNFIVL-TDDRDNELLNGKFLKTYPLKFVYAGVTMQYT--GSSSVVEQVNTTYSWKLSRDLIVQ 1019
            ..||:.| ::|.|...|||.:...:...:..||.|..||  |:...:.....|     :..:.:|
  Rat   928 AANFLALRSEDPDKYFLNGGWTIQWNGDYQVAGTTFTYTRKGNWETLTSPGPT-----TEPVWIQ 987

  Fly  1020 IISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLC-EGRSHRLPACISTT 1083
            ::..:.:|.       :.|.|||.:....||:...:.|.....|.|...| .|...:...|:...
  Rat   988 LLFQERNPG-------VHYKYTIQRASHSEAQPPEFSWHYGPWSKCPVTCGTGVQRQSLYCMEKQ 1045

  Fly  1084 QGVKVAPQFCDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQR 1147
            .|: |....||..:.|:...|.||.: |.....|.....||.:||..|...:...|.:: ..:..
  Rat  1046 AGI-VDEGHCDHLSRPRDRKRKCNEEPCPARWWVGDWQPCSRSCGPGGFFRRAVFCTRS-VGLDE 1108

  Fly  1148 SNIVDMSYC-----KLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQR--------------- 1192
            ...::.|.|     .|.....||.......|.:..||.||.:||.|.:||
  Rat  1109 QRALEPSACGHLPRPLAEIPCYHYVACPSSWGVGNWSQCSVTCGAGIRQRSVLCINNTGVPCDGA 1173

  Fly  1193 -----EAHCYLH---------------NSRVSDDLCN----------PR---------------- 1211
                 |..|:|.               :...|.:|.|          ||
  Rat  1174 ERPITETFCFLQPCQYSTYIVDTGASGSGSSSPELFNEVDFDPHQPVPRPSPASSPKPVSISNAI 1238

  Fly  1212 --------------------------------------------------TKPHL---------- 1216
                                                              ..||:
  Rat  1239 DEEDPELDPPGPVFVDDFYYDYNFINFHEDLSYGSFEESHSDLVDIGGQTVPPHIRPTEPPSDSP 1303

  Fly  1217 ----------------------------------------NTLIGICNTESCP------------ 1229
                                                    |.|......|..|
  Rat  1304 VPTAGAPGAEEEGIQGSWSPSPLLSEASHSPPVLLENTPVNPLANFLTEEESPIGAPELGLPSVS 1368

  Fly  1230 --------------------------TYTK----------------------------------- 1233
                                      |.::
  Rat  1369 WPPASVDGMVTSVAPGNPDELLVREDTQSQPSTPWSDRNKLSKDGNPLGPTSPALPKSPFPTQPS 1433

  Fly  1234 -----------SPNALAVS---------------------------------------------- 1241
                       ||:|:.||
  Rat  1434 SPSNSTTQASLSPDAVEVSTGWNVALDPVLEADLKPVHAPTDPGLLDQIQTPHTEGTQSPGLLPR 1498

  Fly  1242 -------------------------------------NWVIGEWGECNEWC---EKTRSVSCSHP 1266
                                                 :|.:|.|.:|:..|   ...|.|.||..
  Rat  1499 PAQETQTNSSKDPAVQPLQPSLVEDGAPTDLLPAKNASWQVGNWSQCSTTCGLGAIWRLVRCSSG 1563

  Fly  1267 YGIGCG-SRKPKDVRKC----CHIKYTSDWTDCSVQCGEGVKRKKQSC--TRVYKP-----DVPG 1319
            ....|. |.:|:..|.|    |......:|:.||..||.|...:...|  ||..:|     ..||
  Rat  1564 NDEDCTLSSRPQPARHCHLRPCAAWRAGNWSKCSRNCGGGSATRDVQCVDTRDLRPLRPFHCQPG 1628

  Fly  1320 TRKRRVYVDESYCISRKVHRPKLRTT--TKSCRINCKWNASDWRRCPADCSEEYQTRDVRCESFQ 1382
            ..|                 |..|..  |:.|   ..|..|.||.|...|....|.|.|.|.
  Rat  1629 PTK-----------------PPTRQLCGTQPC---LPWYTSSWRECSEACGGGEQQRLVTCP--- 1670

  Fly  1383 GDGVEDKHCDAKKRPSKRRICNN--CVRRQSRVISQCNCE---GVEKRRDFCFNSHKGRIACPTR 1442
                |...|:...||:..|.||.  |.:.......||:..   ||::|...|.|:..|  .....
  Rat  1671 ----EPGLCEESLRPNNTRPCNTHPCTQWVVGPWGQCSAPCGGGVQRRLVKCVNTQTG--LAEED 1729

  Fly  1443 ARVERHSCTPPPHCRRRSAIGSSISSRPRGTG----VSSSRSLNSIGGSRNRGTPRSCADLKEMH 1503
            :.:..|...|.             ||||..|.    |..||.      .|:|.....|..|:.:
  Rat  1730 SDLCSHEAWPE-------------SSRPCATEDCELVEPSRC------ERDRLPFNFCETLRLL- 1774

  Fly  1504 GYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQENYSIYYEYRTKQTNSCPPESRG 1564
                 |..||..                                  .|.:...||||.|||
  Rat  1775 -----GRCQLPT----------------------------------IRAQCCRSCPPLSRG 1796

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	25/128 (20%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	76/216 (35%)
		ADAMTS_CR_2	671..740	CDD:465496	25/70 (36%)
		TSP1	754..806	CDD:214559	27/51 (53%)
		ADAMTS_CR_3	815..911	CDD:437068	37/98 (38%)
		TSP1	1172..1229	CDD:214559	23/217 (11%)
		TSP1_ADAMTS	1243..1282	CDD:465950	13/42 (31%)
		TSP1_ADAMTS	1355..1405	CDD:465950	16/49 (33%)
		GON	1493..1687	CDD:462559	13/72 (18%)
Adamts7	NP_001040566.1	Pep_M12B_propep	247..387	CDD:460254	37/173 (21%)
		ZnMc_ADAMTS_like	436..644	CDD:239801	78/228 (34%)
		ADAMTS_CR_2	659..723	CDD:465496	25/70 (36%)
		TSP1	736..788	CDD:214559	27/51 (53%)
		ADAMTS_CR_3	794..892	CDD:437068	38/101 (38%)
		ADAMTS_spacer1	894..1003	CDD:461796	29/131 (22%)
		TSP1_ADAMTS	1018..1072	CDD:465950	14/54 (26%)
		TSP1_ADAMTS	1076..1129	CDD:465950	10/53 (19%)
		TSP1_ADAMTS	1139..1187	CDD:465950	13/47 (28%)
		PHA03247	<1216..1525	CDD:223021	14/308 (5%)
		TSP1_ADAMTS	1537..1585	CDD:465950	14/47 (30%)
		TSP1_ADAMTS	1588..1643	CDD:465950	16/71 (23%)
		TSP1_ADAMTS	1646..1692	CDD:465950	17/52 (33%)
		TSP1_ADAMTS	1695..1750	CDD:465950	15/69 (22%)