DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Adamts20

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_038936261.1 Gene:Adamts20 / 315263 RGDID:1307725 Length:1928 Species:Rattus norvegicus


Alignment Length:1915 Identity:493/1915 - (25%)
Similarity:748/1915 - (39%) Gaps:604/1915 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 YESKRNSDINSFLKESASAFAMTGTY--RNMSNEIWDPHP---QYNLNVFGRQLHLVLRQDASFV 316
            ||....:.:|.|    ...|.....:  :..|:.:.:|.|   .|.::.:|:...|.|..|::|:
  Rat    40 YEVVTPTRVNEF----GDVFPQNRHFSRKKRSSGVPEPPPLRTHYRISAYGQLFQLNLSADSAFL 100

  Fly   317 -HNHSMTHIRILKEGEEHPGP--ETEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTS 378
             ..::..|:     |...|||  .:....:.||  |||.|.|......:...|||||:.|..|.:
  Rat   101 AAGYTEVHL-----GTPVPGPGGRSAEPPDLRH--CFYRGQVNAREDHIAVFSLCGGLMGTFKAN 158

  Fly   379 FGALLIQPVNRTSSDE------VLHRVFRKS-QRNA-RHAVSKFELGLDDFMSKLEQVQEEEQKS 435
            .|...::||.:....|      ..|.::|:. :||| ..:.|....|:.:..::...:.....::
  Rat   159 DGEYFLEPVLKADGSEHEDDHNKPHLIYRQEVKRNAFVRSQSHGPCGVSENQTEKTALPSPSFRN 223

  Fly   436 KSRKLNRKKRHYADVDNQVYTL--------------EVLIAVDNSMKQFHGEDLQPYILILMSIV 486
            .:..|||:|.....::.:...|              ||::..|..|.:.||::||.|:|.|||||
  Rat   224 TTGDLNRRKGAVFGLEGERSRLHSRSKRFLSYPRYVEVMVTADAKMVRHHGQNLQHYVLTLMSIV 288

  Fly   487 SSIFADASIGNSIRILLVRLISLPNINDQTHSSNE----------MLKHFCQFINQSGY------ 535
            ::|:.|:||||.|.|::|:|:.:       ||..|          .|::||.:......      
  Rat   289 AAIYKDSSIGNLINIVIVKLVII-------HSEQEGPVISFNAATTLRNFCLWQQSQNVLDDAHP 346

  Fly   536 -ERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNM 598
             ..|||:|||||.|||:  .:.|..||||||||:|. |.||||.::.||..|||:||||||:.|:
  Rat   347 SHHDTAVLITREDICGA--KEKCDTLGLAELGTLCDPSRSCSISEENGLSAAFTIAHELGHVFNV 409

  Fly   599 NHDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHI 663
            .|||..||....|:..    .|:|:..:..|..||:||.||:..::|||:.....||........
  Rat   410 PHDDSFKCKESGTKHQ----YHVMAPTLNYHTSPWTWSACSQKHITEFLDTGHGECLLDKPNGRT 470

  Fly   664 PYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCG 728
            ...:.:|||.:|..:.||:|.||.....||..::|:||||....| .::.|.:.::|.||||.||
  Rat   471 YDLSPQLPGSVYDGNKQCELMFGPGSQVCPYLKQCRRLWCTSAEG-VHKGCRTQHMPLADGTSCG 534

  Fly   729 SSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGS 793
            ...| |.||.||: :....|.|:|.||||.|::.||.|||||::.:.|.|::|.|.|||:||.|.
  Rat   535 PGMH-CHRGLCVT-RDMETRPVDGEWGPWGPYSSCSRTCGGGIRSTARLCDRPEPRNGGRYCVGR 597

  Fly   794 RKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE----KDACKLFCRMDMK 854
            |.|:|||||..||.|..|.||:||...:|::.:|.|:.|:.:|:|||.    ||.|||:||:...
  Rat   598 RMKFRSCNTDSCPKGKRDFREKQCSDFDGKHFDISGLPPNVRWLPKYSGIAVKDRCKLYCRVAGT 662

  Fly   855 VTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL 919
            .:::.||..|.|||.|..::.|.||.|:||.||||:.|||.||.||||||.|.|.:|..:.| :.
  Rat   663 TSFYQLKDRVADGTPCGTETNDICVQGLCRQAGCDHVLNSKAKRDKCGVCGGDNSSCQTLAG-VF 726

  Fly   920 VSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGY----PDQNFIVLTDDRDNELLNGKFLKT 980
            .|...|.|          .|.:||.||:||.|.|..|    .|.|::.|:|.:.|.||||.|:.:
  Rat   727 NSAHYGYN----------VVVKIPAGATNIEILQHSYSGRPEDDNYLALSDTQGNFLLNGNFVVS 781

  Fly   981 YPLKFV-YAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLD--VSPSKRQDTVLLSYSYTI 1042
            ...|.: ..|...:|:||::.:|::|:|.  :|..:|::|::.:.  .:|.       :.|.:.|
  Rat   782 MAKKEINIQGAVFEYSGSNNSIERINSTD--RLEAELVLQVLCVGNLYNPD-------VHYIFNI 837

  Fly  1043 DKPPDYEAEVEIYRWEMQAP-SNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRAC 1106
                ..|....::.|:...| .:|..:|:|...|..|||..:....|:.|.|....:|......|
  Rat   838 ----PIEERSNLFSWDPYGPWQDCTKMCQGLHRRKIACIRKSDRAVVSDQSCSHLPLPLFVTERC 898

  Fly  1107 NTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREG 1171
            ||||.|...:|..|:||:.||: |.|.....|::...:..::..|...||..:......|.|...
  Rat   899 NTDCELRWHITGKSDCSSQCGQ-GYRTLDVHCMKYSVHKGQTVPVGDQYCGDQLKPPNREPCHGS 962

  Fly  1172 C----WVLSEWSTCSKSCGTGSQQREAHC-------------------YLHNSR----------- 1202
            |    |..||||.||:|||.|.:.||::|                   .|.|..           
  Rat   963 CVLTRWHYSEWSQCSRSCGGGEKTRESYCVNGFGHRLAERECQELPRVVLGNCNDFPCPGWATSE 1027

  Fly  1203 -------------------------VSDDLCNPRTKPH--------------------------- 1215
                                     |.||.|:..|||.                           
  Rat  1028 WSECPVTCGKGMKQRQVWCQRSEDPVGDDFCDASTKPESLGPCELRACASWHVGPWGSCTVTCGH 1092

  Fly  1216 -------------LNTLI----------------------------------------------- 1220
                         |.|::                                               
  Rat  1093 GYQVRAVKCVSEILGTVLDDRECPRASRPSDRQDCIFAPCLAILKVGATSLPAIPLGKAAQWRHG 1157

  Fly  1221 -------------------------GI-------------------------------------- 1222
                                     |:                                      
  Rat  1158 SWTPCSVSCGRGSQARYVSCRDAHDGVADELNCAHLPRPAEVSLCFSPCGEWQAGDWSPCSASCG 1222

  Fly  1223 ---------------------------------CNTESC-PTYTKSPNA---------------- 1237
                                             |...:| |:|::||::                
  Rat  1223 HGKTTRRVLCVNYHQLVDESYCDPEGRPVTEQECRLAACPPSYSRSPSSSEQPSHGPGRNVPLTH 1287

  Fly  1238 -----------LAV--------------------------------------------------- 1240
                       |::                                                   
  Rat  1288 KPEENPDQGVQLSIRGNQWRTGPWGACSRSCAGGLQHRAVVCQDEDGRSATSCEATSKPPESKHC 1352

  Fly  1241 -----SNWVIGEWGECNEWC---EKTRSVSCSHPYG-----IGCGSRKPKDVRKCCHIK------ 1286
                 ..|..|:||||.:.|   .|:|.|.|..|.|     ..|...||..:.: ||::      
  Rat  1353 GSGPCPQWNYGDWGECTQTCGAGVKSRFVICQFPDGQMAQEHSCELPKPPSMMQ-CHLRACPDDV 1416

  Fly  1287 --YTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSC 1349
              |...|..||..||:|:|.::..|       :...:::   ::|.||  ..:|:|:   |.|.|
  Rat  1417 SWYRGSWKSCSASCGKGIKYREVLC-------IDQVQRK---LEEKYC--SHLHKPR---THKPC 1466

  Fly  1350 RI-NC-KWNASDWRRCPADCSEEYQTRDVRCESFQGDG-VEDKHCDAKKRPSKRRIC-------- 1403
            |. .| .|.|:.|:.|...|....|.|:|.|. .:|.| |.:..|:...||..:|.|        
  Rat  1467 RSGRCPSWKANKWKECSVTCGSGVQQREVYCR-LRGTGRVAEDMCEPSTRPQVQRPCWHQDCTRY 1530

  Fly  1404 ----------------------NNCVRRQSRVISQCNCEGVEKRRDF--CFNSH----------- 1433
                                  ..||..::..:::..|:.:.|....  |.|||           
  Rat  1531 QWTTGDWLDCSTSCKKKETYRLVKCVNERNMQVNESLCDPLTKPVSIKKCRNSHCKYMVVTGDSS 1595

  Fly  1434 ----------KGRIACPTRAR-------------VERHSC--TPPPH---CRRRSAIGS------ 1464
                      ..||...||.:             |....|  .|.|.   |..||.:..      
  Rat  1596 QCAGNCGLTYSQRITYCTRIQPPKKNAFHHQLRPVNYGQCPVIPSPQVYKCDIRSCLRGATWKVG 1660

  Fly  1465 --SISSRPRGTGVSSSRSLNSIGGSRNRGTP------------------------RSCADLKEMH 1503
              |..|...|.|:...|    :......|.|                        .:|.:::..:
  Rat  1661 KWSKCSVTCGNGIMERR----VACRTENGWPSDLCLKRLKPDAQKKCYANDCKLLTTCKEIQVTN 1721

  Fly  1504 GYNKDGNYQLEVRSRMVHIYCHGMNSRTPQEYVN-VDPQENYSIYYEYRTKQTNSCPPESRGHEY 1567
            ...|||||.|.||.|::.|:|.||....|:||:. |..::|:|..|..|.:....||        
  Rat  1722 NITKDGNYDLNVRGRILKIHCSGMQLENPREYLPLVKVEDNFSEIYGLRLQNPYECP-------- 1778

  Fly  1568 YNDQN------------SGRTHFRKLRLNITDLRIMDNDFKFADSR-GLAQKLGSAGDCYNRIGQ 1619
            :|...            :|.|.|.|:|:::..::|...|..|:.:. |.|....:|||||: ..:
  Rat  1779 FNGSRRADCACENDYPPAGYTVFSKVRVDLASMQIKTTDLLFSRTLFGKAVPFATAGDCYS-AAR 1842

  Fly  1620 CPQGDFSINMKDTDFSIRPGTVWRMHGQYS 1649
            ||||.||||:..|...:.....|...|:|:
  Rat  1843 CPQGQFSINLAGTGMKVSSTAKWLAQGRYA 1872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 31/113 (27%)
ZnMc_ADAMTS_like 455..655 CDD:239801 88/231 (38%)
Reprolysin 457..655 CDD:279729 88/229 (38%)
Salp15 <696..745 CDD:288931 20/48 (42%)
TSP1 754..806 CDD:214559 29/51 (57%)
ADAM_spacer1 937..1042 CDD:283607 33/111 (30%)
TSP1 1172..1229 CDD:214559 29/299 (10%)
GON 1495..1687 CDD:285848 52/169 (31%)
Adamts20XP_038936261.1 Pep_M12B_propep 41..186 CDD:396235 37/155 (24%)
ZnMc_ADAMTS_like 257..463 CDD:239801 88/218 (40%)
ADAM_CR_2 478..545 CDD:407643 28/68 (41%)
TSP1 558..610 CDD:214559 29/51 (57%)
ADAM_spacer1 720..838 CDD:368694 38/141 (27%)
TSP1_ADAMTS 906..959 CDD:408800 13/53 (25%)
TSP1_ADAMTS 968..1020 CDD:408800 16/51 (31%)
TSP1_ADAMTS 1023..1075 CDD:408800 7/51 (14%)
TSP1_ADAMTS 1078..1132 CDD:408800 2/53 (4%)
TSP1_ADAMTS 1154..1206 CDD:408800 1/51 (2%)
TSP1_ADAMTS 1209..1261 CDD:408800 1/51 (2%)
TSP1_ADAMTS 1306..1357 CDD:408800 0/50 (0%)
TSP1_ADAMTS 1360..1412 CDD:408800 18/52 (35%)
TSP1_ADAMTS 1418..1471 CDD:408800 18/67 (27%)
TSP1_ADAMTS 1474..1527 CDD:408800 17/53 (32%)
TSP1_ADAMTS 1532..1585 CDD:408800 7/52 (13%)
TSP1_ADAMTS 1657..1708 CDD:408800 7/54 (13%)
GON 1713..1880 CDD:400843 52/169 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 120 1.000 Domainoid score I5619
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 596 1.000 Inparanoid score I924
OMA 1 1.010 - - QHG48392
OrthoDB 1 1.010 - - D125522at2759
OrthoFinder 1 1.000 - - FOG0004456
OrthoInspector 1 1.000 - - otm46150
orthoMCL 1 0.900 - - OOG6_100241
Panther 1 1.100 - - O PTHR13723
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X3160
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1211.980

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