DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and AdamTS-B

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_572247.2	Gene:	AdamTS-B / 31490	FlyBaseID:	FBgn0029791	Length:	1023	Species:	Drosophila melanogaster

Alignment Length:	1250	Identity:	320/1250 - (25%)
Similarity:	470/1250 - (37%)	Gaps:	373/1250 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 LGMLIMFHL-------------GLRS----AHKGQEELPQSTHPLANSPPATPATLHPRRLDNDT 218
            ||:|:.:.|             ||.|    |.:||..:|:..|
  Fly    13 LGLLLHYWLVVVTQGGGVRPLYGLHSDELVAGEGQLVVPRRVH---------------------- 55

  Fly   219 STDHEPPDGLDDLDEEEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYR 283
                  |||          ||:.....|.:.|       :.:|:....|...|..:..|
  Fly    56 ------PDG----------AFMTHQLEYAHEL-------DHRRHRQRRSLNSEHDTQAA------ 91

  Fly   284 NMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEG---EEHPGP-ETEAEAEQ 344
                                .|||:|......:|...|.|...|...   |.|... .|.:....
  Fly    92 --------------------DLHLLLPLANETLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTT 136

  Fly   345 RHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTSSDEV---LHRVFRKSQRN 406
            |||.|.:.|.|...|.:.|::|.|.|:.|:|:|:.....|:|........|   .|.||::|...
  Fly   137 RHLNCHFHGKVRGQPATNVAISTCAGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVK 201

  Fly   407 ARHAVSK----------------FELGLDDFMSKLEQVQEEEQKSK-----SRKLNR-------- 442
            .:|::.|                ...|..:...::|...|.:.:.|     .|::.|
  Fly   202 PKHSLRKRNKRKRGGKSGSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHH 266

  Fly   443 ----KKRHYAD-----------VDNQVYT-------------------LEVLIAVDNSMKQFHGE 473
                |.||:..           .:.|..|                   :|.||..|.:|..|| .
  Fly   267 HHKHKYRHHQQKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFH-R 330

  Fly   474 DLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNINDQ-----THSSNEMLKHFCQF---I 530
            ||..|:|.:|::||:::.|.||||||.|::||:|.|.....|     |.::.:.|..||.:   :
  Fly   331 DLNGYLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQHKL 395

  Fly   531 NQSG----YERDTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAH 590
            |:..    :..|.|:||||:.||.:    .|..||||.:|.:|. ..|||:.:|.|:..:.|:.|
  Fly   396 NKGSEKDPHHHDVAILITRKNICAN----NCMTLGLANVGGMCKPKQSCSVNEDNGIMLSHTITH 456

  Fly   591 ELGHILNMNHDDDD-KCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSC 654
            ||||...|.||... .|.|.|     ..::|||:...|.......||.|||.:::.||::....|
  Fly   457 ELGHNFGMFHDTAKIGCHPRV-----GPIVHIMTPTFGADTLQVCWSNCSRKYITHFLDQGLGEC 516

  Fly   655 LETSVGAHIPYG-TERLPGEIYSLDAQCQLSFG----NDFGYCPTDEE-CKRLWCNRTSGNSNEQ 713
            |:........|. |..|||..|:...||:|.|.    ::.|.|....| |..|||     ..|.:
  Fly   517 LDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFCSTLWC-----KVNGE 576

  Fly   714 CASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRREC 778
            |.:...|.|.||.||.: .|||.||||..:.  ...||||||.|:.::.||.:|||||...:|||
  Fly   577 CVTHMRPTAPGTLCGRN-KWCQNGKCVRREE--LAAVNGGWGDWSEWSECSRSCGGGVSTQQREC 638

  Fly   779 NQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYEK- 842
            :.|||.|||.:|.|.||:|:.|....||......|.|||...:  |::..|..  .||:|.::|
  Fly   639 DNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFD--NVSYQGAT--YKWLPFFDKN 699

  Fly   843 DACKLFCRMDMKVTYFM-LKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEG 906
            :.||||| .|:..|... ..:.|.|||.|.:.:.:.|::|||:..|||..::|..:.|:||||.|
  Fly   700 NPCKLFC-SDVDDTIIANWGATVLDGTPCTLGTNNMCIDGICKKVGCDWIVDSEVQDDRCGVCGG 763

  Fly   907 RNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLT-DDRDN 970
            ..|.|..|...  .::.....||     ....:..||..|.:|:|.:.........:.| |..|.
  Fly   764 SGDQCQPVRET--YTDPFAAKDG-----AYVEIVTIPARARHILIRELANSPHFLAIATGDGGDR 821

  Fly   971 ELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVL 1035
            ..|||..|.:.|.:|       :..|:.|:.::|:                        .|:|:
  Fly   822 FYLNGDSLISMPGEF-------EIAGAESLYDRVD------------------------EQETI- 854

  Fly  1036 LSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPK 1100
                 ||.:|  .:..:.:|.......||.....|   ..|||
  Fly   855 -----TIPQP--IQHSISLYAIVRGNESNAGIFYE---FTLPA---------------------- 887

  Fly  1101 IDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYH 1165
                       ||:|..
  Fly   888 -----------LNVTAG------------------------------------------------ 893

  Fly  1166 EECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDL-C--NPRTKPHLNTLIGICNTES 1227
               |:..|.||.|:.||.|||.|.|.||..|..:...:.|.| |  :.:.|.......| |..:.
  Fly   894 ---RQFQWRLSNWTACSASCGGGVQHREPICQENGKALGDTLPCWTHAKNKRPARQSRG-CGDQP 954

  Fly  1228 CPTYTKSPNALAVSNWVIGEWGECNEWC---------EKTRSVSCSHPYGI-----GCGS-RKPK 1277
            ||           ::|..|.|..|...|         ::.|||.|...:.:     .||. :||.
  Fly   955 CP-----------AHWWPGPWQFCPVTCRPVGFVAPPQRRRSVVCLDEHDVVVADAECGHLQKPA 1008

  Fly  1278 DVRKC------CHIK 1286
            ::..|      |..|
  Fly  1009 EMEPCESSLPICRTK 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	27/111 (24%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	76/232 (33%)
		Reprolysin	457..655	CDD:279729	75/211 (36%)
		Salp15	<696..745	CDD:288931	20/49 (41%)
		TSP1	754..806	CDD:214559	25/51 (49%)
		ADAM_spacer1	937..1042	CDD:283607	19/105 (18%)
		TSP1	1172..1229	CDD:214559	20/59 (34%)
		GON	1495..1687	CDD:285848
AdamTS-B	NP_572247.2	Pep_M12B_propep	78..194	CDD:279848	32/141 (23%)
		ZnMc_ADAMTS_like	314..518	CDD:239801	76/213 (36%)
		Reprolysin	315..521	CDD:279729	77/215 (36%)
		ADAM_CR	<558..602	CDD:301627	19/49 (39%)
		TSP1	614..666	CDD:214559	25/51 (49%)
		ADAM_spacer1	773..886	CDD:283607	28/161 (17%)
		TSP1	901..956	CDD:214559	18/55 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	P	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.750