DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts10

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_001258374.1	Gene:	Adamts10 / 314655	RGDID:	1598320	Length:	1104	Species:	Rattus norvegicus

Alignment Length:	1082	Identity:	325/1082 - (30%)
Similarity:	467/1082 - (43%)	Gaps:	216/1082 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 AEQRHLGCFYSGYVEDDP-HSMVSVSLCGGMTGYIKTSFGALLIQPV------NRTSSDEVLHRV 399
            |.:.|  |.|:|:::... .|.|::|.|||:.|.|.......||:|:      .|...:...|.|
  Rat   117 AARAH--CLYAGHLQGQAGSSHVAISTCGGLHGLIVADDEEYLIEPLQGGPKGRRGPEESGPHVV 179

  Fly   400 FRKSQRNARHAVSKFELGLDD---------FMSKLE------QVQEEEQKSKSRKLNRKKRHYAD 449
            :::|  :.||.......|:.|         ::..|:      |..|.|:.....|.:..:..|
  Rat   180 YKRS--SLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPQGNETERGQLGLKRSVSRERY-- 240

  Fly   450 VDNQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNIN 513
                   :|.|:..|..|..:|| .|::.|:|.:|:||:.:|.|:|:||.:.||:.|||.|  ..
  Rat   241 -------VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGNIVNILVTRLILL--TE 296

  Fly   514 DQ-----THSSNEMLKHFCQF----INQSGY----------ERDTAMLITREPICGSVPGKICHM 559
            ||     ||.:.:.|..||::    ::.||:          ..|||:||||..|| ....|.|..
  Rat   297 DQPTLEITHHAGKSLDSFCKWQKSIVSHSGHGNAIPENGVANHDTAVLITRYDIC-IYKNKPCGT 360

  Fly   560 LGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHD-----------DDDKCM-PYVT 611
            ||||.:|.:|. ..||||.:|.||.||||:|||:||...||||           |..|.| .::|
  Rat   361 LGLAPVGGMCERERSCSINEDIGLATAFTIAHEIGHTFGMNHDGVGNGCGARGQDPAKLMAAHIT 425

  Fly   612 RQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAH-IPYGTERLPGEIY 675
            .:.|                |:.||.|||.:::.||:.....||....... ..|.|. .||:.|
  Rat   426 MKTN----------------PFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTV-APGQAY 473

  Fly   676 SLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGH-----WCQ 735
            ..|.||:...|.....|...|.|..|||.    :.:.:|.::::|.|:||.|.:  |     ||.
  Rat   474 DADEQCRFQHGVKSRQCKYGEVCSELWCL----SKSNRCITNSIPAAEGTLCQT--HTIDKGWCY 532

  Fly   736 RGKCV---SNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKY 797
            :..||   |...|    |:|.||||||:..||.:|||||..|.|.|:.|.|..|||||.|.|:::
  Rat   533 KRVCVPFGSRPEG----VDGAWGPWTPWGDCSRSCGGGVSSSSRHCDSPRPTIGGKYCLGERRRH 593

  Fly   798 RSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE---KDACKLFCRMDMKVTYFM 859
            |||||:.|||||.|.||.||...:    ::|.......| ..|.   ..||.|.|..|....|..
  Rat   594 RSCNTNDCPPGSQDFREMQCSEFD----SVPFRGKFYTW-KTYRGGGVKACSLTCLADGFNFYTE 653

  Fly   860 LKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLL 924
            ..:.|.|||.|..|:.|.||:|.|:..|||..|.|..:.|||.||.|....|..:.|  :.|..|
  Rat   654 RAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEG--VFSPAL 716

  Fly   925 ---GLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNF----IVLTDDRDNELLNGKFLKTYP 982
               |..|          |..||||:.:|.|     .|.|.    :.|..|:::.||.|....:.|
  Rat   717 PGTGYED----------VVWIPKGSVHIFI-----QDLNLSLSHLALKGDQESLLLEGLPGTSQP 766

  Fly   983 LKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPD 1047
            .:...||.|..........:.:...  ..::..||:.:::....|:.|         |..:.|..
  Rat   767 HRLPLAGTTFHLRQGPDQAQSLEAL--GPINASLIIMVLAQAELPALR---------YRFNAPIA 820

  Fly  1048 YEAEVEIYRWEMQAPSNCDSLCEGRSH-RLPACISTTQGVKVAPQFCD-KSAMPKIDDRACNTD- 1109
            .:| :..|.|.....:.|.:.|.|.|. ::..|.:......|||.:|. .|.:|| ..|||||:
  Rat   821 RDA-LPPYSWHYAPWTKCSAQCAGGSQVQVVECRNQLDSSAVAPHYCSAHSKLPK-RQRACNTEP 883

  Fly  1110 CRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGC-- 1172
            |..:..|.:.|.||.:| :.|.|.::..| |...:......:|.|.|...     .....|.|
  Rat   884 CPPDWVVGNWSRCSRSC-DAGVRSRSVVC-QRRVSAAEEKALDDSACPQP-----RPPVLEACQG 941

  Fly  1173 ------WVLSEWSTCSKSCGTGSQQREAHCYLHNSR--VSDDLCNPRTKPHLNTLIGICNTESCP 1229
                  |...:||.|:.|||.|.:.|...|...:.|  :....|.|..||. :|:  .||...||
  Rat   942 PMCPPEWAALDWSECTPSCGPGLRHRVVLCKSADQRSTLPPGHCPPAAKPP-STM--RCNLRRCP 1003

  Fly  1230 TYTKSPNALAVSNWVIGEWGECNEWC---EKTRSVSCSHPYGIGCGSRKPKDVRKCCHIKYTSDW 1291
            .          :.||..|||||:..|   ::.|:|.|:...|      :|.  |:|......|..
  Rat  1004 P----------ARWVASEWGECSTQCGLGQQQRTVRCTSHTG------QPS--RECTEALRPSTM 1050

  Fly  1292 TDCSVQC------GEGVKR--------------KKQSCTRVY 1313
            ..|..:|      |:|.:.              |.|.|:|.|
  Rat  1051 QQCEAKCDSVVPPGDGPEECKDVNKVAYCPLVLKFQFCSRAY 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	17/58 (29%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	82/232 (35%)
		Reprolysin	457..655	CDD:279729	82/230 (36%)
		Salp15	<696..745	CDD:288931	17/56 (30%)
		TSP1	754..806	CDD:214559	30/51 (59%)
		ADAM_spacer1	937..1042	CDD:283607	23/108 (21%)
		TSP1	1172..1229	CDD:214559	19/66 (29%)
		GON	1495..1687	CDD:285848
Adamts10	NP_001258374.1	Pep_M12B_propep	40..180	CDD:396235	18/64 (28%)
		ZnMc_ADAMTS_like	239..454	CDD:239801	84/242 (35%)
		ADAM_CR_2	469..537	CDD:407643	22/73 (30%)
		TSP1	550..602	CDD:214559	30/51 (59%)
		ADAM_spacer1	706..818	CDD:368694	28/139 (20%)
		TSP1_ADAMTS	829..884	CDD:408800	18/55 (33%)
		TSP1_ADAMTS	888..944	CDD:408800	14/62 (23%)
		TSP1_ADAMTS	948..1002	CDD:408800	18/56 (32%)
		TSP1_ADAMTS	1007..1057	CDD:408800	17/57 (30%)
		PLAC	1070..1102	CDD:400844	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820