DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and Adamtsl5

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_038934914.1	Gene:	Adamtsl5 / 314626	RGDID:	1305607	Length:	714	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	107/427 - (25%)
Similarity:	160/427 - (37%)	Gaps:	120/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 GGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCN----------THQCP 806
            |.|..|..::.||.:||.||...||.|.: :||.  :.|.|...:||.|.          |..||
  Rat   198 GEWTLWGSWSRCSSSCGRGVSVRRRHCVR-LPEE--ELCWGDSHEYRVCQLPFYPSTFMLTQDCP 259

  Fly   807 PGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY-EKDACKLFCRMDMKVTYFMLKSMVTDGTSC 870
            ||::..|:.||...||.  .:.|.....:|||.: ..:.|.|.|..:....|... ..|.|||.|
  Rat   260 PGAIPFRDLQCSLYNGH--PVLGTQKTYQWVPFHGAPNLCDLNCLAEGHAFYHSF-GRVLDGTPC 321

  Fly   871 AVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTC------------------------ 911
            ...:...||.|.|..||||..|.|....|:||:|.|.||:|
  Rat   322 TPGTQGLCVAGRCLSAGCDGLLGSGTLEDRCGLCGGANDSCLFVQRVFRDAGDCPIPPHGLHLRS 386

  Fly   912 -------------------------------HEVTGNLLVSNLLGLNDGNEPNKTLY----YVTR 941
                                           |..|.:.:..||..|:....|....:    .||.
  Rat   387 MVDRGPFNEFGSWEPRLLLIGQCVPVHPTTAHPCTCHRVPENLAALHPKLPPASGAFAGYWNVTL 451

  Fly   942 IPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNT 1006
            ||:||.:|.:|||.:   |.:.|.....:.:|||..:.:.|..:..||..:.||.|:...|.:..
  Rat   452 IPEGARHIRVTQRSH---NHLALVTRDGHYVLNGDGVLSLPGTYEAAGTRVVYTRSAGPEETLQA 513

  Fly  1007 TYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQ----------- 1060
            |  ...|::|::|::..:.:|.     |...:....::...::|:|....|.::
  Rat   514 T--GPTSQELLLQVLLREPNPG-----VHFEFWLPRERYGSFQAQVHALGWPLRQPQPREVEPQP 571

  Fly  1061 -----------------APSNC----DSLCEGRSHRL 1076
                             ||..|    ||  .||:|||
  Rat   572 AETTVVPEAIPARVASLAPDPCGPCPDS--RGRAHRL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	19/61 (31%)
		ADAM_spacer1	937..1042	CDD:283607	28/108 (26%)
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
Adamtsl5	XP_038934914.1	TSP1	200..246	CDD:214559	18/48 (38%)
		ADAM_spacer1	444..541	CDD:368694	28/106 (26%)
		NTR_like	608..707	CDD:239600
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900