Protein Alignment AdamTS-A and Papln

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: XP_038969231.1
• Gene: Papln / 314297
• RGDID: 1311176
• Length: 1328
• Species: Rattus norvegicus
• Alignment Length: 1078
• Identity: 238/1078 - (22%)
• Similarity: 365/1078 - (33%)
• Gaps: 313/1078 - (29%)

  Fly   725 TPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKY 789
            ||    |.|.|.          .|:.:..||.|..::|||.|||||:....|.|... ..:||..
  Rat    69 TP----GSWAQN----------VRRQSDTWGAWGEWSPCSRTCGGGISFRERPCYSQ-RRDGGAS 118

  Fly   790 CTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY-EKDACKLFCRMDM 853
            |.|..:.:|:|:|..||....|.|.:||...:|.:..    ....:|:|.| ..:.|:|.|....
  Rat   119 CVGPARSHRTCHTESCPDSVRDFRAEQCAEFDGTDFQ----GRRYRWLPYYAAPNKCELNCIPKG 179

  Fly   854 KVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNL 918
            :..||..:..|.|||.|.....|.||.|:||..|||::|:|..:.|||..|.|...:|:.:||..
  Rat   180 QNFYFKHRDAVVDGTPCEPGKRDICVEGVCRVVGCDHKLDSTKQEDKCLQCGGDGSSCYPITGTF 244

  Fly   919 LVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPL 983
                     |.|:.::....:..||.||::|.| :.....:||:.:...|....|||.:......
  Rat   245 ---------DANDLSRGYNQIFIIPAGATSIHI-EEADASRNFLAVKSIRGEYYLNGHWTIEEAQ 299

  Fly   984 KFVYAGVTMQY-TGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVL--------LSYS 1039
            ....|...:|| .|....:...........|..|::::|..:.:|....:..|        .|:|
  Rat   300 ALPVASTVLQYERGVEGDLAPERLQARGPTSEPLVIELIIQESNPGVHYEYYLPVNDPGRSFSWS 364

  Fly  1040 Y---------------------TIDKP--PDYEAE----------------VEIYRWEMQAPSNC 1065
            |                     |||..  ||:..:                .:..||::...:.|
  Rat   365 YGSWGDCSAECGGGHQSRLVFCTIDNEAYPDHMCQHQPRPAHRRSCNTHPCPKTKRWKVGPWTPC 429

  Fly  1066 DSLCEGR-SHRLPACIST--TQGVKVAPQF-CDKSAMPKIDDRACNTDCRLNLTVTSISECSAAC 1126
            ...|.|. ..|...|:|:  |.|.:.|.:. |...|......:|||.......:|....|||..|
  Rat   430 SVSCGGGFQSRSVYCVSSDGTGGQEAAEETQCAGLAGKPPTTQACNLQRCAVWSVEPWGECSVTC 494

  Fly  1127 GELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEEC-REGC-------WVLSEWSTCSK 1183
            | .|.|:::..|     .....::|..:.|.||......|.| ||.|       |.:..||.|||
  Rat   495 G-AGIRKRSVTC-----RGDEDSLVHPAACSLKDQPTLTEPCVREACPGFRGQAWHVGSWSLCSK 553

  Fly  1184 SCGTGSQQREAHCYLHNSRVSDDLCNPRTKPHLNTLIGICNTESC------PTYTKS-------- 1234
            |||:|.::|:..|.:.......||  ..:||   ..:..||.:.|      |:...|
  Rat   554 SCGSGIRRRQVVCTIGPPGRCVDL--QSSKP---AEVEACNRQPCHLPQEVPSIQDSRTHPSDRR 613

  Fly  1235 ----PNALAVSNWVIGEW--------------GECNEWCEKTRSVSCSHPYGIGCGSRKP----- 1276
                |....|::....:|              |:.:......|:.:..||      ..:|
  Rat   614 MLSGPQVSPVADARDQQWATLERPRAQSNPREGQDSHLSSAGRAPTLQHP------PHQPPLRPS 672

  Fly  1277 ---KDVRK----CCHIKYT----SDWTDCSVQ-----------CGEGVKRKK----QSCTRVYKP 1315
               :|.|.    ||...:|    ..|..|.:.           |.:||...|    ..|||.:..
  Rat   673 SGARDCRHSPHGCCPDGHTPSLGPQWQGCPLAGASCLKSRYGCCPDGVSAAKGPQQAGCTRSHSS 737

  Fly  1316 DVPGTRK-RRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDW------RRCPADCSEEYQT 1373
            |..|.|. .|..|.:...|.:....|...:..:|.:..|.::...:      ..|....|..|
  Rat   738 DNTGNRPGSRAVVSKDPKIHQSQAHPSEISECRSSQFGCCYDNVAFAAGPLGEGCVGQPSYAY-- 800

  Fly  1374 RDVRCESFQGDGVEDKHCDAKKRPSKRRICNNCVRRQSRV--ISQCN------CEG-------VE 1423
             .|||                ..||.:..|.:...|...|  :.:||      |.|       .:
  Rat   801 -PVRC----------------LLPSAQGSCGDWAARWYFVGSVGRCNRFWYGGCHGNANNFATEQ 848

  Fly  1424 KRRDFCFNSH--------------------KG-----------------RIACPTRARVERHSCT 1451
            :..|.|...|                    :|                 |:..|:.:...|....
  Rat   849 ECMDTCRGQHGPRRPEAGAAGHRVHMDGGQRGPGGQQEPDWHRIEATVPRLPSPSGSPWSREQEP 913

  Fly  1452 PP---PHC----RRRSAIGSSISSRP--RGTGVSSSR-SLNSIGGSRNRGTPRSCADL------- 1499
            .|   ||.    :|....|....:||  |.|...|.| :|.....|..:..|.....|
  Rat   914 GPGQAPHIPAQGKRPRVPGLDRDARPPVRPTHSPSYRINLADSEPSLVQAAPGQAVQLFCPGNIP 978

  Fly  1500 -KEMHGYNKDG------NYQLEVRSRMVHIYCHGMNSRTPQEYVNVDP--QENYSIYYEYRTKQT 1555
             :...|:.|:|      .|||:....::                 :.|  .|:..||
  Rat   979 PEFQAGWQKEGRPISSNRYQLQADGSLI-----------------ISPLRPEDAGIY-------- 1018

  Fly  1556 NSCPPESRGHEYYNDQNSGRTHFRKLRLNIT--DLRIM 1591
             ||..:..|||.           :|::|.:|  |:.::
  Rat  1019 -SCGSQRSGHEP-----------QKIQLRVTGGDMAVL 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254
		ZnMc_ADAMTS_like	455..655	CDD:239801
		ADAMTS_CR_2	671..740	CDD:465496	5/14 (36%)
		TSP1	754..806	CDD:214559	20/51 (39%)
		ADAMTS_CR_3	815..911	CDD:437068	32/96 (33%)
		TSP1	1172..1229	CDD:214559	20/69 (29%)
		TSP1_ADAMTS	1243..1282	CDD:465950	8/64 (13%)
		TSP1_ADAMTS	1355..1405	CDD:465950	9/55 (16%)
		GON	1493..1687	CDD:462559	21/117 (18%)
Papln	XP_038969231.1	TSP1	84..135	CDD:214559	20/51 (39%)
		ADAMTS_CR_3	140..237	CDD:437068	34/100 (34%)
		ADAMTS_spacer1	239..353	CDD:461796	24/123 (20%)
		TSP1_ADAMTS	363..415	CDD:465950	7/51 (14%)
		TSP1_ADAMTS	421..479	CDD:465950	15/57 (26%)
		TSP1_ADAMTS	482..535	CDD:465950	17/58 (29%)
		TSP1_ADAMTS	543..593	CDD:465950	18/54 (33%)
		Kunitz_papilin	804..854	CDD:438678	11/65 (17%)
		Papilin_u7	863..947	CDD:374683	13/83 (16%)
		Ig	957..>1020	CDD:472250	13/88 (15%)
		Ig strand B	969..973	CDD:409389	1/3 (33%)
		Ig strand C	982..986	CDD:409389	1/3 (33%)
		Ig strand E	1003..1007	CDD:409389	0/20 (0%)
		I-set	1095..1163	CDD:400151
		Ig strand B	1108..1112	CDD:409353
		Ig strand C	1121..1125	CDD:409353
		Ig strand E	1142..1146	CDD:409353
		Ig strand F	1156..1161	CDD:409353
		IG_like	1186..1266	CDD:214653
		Ig strand B	1197..1201	CDD:409550
		Ig strand C	1209..1213	CDD:409550
		Ig strand E	1232..1236	CDD:409550
		Ig strand F	1246..1251	CDD:409550
		Ig strand G	1259..1262	CDD:409550
		PLAC	1283..1315	CDD:462560