DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and Adamtsl3

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_001101003.2	Gene:	Adamtsl3 / 308787	RGDID:	1305155	Length:	1705	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	214/989 - (21%)
Similarity:	321/989 - (32%)	Gaps:	353/989 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 NGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQ 815
            :|.|..|..::.||.|||||...|.|.|..      |:.|.|...:|::|:.|.||..:.|.|.|
  Rat    87 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPADAEDFRAQ 145

  Fly   816 QCYAMNGRNMNIPGVNPDTKWVPKYEKDA--CKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKC 878
            ||.|.|    ::.......:|:|.:...|  |.|.|....:.....|...|.|||.|..|:.|.|
  Rat   146 QCSAYN----DVQYQGHYYEWIPLHNDPAAPCALKCHARGQSLVVELAPKVLDGTRCNADTLDMC 206

  Fly   879 VNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIP 943
            ::|||:..|||.:|.|.||.|.||||.|...||..|.|...|.        ..|.|....|..:|
  Rat   207 ISGICQTVGCDRQLGSSAKKDNCGVCAGDGSTCRLVRGQTKVH--------LSPEKKEENVIAVP 263

  Fly   944 KGASNIIITQRGYPDQNFI---VLTDDRDNELLNGKFLKTYPLKFVYAGVTMQY----------- 994
            .|:.::.||.:| |...||   .|...|.....|.      |..||....|:::
  Rat   264 LGSRSVRITVKG-PALLFIESKTLQGSRGEHSFNS------PGVFVVENTTIEFQKGADRQTFKI 321

  Fly   995 ---------------TGSSSVVE---------------------------QVNTTYSWKLSRDLI 1017
                           ....|||:                           |:|:.....:....:
  Rat   322 AGPLMADFIFKTRYTVAKGSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECMDIRLKRV 386

  Fly  1018 V------------------QIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSN 1064
            |                  :..|:|..||......::.|.:....|          |||....:.
  Rat   387 VPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLP----------RWEHNPWTA 441

  Fly  1065 CDSLCEGRSHRLP-ACISTT---QGVKVAPQFCDKSAMPKIDDRACNT-DCRLNLTVTSISECSA 1124
            |...|.|...|.. .|:..:   :.::|....|..:..||: .:.||. ||...:.: ..|:|:.
  Rat   442 CSVSCGGGIQRRSFVCVEESMHAEILQVEEWKCMYAPKPKV-MQTCNLFDCPKWIAM-EWSQCTV 504

  Fly  1125 ACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEEC--------------------- 1168
            .||. |.|.:...|:    |.:..::   ..|..:..:...|||
  Rat   505 TCGR-GLRYRVVLCI----NHRGQHV---GGCNPQMKLHIKEECVIPVPCYKPKEKSPVEAKLPW 561

  Fly  1169 --------------REGCWVLSEWSTCSKSCGTGSQQREAHC----------------------- 1196
                          .|..::...||.||.:||.|.|.||..|
  Rat   562 LKQAQELEETRIATEEPKFIPEPWSACSTTCGPGIQVREVRCRVLLTFTQTETELPEEECEGPKP 626

  Fly  1197 ---------------------------------------------------------YLH---NS 1201
                                                                     .||   :.
  Rat   627 PTERPCLLEACDHSPVSRELGGPLQEKDSEMIYDWEYAGFTPCTATCLGGYQEAIAVCLHIQTHQ 691

  Fly  1202 RVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCE---KTRSVSC 1263
            .|:|.||:...:|  ..:...|:||.||           ..|.:|.||.|:..|.   :||.|.|
  Rat   692 TVNDSLCDLAHRP--PPMSQACHTEPCP-----------PRWHMGSWGACSATCGVGIQTRDVYC 743

  Fly  1264 SHPYGI-----GCGSRKPKDVRKC----C----HIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKP 1315
            .||...     .|...||..:|.|    |    ||:   :|..|...||.|.:.::.:|
  Rat   744 VHPEESPAPPEECRDEKPHALRACNQFDCPPSWHIE---EWQQCPRTCGGGTQNRRVTC------ 799

  Fly  1316 DVPGTRKRRVYVDESYC-ISRKVHRPKLRTTTKSC-RINC--KWNASDWRRCPADCSEEYQTRDV 1376
                   |::..|.|:. :|.::.:....::.||| |.:|  :..|.||.:|...|...:|.|..
  Rat   800 -------RQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPQLAAGDWSKCSVTCGVGFQRRKQ 857

  Fly  1377 RCESFQGDG----VEDKHCD-----AKKRPSKRRICN--------NCVRRQSRVISQCNCEGV-- 1422
            .|:.....|    :.:..|.     ...||.:..:|:        |...|..:::      ||
  Rat   858 VCQKLTAKGRRVPLAETLCRDLPGLPLVRPCQMPVCSKLKLGMKTNLGERGPQIL------GVRR 916

  Fly  1423 -------EKR-------RDFCFNSHKGRIACPTR------ARVERHSCTPPPHCRRRSAIGSSIS 1467
                   |||       |.:...:....|.||.|      .:.|:..     ||.:.|
  Rat   917 VYIQTREEKRINLTVGSRAYLLLNTSVIIKCPVRHFQKSLIQWEKDG-----HCLKNS------- 969

  Fly  1468 SRPRGTGVSSSRSL 1481
               :..|::.|.||
  Rat   970 ---KQLGITKSGSL 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559	18/51 (35%)
		ADAM_spacer1	937..1042	CDD:283607	27/178 (15%)
		TSP1	1172..1229	CDD:214559	21/139 (15%)
		GON	1495..1687	CDD:285848
Adamtsl3	NP_001101003.2	TSP1	90..136	CDD:214559	18/51 (35%)
		TSP1	438..>458	CDD:214559	4/19 (21%)
		TSP1	498..>527	CDD:214559	8/36 (22%)
		TSP1	583..>603	CDD:214559	10/19 (53%)
		TSP1	720..773	CDD:214559	17/52 (33%)
		TSP1	839..894	CDD:214559	11/54 (20%)
		Ig	942..1006	CDD:299845	12/54 (22%)
		Ig	1223..1291	CDD:143165
		IG_like	1313..1392	CDD:214653
		IGc2	1329..1387	CDD:197706
		TSP_1	1502..1557	CDD:278517
		PLAC	1673..1703	CDD:285849
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810