DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts16

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_001358944.1	Gene:	Adamts16 / 306664	RGDID:	1310046	Length:	1221	Species:	Rattus norvegicus

Alignment Length:	1347	Identity:	363/1347 - (26%)
Similarity:	550/1347 - (40%)	Gaps:	336/1347 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 DHEPP--DGLDDLDEEEHSAFVMPTKVYNYSLSEA------DLIYESKRNSDINSFLKESASAFA 277
            |..||  .|.|.|:..|:..      |..|.:..:      |:::..:|.....:..|..|....
  Rat    39 DPHPPSSSGSDWLETSEYDL------VSAYEVDHSGDYVSYDIMHHQRRRRRAVTQSKGDALHLR 97

  Fly   278 MTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEG-----EEHPGPE 337
            :.|             |:::       |||.|:..::.:....|  ::.|.:|     :..|..|
  Rat    98 LKG-------------PRHD-------LHLDLKAASNLMAPGFM--VQTLGKGGTKSVQMFPAEE 140

  Fly   338 TEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQP--------VNRT---- 390
                      .|||.|.:....:|.|::|.|.|:.|.|:|......::|        :||:
  Rat   141 ----------NCFYQGSLRSQGNSSVALSTCQGLLGMIRTKDADYFLKPLPPQLTSKLNRSAQGG 195

  Fly   391 SSDEVLHRVFRKSQRNA-----------RHAVSKFELGLDDFMSKLEQVQE-------------- 430
            |...:|::  |.::..|           :..:::..|..|:|...|.:.|.
  Rat   196 SPSHILYK--RSTEHQAPRENEVLMITRKRDLARTHLHHDNFHLGLSRKQHFCGRRKKYMPQPPD 258

  Fly   431 -------EEQKSKSR-KLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMSIV 486
                   :|.|..|| |.:..|.|    .|:...:|.|:.||..|.|.|| |::..|:|.::::|
  Rat   259 DNLYILPDEYKPSSRPKRSLLKSH----RNEELNVETLVVVDRKMLQSHGHENITTYVLTILNMV 319

  Fly   487 SSIFADASIGNSIRILLVRLISLPNINDQ-----THSSNEMLKHFCQF----INQSGYERDTAML 542
            |::|.|.:||.:|.|::|.||.|.  ::|     :|.::..|..|||:    :.:.|...|.|:|
  Rat   320 SALFKDGTIGGNINIVIVGLILLE--DEQPGLAISHHADRTLTSFCQWQSGLMGKDGARHDHAIL 382

  Fly   543 ITREPICGSVPGKICHMLGLAELGTVCSS-SSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDDK 605
            :|...|| |...:.|..||.|.:..:||. .||::.:|:||..|||:|||.||...|.|| :.:.
  Rat   383 LTGLDIC-SWKNEPCDTLGFAPISGMCSKYRSCTVNEDSGLGLAFTIAHESGHNFGMVHDGEGNM 446

  Fly   606 CMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYG-TER 669
            |    .:...|    |||..:......:|||.|||.::.:||......||.........|. .|:
  Rat   447 C----KKSEGN----IMSPTLAGRNGVFSWSSCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEK 503

  Fly   670 LPGEIYSLDAQCQLSFGNDFGYCPTD---EECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSG 731
            |||::|..:.||:..||.....|..|   :.||.|||:|.    ..:|.:..:|.|:||.||..
  Rat   504 LPGQLYDANTQCKWQFGEKAKLCMLDFRKDICKALWCHRI----GRKCETKFMPAAEGTLCGQD- 563

  Fly   732 HWCQRGKCVSNKHGYG----RQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTG 792
            .||:.|:||.    ||    :..:|.|..|:|::|||.||||||....|.|..|.|.:|||:|.|
  Rat   564 MWCRGGQCVK----YGDEGPKPTHGHWSDWSPWSPCSRTCGGGVSHRDRLCTNPRPSHGGKFCQG 624

  Fly   793 SRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY-------EKDACKLFCR 850
            |.:..:.||:.:||..|:..|..||...|.:...        .|:.|:       ::|.|||:|.
  Rat   625 SARTLKLCNSQKCPLDSVGFRAAQCAEYNSKRFR--------GWLYKWTPYTQVEDQDLCKLYCI 681

  Fly   851 MDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTC--HE 913
            .:....:|.|.:.|.|||.|:.||.:.|::|:|...||||.|.|.|..|.||||:|.|..|  |.
  Rat   682 AEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGMCEKVGCDNVLGSDATEDSCGVCQGNNSDCVMHR 746

  Fly   914 VTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFL 978
                       ||...|.|....|:|..||.||.:|.|.:... ..::|.:.:......|||.:.
  Rat   747 -----------GLYSKNHPTNQYYHVVTIPSGARSIHIYETNI-STSYISVRNSVKKYYLNGHWS 799

  Fly   979 KTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTID 1043
            ..:|.::.::|.|..|..|....|.:.:|  ...:..|||:::....:|.
  Rat   800 VDWPGRYKFSGTTFNYRRSYKEPESLTST--GPTNETLIVELLFQGRNPG--------------- 847

  Fly  1044 KPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACNT 1108
                       ..||...|       ...|.|.|           .||.....|:.:
  Rat   848 -----------VAWEFSVP-------RSGSKRTP-----------PPQPSYSWAILR-------- 875

  Fly  1109 DCRLNLTVTSISECSAAC--GELGTREKTYACVQTFTNMQRSNIVDMSYCKLKF-DVAYHEECR- 1169
                       ||||.:|  |::.::...|..::.        :|:.|:|..|. .|.....|:
  Rat   876 -----------SECSVSCGGGKMSSKAGCYRDLKV--------LVNASFCNPKTRPVPALVPCKV 921

  Fly  1170 EGC---WVLSEWSTCSKSCGTGSQQREAHC----YLHNSRVSDDLCNPRTKPHLNTLIGICNTES 1227
            ..|   |.:..|||||::||.|:|.|..||    :.....:|..|| |:..|.|:.   .||::|
  Rat   922 SACPPSWSVGNWSTCSRTCGGGTQSRPVHCTRRAHYREESISASLC-PQPAPPLHQ---ACNSQS 982

  Fly  1228 CPTYTKSPNALAVSNWVIGEWGECNEWCEK---TRSVSC--SHP-------YGIGCGSR-KPKDV 1279
            ||           ..|..|.|.||:..|.|   .|:|:|  ::|       :...|.|. ||:..
  Rat   983 CP-----------PAWSTGPWAECSRTCGKGWRKRTVACKSTNPSARAQLLHDTACTSEPKPRTH 1036

  Fly  1280 RKC----CHIKY------TSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCIS 1334
            :.|    || |:      .|.|:.||..|..|.:.:...|...|   |.|..:.        ..|
  Rat  1037 QVCLLKRCH-KHKKLQWLVSAWSPCSATCQRGTQHRVLRCAEKY---VSGKYRE--------LAS 1089

  Fly  1335 RK-VHRPK--LRTTTKSCRINC--------------KWNASDWRRCPADCSEEYQTRDVRCESFQ 1382
            :| :|.||  |........|.|              .|.||.|..|.|.|....|.|.|:| ...
  Rat  1090 KKCLHLPKPDLELERACGLIPCPKHPPYAASGPPRGSWFASPWSLCTASCGGGVQRRTVQC-LLG 1153

  Fly  1383 GDGVEDKHCDAKKRPSKRRICNNCVRRQSRVISQCNCEGVEKRRDFC 1429
            |....|  |...::|.....||...           |...|||..||
  Rat  1154 GQPASD--CFLHEKPETSTACNTHF-----------CPIAEKRDTFC 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	26/124 (21%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	72/211 (34%)
		Reprolysin	457..655	CDD:279729	72/209 (34%)
		Salp15	<696..745	CDD:288931	18/48 (38%)
		TSP1	754..806	CDD:214559	24/51 (47%)
		ADAM_spacer1	937..1042	CDD:283607	23/104 (22%)
		TSP1	1172..1229	CDD:214559	23/63 (37%)
		GON	1495..1687	CDD:285848
Adamts16	NP_001358944.1	Pep_M12B_propep	57..202	CDD:366707	33/182 (18%)
		ZnMc_ADAMTS_like	287..488	CDD:239801	72/211 (34%)
		ADAM_CR_2	505..572	CDD:375321	25/71 (35%)
		TSP1	586..638	CDD:214559	24/51 (47%)
		ADAM_spacer1	745..855	CDD:368694	30/149 (20%)
		TSP1	928..984	CDD:214559	22/59 (37%)
		TSP1	987..>1016	CDD:214559	10/28 (36%)
		TSP1	1055..1112	CDD:214559	17/67 (25%)
		TSP1	1125..1178	CDD:214559	17/66 (26%)
		PLAC	1187..1217	CDD:370061	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820