Protein Alignment AdamTS-A and Adamts3

DIOPT Version :10

• Sequence 1: NP_996218.1
• Gene: AdamTS-A / 41887
• FlyBaseID: FBgn0286071
• Length: 1688
• Species: Drosophila melanogaster
• Sequence 2: NP_001381638.1
• Gene: Adamts3 / 305253
• RGDID: 1310750
• Length: 1203
• Species: Rattus norvegicus
• Alignment Length: 1423
• Identity: 353/1423 - (24%)
• Similarity: 535/1423 - (37%)
• Gaps: 394/1423 - (27%)

  Fly   234 EEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMS-NEIWDPHPQ-- 295
            ||.....:|||.|.    |.:|:      :.:::.||....:..::..::..| .::.....|
  Rat    27 EEMVQIDLPTKRYR----EYELV------TPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEQLF 81

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRH-------------- 346
            :|:..|||..||.||.:..|:...::..   ..|....||..|:....:.|
  Rat    82 FNVTAFGRDFHLRLRPNTHFIAPGAVVE---WHETAPRPGNTTDPRNSRPHRSSSEGGWRSEPLQ 143

  Fly   347 LGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNR-TSSDEV---LHRVFRKS--QR 405
            ..|.|.|.:.|.|.:.|::|.|.|:.|.||:......|:|:.| ...||.   :|.|:::|  :|
  Rat   144 TSCAYVGDIMDVPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMDEENGRIHIVYKRSAMER 208

  Fly   406 NAR-------HAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAV 463
            ..|       :..|..| ||||..:....:.::..::     .|::||..:.|   |.:|||:.|
  Rat   209 APRDVSEDVYYKESNLE-GLDDLGTVYSNIGQQLNET-----TRRRRHAGEND---YNIEVLLGV 264

  Fly   464 DNSMKQFHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNIND----QTHSSNEML 523
            |:|:.:||| |.:|.|:|.||:||:.|:.|.|:|..|.::|||:|.|.....    :..:.:..|
  Rat   265 DDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSL 329

  Fly   524 KHFCQFINQS-------GYERDTAMLITRE-----------PICGSVPGKICHMLGLAELGTVCS 570
            ::.|::..|.       ....|.|:.:||:           |:.|     :||.:
  Rat   330 ENVCRWACQQQKSDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTG-----MCHPV---------- 379

  Fly   571 SSSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWS 634
             .||::..:.|..:||.:|||.||:|.|.|| ..::|      .:...:..:|:.::....|.:.
  Rat   380 -RSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRC------GDETAMGSVMAPLVQAAFHRYH 437

  Fly   635 WSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP---TDE 696
            ||:||...:..::...|  ||......|.......|||..||:|.||:..||..:..|.   |.:
  Rat   438 WSRCSGQELKRYIHSYD--CLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFD 500

  Fly   697 ECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFT 761
            .||:|||:..  ::...|.:...|..|||.| ::|.||.:|.|:. |:...::.:|.||.||.|.
  Rat   501 PCKQLWCSHP--DNPYFCKTKKGPPLDGTEC-AAGKWCYKGHCMW-KNANQQKQDGNWGSWTKFG 561

  Fly   762 PCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMN 826
            .||.|||.||:...|:||.|.|.|||:.|.|...:|:.|||.:|.....|.|.|||   ..||.:
  Rat   562 SCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQC---QQRNSH 623

  Fly   827 IPGVNPDTKWVPKYEKDA---CKLFCRMDMKVTYFMLKSMVTDGTSCAV-DSFDKCVNGICRPAG 887
            ....|....|:|....|:   |.|:|:.........:|.:|.|||.|:. |.:..||.|.|...|
  Rat   624 FDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVG 688

  Fly   888 CDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL-VSNLLGLNDGNEPNKTLYYVTRIPKGASNIII 951
            ||.|:.|....||||||.|.|..|..|.|... ....||...|       .:|  :||||.||.:
  Rat   689 CDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRG-------AFV--LPKGARNISL 744

  Fly   952 TQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYS-WKLSRD 1015
            .:.........:......:.:||||..:.....|:..||...|    ::.:.:.|.:: ..|...
  Rat   745 AETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDY----NIEDDIETLHTDGPLHDP 805

  Fly  1016 LIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACI 1080
            :||.||     |.:......|:|.|.|.:                     ||
  Rat   806 VIVLII-----PQENDTRSSLTYKYIIHE---------------------DS------------- 831

  Fly  1081 STTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNM 1145
                                               |.:|:..:....||.|.|
  Rat   832 -----------------------------------VPTINSNNVIQEELDTFE------------ 849

  Fly  1146 QRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNP 1210
                                       |.|..||.|||.||.|.|..:..|    .|.||.....
  Rat   850 ---------------------------WALKSWSQCSKPCGGGFQYTKYGC----RRKSDSKMVH 883

  Fly  1211 RTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRK 1275
            |:                                         :||.               ::|
  Rat   884 RS-----------------------------------------FCEV---------------NKK 892

  Fly  1276 PKDVRKCCHIKYTSD-------WTDCSVQCG-EGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYC 1332
            ||.:|:.|:|:..:.       |..||..|| .|.:.:...|   .:|...||.:.   |...||
  Rat   893 PKPIRRMCNIQECTHPLWAAEAWEHCSRSCGSSGYQLRTVRC---LQPLQDGTNRS---VHSRYC 951

  Fly  1333 ISRKVHRPKLRTTTKSC-RINC--KWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAK 1394
            :.   .||:.|   :.| ||.|  :|....|..|...|.|..:.|.|.|.:  ||     |||.:
  Rat   952 LG---ERPESR---RPCNRIPCPAQWKTGPWNECSVTCGEGTEVRQVLCRT--GD-----HCDGE 1003

  Fly  1395 KRPSKRRICNNCVRRQSRVISQCN---CEG-------VEKRRDFCFNSHKGRIACPTRARVERHS 1449
            | |...|.|.         :..||   |.|       :|....:|.......:.|.:.::  |..
  Rat  1004 K-PESVRACQ---------LPPCNDEPCLGDKSIFCQMEVLARYCSIPGYSELCCESCSK--RSG 1056

  Fly  1450 CTPPPHCRRRSAIGSSI----SSRPRGTGVSSSRSLNSIGGSRNRGTPRSCADLKEMHGYNKDGN 1510
            ..|||:.:..:.|.|..    |..||.. |..:..|....|||        ||.|.:...:...|
  Rat  1057 TLPPPYLQEAAEIHSDAIFGPSDLPRSL-VMPTPFLPYYSGSR--------ADKKSLSSVSSVAN 1112

  Fly  1511 YQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQENYSIYY------EYRTKQTNSCPPES 1562
                                 |..|.........|:.:      |..||...|.||.|
  Rat  1113 ---------------------PSAYAAFRSSSRASVSFPRKKAQEGGTKTPVSMPPSS 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	<295..394	CDD:460254	30/115 (26%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	61/223 (27%)
		ADAMTS_CR_2	671..740	CDD:465496	26/71 (37%)
		TSP1	754..806	CDD:214559	26/51 (51%)
		ADAMTS_CR_3	815..911	CDD:437068	36/99 (36%)
		TSP1	1172..1229	CDD:214559	16/56 (29%)
		TSP1_ADAMTS	1243..1282	CDD:465950	6/38 (16%)
		TSP1_ADAMTS	1355..1405	CDD:465950	17/49 (35%)
		GON	1493..1687	CDD:462559	14/76 (18%)
Adamts3	NP_001381638.1	Pep_M12B_propep	43..201	CDD:460254	37/166 (22%)
		ZnMc_ADAMTS_like	256..457	CDD:239801	62/224 (28%)
		ADAMTS_CR_2	472..540	CDD:465496	26/70 (37%)
		TSP1	554..605	CDD:214559	26/50 (52%)
		ADAMTS_CR_3	611..712	CDD:437068	38/103 (37%)
		ADAMTS_spacer1	714..828	CDD:461796	30/131 (23%)
		TSP1_ADAMTS	850..905	CDD:465950	24/114 (21%)
		TSP1_ADAMTS	910..967	CDD:465950	19/68 (28%)
		TSP1_ADAMTS	971..1016	CDD:465950	17/61 (28%)
		PLAC	1024..1052	CDD:462560	3/27 (11%)