DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts3

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_001381638.1	Gene:	Adamts3 / 305253	RGDID:	1310750	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	1423	Identity:	353/1423 - (24%)
Similarity:	535/1423 - (37%)	Gaps:	394/1423 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 EEHSAFVMPTKVYNYSLSEADLIYESKRNSDINSFLKESASAFAMTGTYRNMS-NEIWDPHPQ-- 295
            ||.....:|||.|.    |.:|:      :.:::.||....:..::..::..| .::.....|
  Rat    27 EEMVQIDLPTKRYR----EYELV------TPVSTNLKGHYLSHILSANHKKRSPRDVSSNSEQLF 81

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRH-------------- 346
            :|:..|||..||.||.:..|:...::..   ..|....||..|:....:.|
  Rat    82 FNVTAFGRDFHLRLRPNTHFIAPGAVVE---WHETAPRPGNTTDPRNSRPHRSSSEGGWRSEPLQ 143

  Fly   347 LGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNR-TSSDEV---LHRVFRKS--QR 405
            ..|.|.|.:.|.|.:.|::|.|.|:.|.||:......|:|:.| ...||.   :|.|:::|  :|
  Rat   144 TSCAYVGDIMDVPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMDEENGRIHIVYKRSAMER 208

  Fly   406 NAR-------HAVSKFELGLDDFMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAV 463
            ..|       :..|..| ||||..:....:.::..::     .|::||..:.|   |.:|||:.|
  Rat   209 APRDVSEDVYYKESNLE-GLDDLGTVYSNIGQQLNET-----TRRRRHAGEND---YNIEVLLGV 264

  Fly   464 DNSMKQFHG-EDLQPYILILMSIVSSIFADASIGNSIRILLVRLISLPNIND----QTHSSNEML 523
            |:|:.:||| |.:|.|:|.||:||:.|:.|.|:|..|.::|||:|.|.....    :..:.:..|
  Rat   265 DDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSL 329

  Fly   524 KHFCQFINQS-------GYERDTAMLITRE-----------PICGSVPGKICHMLGLAELGTVCS 570
            ::.|::..|.       ....|.|:.:||:           |:.|     :||.:
  Rat   330 ENVCRWACQQQKSDPNHAEHHDHAIFLTRQDFGPAGMQGYAPVTG-----MCHPV---------- 379

  Fly   571 SSSCSIVQDTGLPTAFTMAHELGHILNMNHD-DDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWS 634
             .||::..:.|..:||.:|||.||:|.|.|| ..::|      .:...:..:|:.::....|.:.
  Rat   380 -RSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRC------GDETAMGSVMAPLVQAAFHRYH 437

  Fly   635 WSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP---TDE 696
            ||:||...:..::...|  ||......|.......|||..||:|.||:..||..:..|.   |.:
  Rat   438 WSRCSGQELKRYIHSYD--CLLDDPFEHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFD 500

  Fly   697 ECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFT 761
            .||:|||:..  ::...|.:...|..|||.| ::|.||.:|.|:. |:...::.:|.||.||.|.
  Rat   501 PCKQLWCSHP--DNPYFCKTKKGPPLDGTEC-AAGKWCYKGHCMW-KNANQQKQDGNWGSWTKFG 561

  Fly   762 PCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMN 826
            .||.|||.||:...|:||.|.|.|||:.|.|...:|:.|||.:|.....|.|.|||   ..||.:
  Rat   562 SCSRTCGTGVRFRTRQCNNPTPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQC---QQRNSH 623

  Fly   827 IPGVNPDTKWVPKYEKDA---CKLFCRMDMKVTYFMLKSMVTDGTSCAV-DSFDKCVNGICRPAG 887
            ....|....|:|....|:   |.|:|:.........:|.:|.|||.|:. |.:..||.|.|...|
  Rat   624 FDYQNTKHHWLPHEHPDSKKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVG 688

  Fly   888 CDNELNSIAKLDKCGVCEGRNDTCHEVTGNLL-VSNLLGLNDGNEPNKTLYYVTRIPKGASNIII 951
            ||.|:.|....||||||.|.|..|..|.|... ....||...|       .:|  :||||.||.:
  Rat   689 CDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGKTRG-------AFV--LPKGARNISL 744

  Fly   952 TQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYS-WKLSRD 1015
            .:.........:......:.:||||..:.....|:..||...|    ::.:.:.|.:: ..|...
  Rat   745 AETRETKNVLAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDY----NIEDDIETLHTDGPLHDP 805

  Fly  1016 LIVQIISLDVSPSKRQDTVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACI 1080
            :||.||     |.:......|:|.|.|.:                     ||
  Rat   806 VIVLII-----PQENDTRSSLTYKYIIHE---------------------DS------------- 831

  Fly  1081 STTQGVKVAPQFCDKSAMPKIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNM 1145
                                               |.:|:..:....||.|.|
  Rat   832 -----------------------------------VPTINSNNVIQEELDTFE------------ 849

  Fly  1146 QRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNP 1210
                                       |.|..||.|||.||.|.|..:..|    .|.||.....
  Rat   850 ---------------------------WALKSWSQCSKPCGGGFQYTKYGC----RRKSDSKMVH 883

  Fly  1211 RTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEKTRSVSCSHPYGIGCGSRK 1275
            |:                                         :||.               ::|
  Rat   884 RS-----------------------------------------FCEV---------------NKK 892

  Fly  1276 PKDVRKCCHIKYTSD-------WTDCSVQCG-EGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYC 1332
            ||.:|:.|:|:..:.       |..||..|| .|.:.:...|   .:|...||.:.   |...||
  Rat   893 PKPIRRMCNIQECTHPLWAAEAWEHCSRSCGSSGYQLRTVRC---LQPLQDGTNRS---VHSRYC 951

  Fly  1333 ISRKVHRPKLRTTTKSC-RINC--KWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAK 1394
            :.   .||:.|   :.| ||.|  :|....|..|...|.|..:.|.|.|.:  ||     |||.:
  Rat   952 LG---ERPESR---RPCNRIPCPAQWKTGPWNECSVTCGEGTEVRQVLCRT--GD-----HCDGE 1003

  Fly  1395 KRPSKRRICNNCVRRQSRVISQCN---CEG-------VEKRRDFCFNSHKGRIACPTRARVERHS 1449
            | |...|.|.         :..||   |.|       :|....:|.......:.|.:.::  |..
  Rat  1004 K-PESVRACQ---------LPPCNDEPCLGDKSIFCQMEVLARYCSIPGYSELCCESCSK--RSG 1056

  Fly  1450 CTPPPHCRRRSAIGSSI----SSRPRGTGVSSSRSLNSIGGSRNRGTPRSCADLKEMHGYNKDGN 1510
            ..|||:.:..:.|.|..    |..||.. |..:..|....|||        ||.|.:...:...|
  Rat  1057 TLPPPYLQEAAEIHSDAIFGPSDLPRSL-VMPTPFLPYYSGSR--------ADKKSLSSVSSVAN 1112

  Fly  1511 YQLEVRSRMVHIYCHGMNSRTPQEYVNVDPQENYSIYY------EYRTKQTNSCPPES 1562
                                 |..|.........|:.:      |..||...|.||.|
  Rat  1113 ---------------------PSAYAAFRSSSRASVSFPRKKAQEGGTKTPVSMPPSS 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	31/125 (25%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	61/223 (27%)
		Reprolysin	457..655	CDD:279729	60/221 (27%)
		Salp15	<696..745	CDD:288931	17/48 (35%)
		TSP1	754..806	CDD:214559	26/51 (51%)
		ADAM_spacer1	937..1042	CDD:283607	25/105 (24%)
		TSP1	1172..1229	CDD:214559	16/56 (29%)
		GON	1495..1687	CDD:285848	14/74 (19%)
Adamts3	NP_001381638.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010