DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts8

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_003750503.1	Gene:	Adamts8 / 300475	RGDID:	1308511	Length:	905	Species:	Rattus norvegicus

Alignment Length:	1090	Identity:	310/1090 - (28%)
Similarity:	473/1090 - (43%)	Gaps:	281/1090 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 ELPQSTHPLANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAFVMPTKVYNYSLSEAD 254
            :||..  ||....||.|.|                        ..:.|..|:||:
  Rat    19 QLPPP--PLVCGAPARPGT------------------------RTQASELVVPTR---------- 47

  Fly   255 LIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHNH 319
                          |..|||..|                  ::|:.||:...|.|..||||:
  Rat    48 --------------LPSSASELA------------------FHLSAFGQSFVLRLAPDASFL--- 77

  Fly   320 SMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLI 384
             ....:|.:.|    |....|..|....|||:||.|..:..|:.::|||||::|....:.....|
  Rat    78 -APEFKIERLG----GSSAAAGGEPGLRGCFFSGTVNGERESLAAMSLCGGLSGSFLLAGEEFTI 137

  Fly   385 QPVNRTSSDEVLHRVFR--KSQRNARHAVS-----------KFELGLDDFMSKLEQVQEEEQKSK 436
            ||.....|.:..||:.|  ..||.....::           ::|:.:.|...:..:..||:::..
  Rat   138 QPQGAGDSLDQPHRLQRWGPGQRREDPGLAAAEVFPLPQGLEWEVEMGDGQGQRRRDNEEDRERD 202

  Fly   437 SRKLNRKKRHYADVD-------------NQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSS 488
            ...|.::.....:|.             ::...:|:|:..|.||..|:|.|||.:||.:||:.:.
  Rat   203 KEGLRKETEDSREVTPPFGSKTRSKRFVSEARFVEILLVADASMAAFYGTDLQNHILTVMSMAAR 267

  Fly   489 IFADASIGNSIRILLVRLISL------PNINDQTHSSNEMLKHFCQFINQSGYER---------D 538
            |:...||.|||.:::|:::.:      |.::|   :....|::||.:  |..:.:         |
  Rat   268 IYKHPSIRNSINLVVVKVLIVEEEGWGPEVSD---NGGLTLRNFCSW--QRRFNKPSDRHPEHYD 327

  Fly   539 TAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDD 602
            ||:|.||:..|..  |:.|..||:|::||:|. :.|||:::|.||..|:|:||||||:|:|.|||
  Rat   328 TAILFTRQNFCRK--GEQCDTLGMADVGTICDPNKSCSVIKDEGLQAAYTLAHELGHVLSMPHDD 390

  Fly   603 DDKCMPYVTRQNNNKVLHIMSSVMGIHMH-PWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIPYG 666
            ...|:........   .|:|:... ||:: ...||.||..:::|.|:.....||..:..:.:|..
  Rat   391 SKPCVRLFGPMGK---YHMMAPFF-IHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSVLPLP 451

  Fly   667 TERLPGE--IYSLDAQCQLSFGNDFGYCP---TDEECKRLWCNRTSGNSNEQ-CASSN--LPWAD 723
            | .|||.  :|.||.||:..||.||.:||   .::.|.:|||...  :|:|. |.:.|  |.|||
  Rat   452 T-GLPGHSTLYELDQQCKQIFGPDFRHCPNTSVEDICVQLWCRHR--DSDEPICHTKNGSLLWAD 513

  Fly   724 GTPCGSSGHWCQRGKCVSNKHGYGRQ--VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENG 786
            ||||| .||.|..|.||..:.....:  |:|.||||.|:..||.|||||:|.|.|||:.|.|:||
  Rat   514 GTPCG-PGHLCLDGSCVLREEVENPKAVVDGDWGPWGPWGQCSRTCGGGIQFSNRECDNPAPQNG 577

  Fly   787 GKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRN-MNIPGVNPDTKWVPKYE----KDACK 846
            |::|.|.|.||:||.|.:|||.....|||||...|..| .::.|  ...:|||||.    :|.||
  Rat   578 GRFCLGERVKYQSCKTEECPPNGKSFREQQCEKYNAYNHTDLDG--NFLQWVPKYSGVSPRDRCK 640

  Fly   847 LFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTC 911
            ||||...:..:.:.::.|.|||.|..|:...||.|.|..||||:.:||..||||||||.|:...|
  Rat   641 LFCRARGRSEFKVFETKVIDGTLCGPDTLAICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTAC 705

  Fly   912 HEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQRGYP----DQNFIVLTDDRDNEL 972
            .:|:|:....: .|.||          :..||.||:||.:.||.:|    |.:::.|.......|
  Rat   706 RKVSGSFTPFS-YGYND----------IVTIPAGATNIDVKQRSHPGVQNDGSYLALKTANGQYL 759

  Fly   973 LNGKF-LKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISL--DVSPSKRQDTV 1034
            |||.. :.......:..|..::|:||.:.:|::.:..:  |...|.||::::  :|.|.|
  Rat   760 LNGNLAISAIEQDILMKGTILKYSGSMATLERLQSFQA--LPEPLTVQLLTVSGEVFPPK----- 817

  Fly  1035 LLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMP 1099
             :.|::.:....|:.
  Rat   818 -VKYTFFVPNDTDFN-------------------------------------------------- 831

  Fly  1100 KIDDRACNTDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAY 1164
                                                   ||:......:||:.        .:.|
  Rat   832 ---------------------------------------VQSSKERASTNIIQ--------SLPY 849

  Fly  1165 HEECREGCWVLSEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLCNPRTKP 1214
            .|      |||.:||.|..:||.|.|:|...|...:.:.| |.|:...||
  Rat   850 AE------WVLGDWSECPSTCGGGWQRRTVECRDPSGQAS-DTCDEALKP 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	31/107 (29%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	72/216 (33%)
		Reprolysin	457..655	CDD:279729	72/214 (34%)
		Salp15	<696..745	CDD:288931	23/51 (45%)
		TSP1	754..806	CDD:214559	30/51 (59%)
		ADAM_spacer1	937..1042	CDD:283607	28/111 (25%)
		TSP1	1172..1229	CDD:214559	17/43 (40%)
		GON	1495..1687	CDD:285848
Adamts8	XP_003750503.1	Pep_M12B_propep	49..152	CDD:279848	36/128 (28%)
		Reprolysin	234..444	CDD:279729	74/220 (34%)
		ZnMc_ADAMTS_like	234..441	CDD:239801	73/217 (34%)
		ADAM_CR	463..529	CDD:301627	31/68 (46%)
		TSP1	545..597	CDD:214559	30/51 (59%)
		ADAM_spacer1	706..825	CDD:283607	33/137 (24%)
		TSP1	852..903	CDD:214559	17/42 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8136
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46150
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820