DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Adamts12

DIOPT Version :10

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_001099890.2 Gene:Adamts12 / 294809 RGDID:1307323 Length:1599 Species:Rattus norvegicus


Alignment Length:1482 Identity:353/1482 - (23%)
Similarity:535/1482 - (36%) Gaps:501/1482 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   364 SVSLCGGMTGYIKTSFGALLIQPVNR---TSSDEVLHRVFRKSQRNARHAVSKFELGLDDFM--S 423
            ::|.|.|:||:.....|...|:||.:   |......|.::|:....... ..:...||.|.:  |
  Rat   158 ALSACQGLTGFFHLPHGDFFIEPVKKHPLTEEGYQPHVIYRRQSYRVPE-TKEPTCGLKDSLDNS 221

  Fly   424 KLEQVQEEEQKSK---SRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-EDLQPYILILMS 484
            ..:::|.|:.:.|   ||.|:|:     .:..:.: :|.|:..|..|.::|| |:::.|||.:|:
  Rat   222 VKQELQREKWERKNWPSRSLSRR-----SISKERW-VETLVVADTKMVEYHGSENVESYILTIMN 280

  Fly   485 IVSSIFADASIGNSIRILLVRLISLPNINDQ----THSSNEMLKHFCQF---INQSG----YERD 538
            :|:.:|.:.||||::.|::||||.|.. .:|    .|.:.:.|..||::   ||...    ...|
  Rat   281 MVTGLFHNPSIGNAVHIVVVRLILLEE-EEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHD 344

  Fly   539 TAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHD- 601
            .|:||||:.||..| .:.|..|||::|..:|. ..||:|.:|:|||.|||:||||||...:.|| 
  Rat   345 VAVLITRKDICAGV-NRPCETLGLSQLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDG 408

  Fly   602 DDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLE---------T 657
            .::.|.| |.|..     :|||..:.....|.:|||||:.:::.||::....||:         :
  Rat   409 KENDCEP-VGRHP-----YIMSQQIQYDPTPLTWSKCSKEYITRFLDRGRGFCLDDVPRKKGLKS 467

  Fly   658 SVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEE-CKRLWCNRTSGNSNEQCASSNLPW 721
            :|.|         ||.||.:..||||.:|.:..:|...|. |:.|||: ..|    .|.|.....
  Rat   468 NVIA---------PGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCS-VKG----FCRSKLDAA 518

  Fly   722 ADGTPCGSSGHWCQRGKCVSNKHGYGRQ---VNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVP 783
            ||||.||.. .||..|||::    .|::   :.||||.|:|::.||.|||.|.|.:.|.||.|.|
  Rat   519 ADGTRCGEK-KWCMAGKCIT----VGKKPESIPGGWGRWSPWSHCSRTCGAGAQSAERLCNNPEP 578

  Fly   784 ENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE-KDACKL 847
            :.|||||||.||:||.||.|.|...:...|:.||...:    .:|..|...:|.|.:. ...|:|
  Rat   579 KFGGKYCTGERKRYRLCNVHPCRSDTPTFRQMQCSEFD----TVPYKNQFYRWFPVFNPAHPCEL 639

  Fly   848 FCR-MDMKVTYFMLKSMVTDGTSC--AVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRND 909
            :|| :|.:.:..||:::: |||.|  ..:|.:.|:||||:..|||.|::|.|..|:||||.|...
  Rat   640 YCRPIDEQFSERMLEAVI-DGTPCFEGGNSRNVCINGICKRVGCDYEIDSNATEDRCGVCLGDGS 703

  Fly   910 TCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTRIPKGASNIIITQ---RGYPDQNFIVL-TDDRDN 970
            .|..|..........|..|          :..|||||.:|.:.:   .|    ||:.: ::|.:.
  Rat   704 ACQTVKKVFRQKEGSGYID----------IGLIPKGARDIRVMEIKAAG----NFLAIRSEDPEK 754

  Fly   971 ELLNGKFLKTYPLKFVYAGVTMQYTGSSSVV---------EQVNTTYSWKLSRDLIVQIISLDVS 1026
            ..|||.|:..:...:..||...||.....:.         |.|     |       :|::....:
  Rat   755 YYLNGGFIIQWNGNYKLAGTVFQYDRKGDLERLMAPGPTNESV-----W-------LQLLFQVTN 807

  Fly  1027 PSKRQDTVLLSYSYTIDKPP-DYEAEVEIYRWEMQAPSNCDSLC-EGRSHRLPACISTTQGVKVA 1089
            |.       :.|.||:.|.. |.:.|..:|.|:....:.|...| .|...:...|:....|: |.
  Rat   808 PG-------IKYEYTVRKDGLDNDVEKLLYFWQFGRWTECSVTCGTGIRRQTAHCVKKGHGI-VK 864

  Fly  1090 PQFCDKSAMPKIDDRAC-NTDCRLNLTVTSISECSAACGELGTREKTYACVQTF-TNMQRSNIVD 1152
            ..||:....|.:..:.| ..||...........||..||..|.:::|..|:||. ::.|.....|
  Rat   865 TTFCNPETQPSVRQKKCYEKDCPPRWWAGEWEACSMTCGPYGEKKRTVLCIQTMGSDEQALPATD 929

  Fly  1153 MSY-CKLKFDVAYHEE--CREGCWVLSEWSTCSKSCGTGSQQREAHCYLH-----------NSRV 1203
            ..: .|.|..|:.:.:  |... |.:..||.||.|||.|.:.|...|..:           |||.
  Rat   930 CQHLLKPKTLVSCNRDILCPSD-WTVGNWSECSVSCGGGVRIRSVTCAKNLNEPCDKTRKPNSRA 993

  Fly  1204 SDDLC-----------------------NPRT------KP------------------------- 1214
               ||                       ||.|      ||                         
  Rat   994 ---LCGLQQCPFSRRVLKPNKDTVPSGKNPTTSEHDHFKPIPASTSRPTPLSTPTVPESVSTSTP 1055

  Fly  1215 -------------------------------HLNTLIG--------------------------- 1221
                                           |:.|.:|                           
  Rat  1056 TINSLGSTITSQEEPDGIGWQNNSTQAEEDSHIPTSVGSTSQTPLTSWSWSMQPDDENVSSSAIG 1120

  Fly  1222 ----------------------------------------------------------------- 1221
                                                                             
  Rat  1121 PTSESDFWATTSDSGLSSSNAMTWQVTPFYSTATTEPEVEIHSGSGEDSDQPLNKEENNSVLWNK 1185

  Fly  1222 -------------------------ICNTESCPTY------------------------------ 1231
                                     :....|.|.:                              
  Rat  1186 IRVPERDAPMEMDAEIPLGPPPTSYVTEESSWPPFSTMMKSSLPAWSFKNETPRDEGMITEKSGN 1250

  Fly  1232 ----------TKSPNAL------------------------------------------------ 1238
                      |.||..|                                                
  Rat  1251 IPLPLGGDHQTTSPEKLGNNDQLASANSTNPTQGSGPVLTEEDASTLIEEGFLLNASNYKHLMKD 1315

  Fly  1239 -AVSNWVIGEWGECNEWC---EKTRSVSCSHPYGIGCGSRKPKDVRKCCHIK-----YTSDWTDC 1294
             :.::|::|.|.:|:..|   ...|||.||......|.:.:..|..|.||::     ...:|:.|
  Rat  1316 HSPAHWIVGNWSKCSTTCGLGAYWRSVECSTGMNADCAAIQRPDPAKKCHLRPCAGWRVGNWSKC 1380

  Fly  1295 SVQCGEGVKRKKQSCT------RVYKP-------DVP---------------------------- 1318
            |..|..|.|.::..|.      |..:|       .||                            
  Rat  1381 SRNCSGGFKIREVQCMDGVDHHRSLRPFHCQFLAGVPPPLSMSCNLEPCEEWKVEPWSQCSRSCG 1445

  Fly  1319 -GTRKRRVYVDESYCISRKVHRPKLRTTTKSC--RINCKWNASDWRRCPADCSEEYQTRDVRCES 1380
             |.::|.|:.....|...|  ||   .:|..|  .:.|.|...:|..|...|....|.|.|.|..
  Rat  1446 GGVQERGVFCPGGLCDWTK--RP---ASTVPCNRHLCCHWATGNWELCTTSCGGGSQKRTVHCIP 1505

  Fly  1381 FQGDGVEDK---HCDAKKRPSKRRICNNCVRRQSRVISQCNCEGVEKRRDFC 1429
            .:....||:   .||.:.||.:.:.||....|:|   :...|........||
  Rat  1506 SENSTTEDQDQCFCDHQARPPEFQNCNQQACRKS---ADLTCTKDRLSTSFC 1554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep <295..394 CDD:460254 10/32 (31%)
ZnMc_ADAMTS_like 455..655 CDD:239801 78/213 (37%)
ADAMTS_CR_2 671..740 CDD:465496 28/69 (41%)
TSP1 754..806 CDD:214559 30/51 (59%)
ADAMTS_CR_3 815..911 CDD:437068 35/99 (35%)
TSP1 1172..1229 CDD:214559 25/269 (9%)
TSP1_ADAMTS 1243..1282 CDD:465950 12/41 (29%)
TSP1_ADAMTS 1355..1405 CDD:465950 15/52 (29%)
GON 1493..1687 CDD:462559
Adamts12NP_001099890.2 Pep_M12B_propep 54..197 CDD:460254 11/38 (29%)
ZnMc_ADAMTS_like 250..457 CDD:239801 79/215 (37%)
ADAMTS_CR_2 472..536 CDD:465496 28/69 (41%)
TSP1 549..600 CDD:214559 30/50 (60%)
ADAMTS_CR_3 607..705 CDD:437068 36/102 (35%)
ADAMTS_spacer1 707..816 CDD:461796 28/141 (20%)
TSP1_ADAMTS 832..886 CDD:465950 11/54 (20%)
TSP1_ADAMTS 890..944 CDD:465950 14/53 (26%)
TSP1_ADAMTS 952..1000 CDD:465950 16/50 (32%)
TSP1_ADAMTS 1321..1369 CDD:465950 15/47 (32%)
TSP1_ADAMTS 1372..1429 CDD:465950 11/56 (20%)
TSP1_ADAMTS 1432..1477 CDD:465950 9/49 (18%)
TSP1_ADAMTS 1480..1536 CDD:465950 16/55 (29%)
Blue background indicates that the domain is not in the aligned region.

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