DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts17

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_218753.6	Gene:	Adamts17 / 293004	RGDID:	1308783	Length:	1122	Species:	Rattus norvegicus

Alignment Length:	1166	Identity:	328/1166 - (28%)
Similarity:	488/1166 - (41%)	Gaps:	224/1166 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 NLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLG-----CFYSGYVE 356
            :|..|||.|:|.||:|..|:                .||.|.|........|     |||||.|.
  Rat    83 HLPAFGRDLYLQLRRDLRFL----------------SPGFEVEEAGVSGRSGHPAELCFYSGQVL 131

  Fly   357 DDPHSMVSVSLC---GGMTGYIKTSFGALLIQPVNRTSSDEVLHRVFRKSQRNARHAVSKFELGL 418
            ..|.|:||:|.|   ||:.|.|:.....:.|||:|.:...      |.:.:    |.:.:.....
  Rat   132 GHPGSLVSLSACGAAGGLVGLIQLEQELVFIQPLNNSGGP------FSRRE----HLIRRKWSST 186

  Fly   419 DDFMSKLEQVQEE-----EQKSKSRKLN---RKKRHYADVDNQVYTLEVLIAVDNSMKQFHG-ED 474
            ....:|:|..::.     |:|.:..||:   |::|:...:.|: :|:|.|:..|..|.|:|| |.
  Rat   187 SGLATKVEGPRQHCKVVTEEKPRKGKLSWDWRERRNAIRLTNE-HTVETLVVADADMVQYHGAEA 250

  Fly   475 LQPYILILMSIVSSIFADASIGNSIRILLVRLISL---PNINDQTHSSNEMLKHFCQFINQS-GY 535
            .|.:||.:|::|.::|...|:|..|.|.:.:|:.|   |......|.....|:.||.:.|:. |.
  Rat   251 AQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGG 315

  Fly   536 ER-----------------DTAMLITREPICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDTGL 582
            .|                 |.|:.:||...|.. ..:.|..:|:|.||.|||:. .|.:.:|.||
  Rat   316 ARYLGNNQVPGGKDDTPPVDAAVFVTRTDFCVH-KDEPCDTVGIAYLGGVCSAKRKCVLAEDNGL 379

  Fly   583 PTAFTMAHELGHILNMNHDDD-DKCMPYVTRQNNNKVLHIMSS--VMGIHMHPWSWSKCSRHFVS 644
            ..|||:||||||.|.|||||| ..|   ..|.      ||||.  |.|.:....|||.|||..:.
  Rat   380 NLAFTIAHELGHNLGMNHDDDHSSC---AGRS------HIMSGEWVKGRNPSDLSWSSCSRDDLE 435

  Fly   645 EFLEKTDKSCL-----ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEE--CKRLW 702
            .||:....:||     .:.....:|:   :|||..||.:.|||:.||.:..:|...|.  |..||
  Rat   436 NFLKSKVSTCLLITDPRSQHALRLPH---KLPGMHYSANEQCQILFGTNATFCKNMEHLMCAGLW 497

  Fly   703 CNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTC 767
            | ...|:::  |.:...|..|||.||:. .||:.|:||| |......|:|.|.||:.::.||.||
  Rat   498 C-LVEGDTS--CKTKLDPPLDGTECGAD-KWCRAGECVS-KTPIPEHVDGDWSPWSAWSMCSRTC 557

  Fly   768 GGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNP 832
            |.|.:..:|:|:.|.|..||.:|.|:..::.:|....||.|....|:|||.|.:..:....|:.
  Rat   558 GTGARFRQRKCDNPPPGPGGTHCQGASVEHAACENLPCPKGVPSFRDQQCQAHDRLSSKKRGLL- 621

  Fly   833 DTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAK 897
             |..|  .:...|:|:|....|.:..::...|.|||.|.....|.||.|.|:..|||..:.|.||
  Rat   622 -TAMV--VDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVYGRCQKIGCDGIIGSAAK 683

  Fly   898 LDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYYVTR--IPKGASNIIITQRGYPDQN 960
            .|:||||.|...||..|.|:...|...|            |:..  ||.||..|.:.: ..|..:
  Rat   684 EDRCGVCSGDGKTCRVVKGDFSHSRGTG------------YIEAVVIPAGARRIRVVE-DKPAHS 735

  Fly   961 FIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDV 1025
            |:.|.|. ....:|..:....|.:|..||..::|. ...:.|:.:......:...|:|.:.
  Rat   736 FLALKDS-SKRSINSDWKIELPGEFQIAGTIVRYV-RRGLWEKFSAKGPTTVPLHLMVLLF---- 794

  Fly  1026 SPSKRQDTVLLSYSYTID------------KPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPA 1078
                ......:.|.|||.            ||.|     .::.|.......|...|.|...|  .
  Rat   795 ----HDQNYGIHYEYTIPVNQSTENQSEPAKPQD-----ALFLWTHSGWEGCSVQCGGGERR--T 848

  Fly  1079 CISTTQGVK-----VAPQFCDKSAMPKIDDRACNT-DCRLNLTVTSISECSAACGELGTREKTYA 1137
            .:|.|:.|.     |....|.:::.|:...|.||: .|:........|.|||.| |.|.:.:...
  Rat   849 IVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNSHPCQSRWVAGQWSPCSATC-EKGIQHREVT 912

  Fly  1138 CV---QTFTNMQRSNIVDMSYCKLKFDVAYHEECR-EGC---WVLSEWSTCSKSCGTGSQQREAH 1195
            ||   |..|::....|    ||........ :.|. :.|   |..||||.||.:||.|.::|...
  Rat   913 CVYQLQNGTHVTTRPI----YCSEPRPTPV-QSCEGQDCLSIWEASEWSECSANCGKGIRKRTVT 972

  Fly  1196 CYLHNSRVSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEK--- 1257
            |     ..|...|:..|:|...        |:|..|:      ....|..|:|.:|:..|.|
  Rat   973 C-----TNSQGKCDAATRPKAE--------EACEDYS------GCYEWKTGDWSKCSSTCGKGLQ 1018

  Fly  1258 TRSVSCSHP----YGIGCGS-RKPKDVRKCCHIKYTSDWTDCSVQCGEGVKRKKQSCTR----VY 1313
            :|.|.|.|.    :|..|.: .||...|: ||.:..::..:.:......:......|||    ||
  Rat  1019 SRVVQCMHKVTGRHGSECPTLSKPAAYRQ-CHQEVCNEKINVNTITSPRLAALTYKCTRDQWTVY 1082

  Fly  1314 KPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKSCRINCKWNASDWRRCPADCSEEYQTR 1374
                     .||..::|.|                  .:.:|    ::||...|.:.|..:
  Rat  1083 ---------CRVIREKSLC------------------QDMRW----YQRCCQTCRDFYANK 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	35/104 (34%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	78/225 (35%)
		Reprolysin	457..655	CDD:279729	77/223 (35%)
		Salp15	<696..745	CDD:288931	20/50 (40%)
		TSP1	754..806	CDD:214559	18/51 (35%)
		ADAM_spacer1	937..1042	CDD:283607	21/106 (20%)
		TSP1	1172..1229	CDD:214559	18/59 (31%)
		GON	1495..1687	CDD:285848
Adamts17	XP_218753.6	Pep_M12B_propep	61..179	CDD:279848	37/121 (31%)
		AANH_like	168..>244	CDD:294206	16/86 (19%)
		Reprolysin	230..447	CDD:279729	79/226 (35%)
		ZnMc_ADAMTS_like	230..447	CDD:239801	79/226 (35%)
		TSP1	544..596	CDD:214559	18/51 (35%)
		ADAM_spacer1	698..808	CDD:283607	26/132 (20%)
		TSP_1	893..946	CDD:278517	15/58 (26%)
		TSP1	950..>981	CDD:214559	13/35 (37%)
		TSP1	1001..1053	CDD:214559	17/52 (33%)
		PLAC	1080..1106	CDD:285849	9/56 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11584
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820