DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AdamTS-A and Wfikkn2

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_220855.1	Gene:	Wfikkn2 / 287631	RGDID:	1305361	Length:	571	Species:	Rattus norvegicus

Alignment Length:	610	Identity:	121/610 - (19%)
Similarity:	200/610 - (32%)	Gaps:	219/610 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   830 VNPDTKWVPKYEKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGIC----------- 883
            :||:. ||.  .:..||..|..|.:               |  ::::||...:|
  Rat    45 MNPNL-WVD--AQSTCKRECETDQE---------------C--ETYEKCCPNVCGTKSCVAARYM 89

  Fly   884 ------------RPAGCDNELNSIAKLDKCGVCEGR-----NDTCHEVTGNLLVSNLLGLNDGNE 931
                        :.|.||:.: .:.:..:|.:.:|:     .|.|.:                 |
  Rat    90 DVKGKKGPVGMPKEATCDHFM-CLQQGSECDIWDGQPVCKCKDRCEK-----------------E 136

  Fly   932 PNKT-----LYYVTR-------IPKGASNIIITQRGY---------PDQNFIVLTDDRDNEL--- 972
            |:.|     |.|..|       ..||.:..::|.|.:         |.:..:..|......|
  Rat   137 PSFTCASDGLTYYNRCYMDAEACSKGVTLSVVTCRYHFTWPNTSPPPPETTVHPTTASPETLGLD 201

  Fly   973 LNGKFLKTYPLKFVYAGVTMQYTGS--SSVVEQVNTTYSWKL---SRDLIVQIISLDVSPSKRQD 1032
            :....|..:|   |:..||:..|.|  ..||.:.....:|:.   .|:.:|      :.|:..:.
  Rat   202 MAAPALLNHP---VHQSVTVGETVSFLCDVVGRPRPELTWEKQLEDRENVV------MRPNHVRG 257

  Fly  1033 TVLLSYSYTIDKPPDYEAEVEIYRWEMQAPSNCDS---LCEGRS----HRLPACISTTQGVKVAP 1090
            .|:::..          |::.||..:.|     |:   .|..|:    .|....:|..:|.:.
  Rat   258 NVVVTNI----------AQLVIYNAQPQ-----DAGIYTCTARNVAGVLRADFPLSVVRGGQA-- 305

  Fly  1091 QFCDKSAMPKIDDRACNTDCRLNLTVTSISEC-----SAACGELGTR----EKTYACVQTFTNMQ 1146
                         || .::..||.|....:||     |..|||..||    .:...|: |||
  Rat   306 -------------RA-TSESSLNGTAFPATECLKPPDSEDCGEEQTRWHFDAQANNCL-TFT--- 352

  Fly  1147 RSNIVDMSYCKLKFDVAYHEECREGCWVL---SEWSTCSKSCGTGSQQREAHCYLHNSRVSDDLC 1208
                  ..:|....:   |.|..|.|.:.   ...:|||.....|..:.....:.:||:..  ||
  Rat   353 ------FGHCHRNLN---HFETYEACMLACMSGPLATCSLPALQGPCKAYVPRWAYNSQTG--LC 406

  Fly  1209 NPRTKPHLNTLIGICN------------TESCPTYTKSPNALAV------------SNWVI-GEW 1248
            .       :.:.|.|.            .||||....:.|..|.            |::|| |..
  Rat   407 Q-------SFVYGGCEGNGNNFESREACEESCPFPRGNQNCRACKPRQKLVTSFCRSDFVILGRV 464

  Fly  1249 GECNEWCEKTRS------VSCSHPYGIGCGSRKPKDVRKCCHIKYTSDWT-DC-SVQCGEG---V 1302
            .|..|..:..|:      |......|:....|:|.:| ...|:    ||| .| :|..||.   :
  Rat   465 SELTEEPDSGRALVTVDEVLKDEKMGLKFLGREPLEV-TLLHV----DWTCPCPNVTVGETPLII 524

  Fly  1303 KRKKQSCTRVYKPD--VPGTRKRRV 1325
            ..:.:....:.|||  |..:..|||
  Rat   525 MGEVEGGMAMLKPDSFVGASSTRRV 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848
		ZnMc_ADAMTS_like	455..655	CDD:239801
		Reprolysin	457..655	CDD:279729
		Salp15	<696..745	CDD:288931
		TSP1	754..806	CDD:214559
		ADAM_spacer1	937..1042	CDD:283607	23/128 (18%)
		TSP1	1172..1229	CDD:214559	13/71 (18%)
		GON	1495..1687	CDD:285848
Wfikkn2	XP_220855.1	WAP	37..86	CDD:395047	12/60 (20%)
		KAZAL_FS	133..169	CDD:238052	9/52 (17%)
		IgI_3_WFIKKN-like	205..299	CDD:409422	22/117 (19%)
		Ig strand B	222..226	CDD:409422	1/3 (33%)
		Ig strand C	235..239	CDD:409422	0/3 (0%)
		Ig strand E	257..261	CDD:409422	1/3 (33%)
		Ig strand F	279..284	CDD:409422	1/4 (25%)
		Ig strand G	292..295	CDD:409422	1/2 (50%)
		Kunitz_BPTI	323..374	CDD:394972	16/63 (25%)
		Kunitz_BPTI	380..431	CDD:394972	11/59 (19%)
		NTR_WFIKKN	450..558	CDD:239630	27/105 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900