DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts4

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_766433.2	Gene:	Adamts4 / 240913	MGIID:	1339949	Length:	833	Species:	Mus musculus

Alignment Length:	795	Identity:	262/795 - (32%)
Similarity:	386/795 - (48%)	Gaps:	117/795 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 YNLNVFGRQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPH 360
            |.|..||..|.|.|.||.. |....:| ::.|.:     .||....||.   |.:.:|.:..||.
Mouse    79 YRLPAFGEMLLLELEQDPG-VQVEGLT-VQYLGQ-----APEMLGGAEP---GTYLTGTINGDPE 133

  Fly   361 SMVSVSLCGG-MTGYIKTSFGALLIQPVN----RTSSDEVLHRVFRKSQRNARHAVSKFELGLDD 420
            |:.|:...|| :.|.::.....|.:||:.    .::.....|.:.|||..:::..:...
Mouse   134 SVASLHWDGGALLGVLQYRGAELHLQPLEGGALNSAGGPGAHILRRKSPASSQGPMCTV------ 192

  Fly   421 FMSKLEQVQEEEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSI 485
                      :........::|:.:.:|.:...|   |.|:..|:.|..|||..|:.|:|.:|:.
Mouse   193 ----------KAPSGSPSPISRRTKRFASLSRFV---ETLVVADDKMAAFHGTGLKRYLLTVMAA 244

  Fly   486 VSSIFADASIGNSIRILLVRLISL------PNINDQTHSSNEMLKHFCQFINQSGYER------- 537
            .:..|...||.|.:.:::.||:.|      |.:..   |:.:.|:.||.:  |.|...
Mouse   245 AAKAFKHPSIRNPVNLVVTRLVILGSGQEGPQVGP---SAAQTLRSFCTW--QRGLNTPNDSDPD 304

  Fly   538 --DTAMLITREPICGSVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMN 599
              |||:|.||:.:||.   ..|..||:|::||||. :.||:||:|.||.:|||.||||||:.||.
Mouse   305 HFDTAILFTRQDLCGV---STCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML 366

  Fly   600 HDDDDKCMPYVTRQNNNKVLHIMSSVMGIHMHPWS-WSKCSRHFVSEFLEKTDKSCL--ETSVGA 661
            ||:...|.....:..:::  |:|:.||. |:.|.. ||.||..|:::||:.....||  :.....
Mouse   367 HDNSKPCTNLNGQGGSSR--HVMAPVMA-HVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPL 428

  Fly   662 HIPYGTERLPGEIYSLDAQCQLSFGNDFGYCP-TDEECKRLWCNRTSG--NSNEQCASSNLPWAD 723
            |:|   ...||:.|..|.||||:||.|..:|| ....|..|||   ||  |.:..|.:.:.||||
Mouse   429 HLP---ATFPGKDYDADRQCQLTFGPDSSHCPQLPPPCAALWC---SGHLNGHAMCQTKHSPWAD 487

  Fly   724 GTPCGSSGHWCQRGKC--VSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENG 786
            ||||||| ..|..|:|  |.....:.....||||||.|:..||.|||||||.|.|:|.:|||.||
Mouse   488 GTPCGSS-QACMGGRCLHVDQLKDFNVPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNG 551

  Fly   787 GKYCTGSRKKYRSCNTHQCPPGS-MDPREQQCYAMNGRN---MNIPGVNPDTKWVPKY----EKD 843
            ||||.|.|.::|||||..||.|| :..||:||.|.|.|.   .:.||   ...|||:|    .:|
Mouse   552 GKYCEGRRTRFRSCNTENCPHGSALTFREEQCAAYNHRTDLFKSFPG---PMDWVPRYTGVAPRD 613

  Fly   844 ACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRN 908
            .|||.|:......|::|:..|.|||.|:.|:...||.|.|..||||..:.|..|.|||.||.|..
Mouse   614 QCKLTCQARALGYYYVLEPRVADGTPCSPDTSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDG 678

  Fly   909 DTCHEVTGNLLVSNLLGLNDGNEPNKTLYY----VTRIPKGASNIIITQRGYPDQN--FIVLTDD 967
            ..|.:.:|:.               |...|    |..||.||::|::.|:|.....  ::.|...
Mouse   679 SRCSKQSGSF---------------KKFRYGYSDVVTIPAGATHILVRQQGGSGLKSIYLALKLS 728

  Fly   968 RDNELLNGKF-LKTYPLKFVYAG-VTMQYTGSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKR 1030
            ..:..|||:: |...|...|..| |:::|:|:::..|.::       ....:.|.::|.|..:..
Mouse   729 DGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLS-------GHGPLAQPLTLQVLVAGN 786

  Fly  1031 QDTVLLSYSYTIDKP 1045
            .....|.||:.:.:|
Mouse   787 PQNARLRYSFFVPRP 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	28/102 (27%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	75/216 (35%)
		Reprolysin	457..655	CDD:279729	75/214 (35%)
		Salp15	<696..745	CDD:288931	23/52 (44%)
		TSP1	754..806	CDD:214559	33/51 (65%)
		ADAM_spacer1	937..1042	CDD:283607	27/112 (24%)
		TSP1	1172..1229	CDD:214559
		GON	1495..1687	CDD:285848
Adamts4	NP_766433.2	Pep_M12B_propep	74..177	CDD:279848	29/107 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..204		2/39 (5%)
		Cysteine switch. /evidence=ECO:0000250	188..195		0/22 (0%)
		Reprolysin	214..424	CDD:279729	78/223 (35%)
		ZnMc_ADAMTS_like	214..421	CDD:239801	77/220 (35%)
		ADAM_CR	434..505	CDD:301627	35/74 (47%)
		ADAM_CR	486..655	CDD:301627	82/172 (48%)
		TSP1	527..571	CDD:214559	28/43 (65%)
		Spacer	682..833		30/142 (21%)
		ADAM_spacer1	683..798	CDD:283607	29/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910