DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts19

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	XP_006525982.1	Gene:	Adamts19 / 240322	MGIID:	2442875	Length:	1234	Species:	Mus musculus

Alignment Length:	1204	Identity:	319/1204 - (26%)
Similarity:	503/1204 - (41%)	Gaps:	264/1204 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 RQLHLVLRQDASFVHNHSMTHIRILKEGEEHPGPE-TEAEAEQ-----RHLGCFYSGYVEDDPHS 361
            |.|:|:||:|..|:..      |...|....|||: |.|.|:.     ....|||:|.|...|.|
Mouse   177 RDLYLLLRRDGRFLAQ------RFAVEQWPKPGPDPTRATADPGSSLLPDASCFYTGTVLRHPGS 235

  Fly   362 MVSVSLC-GGMTGYIKTSFGALLIQPVNRTSSDEVL---HRVFRKSQR-----NARHAVSKFELG 417
            :.|.|.| ||:.|:|:.:...|.|:|.|.|.:  ::   ||::|:.:.     ....||.:...|
Mouse   236 LASFSTCGGGLMGFIQLNEDFLFIEPFNDTMA--IIGHPHRLYRQKRSTEEKVTENSAVHRHHCG 298

  Fly   418 LDDFMSKLEQVQEEEQKSKSRKL--NRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGED-LQPYI 479
                      |..::.:.:|:|:  ||:::.|:...:|.|.:|.::..|.:|..:||.| .:.:|
Mouse   299 ----------VISDKGRPRSKKIADNRREKRYSYKLSQEYNIETVVVADPAMVSYHGADAARRFI 353

  Fly   480 LILMSIVSSIFADASIGNSIRILLVRLISLPNINDQT-------HSSNEMLKHFCQFINQSGYER 537
            |.::::|.::|...|:|..:.:.:::||.|    .:|       |...:||:.||::.::....|
Mouse   354 LTILNMVFNLFQHKSLGVQVNLRVLKLILL----HETPADLYIGHHGEKMLESFCKWQHEEFGRR 414

  Fly   538 ------------------DTAMLITREPICGSVPGKICHMLGLAELGTVCSSS-SCSIVQDTGLP 583
                              |.|:||||:..|.. ..:.|..:|:|.|..:||.. .|.|.:|.||.
Mouse   415 NDVHLEMSTSWGEDIAAVDAAILITRKDFCVH-KDEPCDTVGIAYLNGMCSEKRKCIIAEDNGLN 478

  Fly   584 TAFTMAHELGHILNMNHDDD-DKCMPYVTRQNNNKVLHIMSS--VMGIHMHPWSWSKCSRHFVSE 645
            .|||:|||:||.:.:|||:| ..|.         ..|||||.  :.|.::...|||:||:..:..
Mouse   479 LAFTIAHEMGHNMGINHDNDHPSCA---------DGLHIMSGEWIKGQNLGDVSWSRCSKEDLER 534

  Fly   646 FLEKTDKSCL-----ETSVGAHIPYGTERLPGEIYSLDAQCQLSFGNDFGYCPTDEE--CKRLWC 703
            ||.....|||     ::.....:|   .:|||..|:.|.|||:.||....:|...:.  |..|||
Mouse   535 FLRSKASSCLLHTDPQSLSSVLVP---SKLPGMAYTADEQCQILFGPLASFCQEMQHVICTGLWC 596

  Fly   704 NRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCG 768
             :..|.:  :|.:...|..|||.| ..|.||:.|:| :.:......:.|.|.||   :.||.:|.
Mouse   597 -KVEGEA--ECRTKLDPPMDGTDC-DPGKWCKAGEC-TRRTPAPEHLAGEWSPW---SSCSRSCS 653

  Fly   769 GGVQESRRECNQPVPENGGKYCTGSRKKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPD 833
            .||....|:|  |...:..:.|.|.||:||.|....||.|....|:.||.|.:.|..
Mouse   654 SGVSSRERKC--PGLGSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTS-------- 708

  Fly   834 TKWVPKY---------EKDACKLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCD 889
               .||:         |:..|.|||....|....:|...|.|||||.....|.|.||.|:.||||
Mouse   709 ---YPKHALQWQAVFDEEKPCALFCSPVGKEQPVLLSEKVMDGTSCGYQGLDICANGRCQKAGCD 770

  Fly   890 NELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLYY-VTRIPKGASNIIITQ 953
            ..|.|:|:.|.||||.|...:|..:.|           |.|......|. |..||.||..|.:.:
Mouse   771 GLLGSLAREDHCGVCNGNGKSCKVIKG-----------DFNHTRGAGYVEVLVIPAGARRIKVVE 824

  Fly   954 RGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTGSSSVVEQVNTTYSWKLSRDLIV 1018
            . .|..:|:.|. |...:.:|..:...:...|..||.|:.|. ...:.|:::..........|:|
Mouse   825 E-KPAHSFLALR-DASKQSINSDWKIEHSGAFSLAGTTVHYL-RRGLWEKISAKGPTTTPLHLLV 886

  Fly  1019 QIISLDVSPSKRQDTVLLSYSYTI--DKPPDYEAEVE---IYRWEMQAPSNCDSLCEGRSHR-LP 1077
            .:.        :.....|.|.||:  |..||.::..|   ::.|......:|::.|.|...: :.
Mouse   887 LLF--------QDQNYGLHYEYTVPSDPLPDNQSSKEPGPLFMWTHAGWGDCNATCGGGERKTMV 943

  Fly  1078 AC-------ISTTQGVKVAPQFCDKSAMPKIDDRACNTD-CRLNLTVTSISECSAACGELGTREK 1134
            :|       ||.....|     |.....|:...|.||.. |:           ::.||.:.|..:
Mouse   944 SCTKIMSKNISLVDNKK-----CKDLTKPEPQIRKCNEQPCQ-----------TSPCGTVTTLRQ 992

  Fly  1135 TYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTCSKSCGTGSQQREAHC--Y 1197
            | .|.|.:.:::.:.                       |:::||:|||::||.|.|.|:..|  .
Mouse   993 T-VCHQLYISVRFTR-----------------------WMMTEWTTCSRTCGKGVQSRQVACTQQ 1033

  Fly  1198 LHNSRV----SDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCEK- 1257
            |.|..:    ..|...|  ||   ..:..|..:.|.|.           |..|.|.||:..|.|
Mouse  1034 LENGTLIRAWERDCLGP--KP---ATVQRCEGQDCMTV-----------WEAGVWSECSVKCGKG 1082

  Fly  1258 --TRSVSCSHPYGIGCGSRKPKDVRKC-----CHIKYTSDWTDCSVQCGEGVKRKKQSCTRVYKP 1315
              .|:|.|::|......|.:|::...|     |::....||:.||:.||:|::.:...|  ::|
Mouse  1083 VRHRTVRCTNPRKKCVLSTRPREAEDCEDYSKCYVWRVGDWSKCSITCGKGMQSRVIQC--MHK- 1144

  Fly  1316 DVPGTRKRRVYVDESYCISRKVH--------------RPKLRTTTKSCRINCKWNASDWRRCPAD 1366
             :.|......:..|.....|..|              .|:|...|..| :..:|        |..
Mouse  1145 -ITGRHGNECFSSEKPAAYRPCHLQPCNEKINVNTITSPRLAALTFKC-LGDQW--------PVY 1199

  Fly  1367 C---SEEYQTRDVR--------CESFQGDGVEDK 1389
            |   .|:...:|:|        |..|....::.|
Mouse  1200 CRVIREKNLCQDMRWYQRCCETCRDFYAQKLQQK 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	34/97 (35%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	68/229 (30%)
		Reprolysin	457..655	CDD:279729	67/227 (30%)
		Salp15	<696..745	CDD:288931	16/50 (32%)
		TSP1	754..806	CDD:214559	18/51 (35%)
		ADAM_spacer1	937..1042	CDD:283607	23/105 (22%)
		TSP1	1172..1229	CDD:214559	19/62 (31%)
		GON	1495..1687	CDD:285848
Adamts19	XP_006525982.1	Pep_M12B_propep	161..276	CDD:366707	36/106 (34%)
		ZnMc_ADAMTS_like	328..545	CDD:239801	69/230 (30%)
		ADAM_CR_2	562..629	CDD:375321	26/71 (37%)
		ADAM_spacer1	793..903	CDD:368694	27/131 (21%)
		TSP1	1010..1063	CDD:214559	18/57 (32%)
		TSP1	1066..1111	CDD:214559	14/55 (25%)
		TSP1	1115..1170	CDD:214559	14/58 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820