DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AdamTS-A and Adamts5

DIOPT Version :9

Sequence 1:	NP_996218.1	Gene:	AdamTS-A / 41887	FlyBaseID:	FBgn0286071	Length:	1688	Species:	Drosophila melanogaster
Sequence 2:	NP_035912.2	Gene:	Adamts5 / 23794	MGIID:	1346321	Length:	930	Species:	Mus musculus

Alignment Length:	942	Identity:	273/942 - (28%)
Similarity:	394/942 - (41%)	Gaps:	234/942 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 AEQRHLG-CFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTS-----------SDE 394
            |...|.| |||.|.|:..|.|:....||||:.|:.........::|:.|.|           |..
Mouse   124 ASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGSWAEYERIYGDGSSR 188

  Fly   395 VLHRVFRK-----------------------------SQRNARHAVSKFELGLDDFMSKLEQVQE 430
            :||...|:                             |:...|.|::...|....|........:
Mouse   189 ILHVYNREGFSFEALPPRASCETPASPSGPQESPSVHSRSRRRSALAPQLLDHSAFSPSGNAGPQ 253

  Fly   431 EEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASI 495
            ...:.:.|.::|.::           :|:|:..|:||.:.:|..||.|:|.|.||.:.:::.|||
Mouse   254 TWWRRRRRSISRARQ-----------VELLLVADSSMARMYGRGLQHYLLTLASIANRLYSHASI 307

  Fly   496 GNSIRILLVRLISLPNINDQTHSSNE---MLKHFCQF---INQSGYER----DTAMLITREPICG 550
            .|.||:.:|:::.|.:.:.....|..   .||:||::   .||.|.:.    |.|:|.|||.:||
Mouse   308 ENHIRLAVVKVVVLTDKDTSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCG 372

  Fly   551 SVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMP-YVTRQ 613
            .   ..|..||:|::||:|| ..||::::|.||..|||:|||:||:|.::|||...|.. :.|.:
Mouse   373 H---HSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGTTE 434

  Fly   614 NNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIP----YGTERLPGEI 674
            :.    .:|||::........||||:...::|||:....:||     ..:|    .|.|.|||:.
Mouse   435 DK----RLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCL-----LDLPRKQILGPEELPGQT 490

  Fly   675 YSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKC 739
            |....||.|:||.::..||..:.|.|||| .........|.:..||..:||||| .|..|.:|||
Mouse   491 YDATQQCNLTFGPEYSVCPGMDVCARLWC-AVVRQGQMVCLTKKLPAVEGTPCG-KGRVCLQGKC 553

  Fly   740 V--SNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNT 802
            |  :.|..|....:|.||.|.|:..||.:||||||.:.|.||.|.|.|.|:||||.|..||||:.
Mouse   554 VDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSGRYCTGKRAIYRSCSV 618

  Fly   803 HQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKSM 863
            ..|||.....|.:||.|.||...:..||....:|||||    ..|.|||.||......|.:....
Mouse   619 TPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPK 683

  Fly   864 VTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLND 928
            |||||.|...|...||.|.|...|||..:.|..:.||||||.|.|.:|.::.|..
Mouse   684 VTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIIGTF---------- 738

  Fly   929 GNEPNKTLYYVTRIPKGASNIIITQRGYPDQN----FIVLTDDRDNELLNGKF-LKTYPLKFVYA 988
             |:.:|....|.|||:||::|.:.|....||.    ::.|.......|:|||: :.|........
Mouse   739 -NKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGEYLINGKYMISTSETIIDIN 802

  Fly   989 GVTMQYTGSS-----------SVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI 1042
            |..|.|:|.|           |..:::           |||||::.|  |:|..|   :.||:.:
Mouse   803 GTVMNYSGWSHRDDFLHGMGYSATKEI-----------LIVQILATD--PTKALD---VRYSFFV 851

  Fly  1043 DKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACN 1107
            .|                                    .|||.|.
Mouse   852 PK------------------------------------KTTQKVN-------------------- 860

  Fly  1108 TDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGC 1172
                        |..|....::|...         |.:|
Mouse   861 ------------SVISHGSNKVGPHS---------TQLQ-------------------------- 878

  Fly  1173 WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVS 1204
            ||...|..||::|.||...|...|...|.:::
Mouse   879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLA 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AdamTS-A	NP_996218.1	Pep_M12B_propep	286..394	CDD:279848	19/63 (30%)
		ZnMc_ADAMTS_like	455..655	CDD:239801	74/211 (35%)
		Reprolysin	457..655	CDD:279729	74/209 (35%)
		Salp15	<696..745	CDD:288931	20/50 (40%)
		TSP1	754..806	CDD:214559	28/51 (55%)
		ADAM_spacer1	937..1042	CDD:283607	33/120 (28%)
		TSP1	1172..1229	CDD:214559	11/33 (33%)
		GON	1495..1687	CDD:285848
Adamts5	NP_035912.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..68
		Pep_M12B_propep	68..174	CDD:279848	17/49 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..231		1/23 (4%)
		Cysteine switch. /evidence=ECO:0000250	207..214		0/6 (0%)
		Reprolysin	269..476	CDD:279729	76/218 (35%)
		ZnMc_ADAMTS_like	269..473	CDD:239801	76/215 (35%)
		ADAM_CR	486..556	CDD:301627	30/71 (42%)
		TSP1	570..622	CDD:214559	28/51 (55%)
		Spacer	732..874		44/236 (19%)
		ADAM_spacer1	732..852	CDD:283607	36/146 (25%)
		TSP1	879..930	CDD:214559	11/32 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10804
eggNOG	1	0.900	-	-		E1_KOG3538
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125522at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100241
Panther	1	1.100	-	-	O	PTHR13723
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820