DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Adamts5

DIOPT Version :10

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_035912.2 Gene:Adamts5 / 23794 MGIID:1346321 Length:930 Species:Mus musculus


Alignment Length:942 Identity:273/942 - (28%)
Similarity:394/942 - (41%) Gaps:234/942 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 AEQRHLG-CFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALLIQPVNRTS-----------SDE 394
            |...|.| |||.|.|:..|.|:....||||:.|:.........::|:.|.|           |..
Mouse   124 ASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGSWAEYERIYGDGSSR 188

  Fly   395 VLHRVFRK-----------------------------SQRNARHAVSKFELGLDDFMSKLEQVQE 430
            :||...|:                             |:...|.|::...|....|........:
Mouse   189 ILHVYNREGFSFEALPPRASCETPASPSGPQESPSVHSRSRRRSALAPQLLDHSAFSPSGNAGPQ 253

  Fly   431 EEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASI 495
            ...:.:.|.::|.::           :|:|:..|:||.:.:|..||.|:|.|.||.:.:::.|||
Mouse   254 TWWRRRRRSISRARQ-----------VELLLVADSSMARMYGRGLQHYLLTLASIANRLYSHASI 307

  Fly   496 GNSIRILLVRLISLPNINDQTHSSNE---MLKHFCQF---INQSGYER----DTAMLITREPICG 550
            .|.||:.:|:::.|.:.:.....|..   .||:||::   .||.|.:.    |.|:|.|||.:||
Mouse   308 ENHIRLAVVKVVVLTDKDTSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCG 372

  Fly   551 SVPGKICHMLGLAELGTVCS-SSSCSIVQDTGLPTAFTMAHELGHILNMNHDDDDKCMP-YVTRQ 613
            .   ..|..||:|::||:|| ..||::::|.||..|||:|||:||:|.::|||...|.. :.|.:
Mouse   373 H---HSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGTTE 434

  Fly   614 NNNKVLHIMSSVMGIHMHPWSWSKCSRHFVSEFLEKTDKSCLETSVGAHIP----YGTERLPGEI 674
            :.    .:|||::........||||:...::|||:....:||     ..:|    .|.|.|||:.
Mouse   435 DK----RLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCL-----LDLPRKQILGPEELPGQT 490

  Fly   675 YSLDAQCQLSFGNDFGYCPTDEECKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHWCQRGKC 739
            |....||.|:||.::..||..:.|.|||| .........|.:..||..:||||| .|..|.:|||
Mouse   491 YDATQQCNLTFGPEYSVCPGMDVCARLWC-AVVRQGQMVCLTKKLPAVEGTPCG-KGRVCLQGKC 553

  Fly   740 V--SNKHGYGRQVNGGWGPWTPFTPCSLTCGGGVQESRRECNQPVPENGGKYCTGSRKKYRSCNT 802
            |  :.|..|....:|.||.|.|:..||.:||||||.:.|.||.|.|.|.|:||||.|..||||:.
Mouse   554 VDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSGRYCTGKRAIYRSCSV 618

  Fly   803 HQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKWVPKY----EKDACKLFCRMDMKVTYFMLKSM 863
            ..|||.....|.:||.|.||...:..||....:|||||    ..|.|||.||......|.:....
Mouse   619 TPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPK 683

  Fly   864 VTDGTSCAVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLND 928
            |||||.|...|...||.|.|...|||..:.|..:.||||||.|.|.:|.::.|..          
Mouse   684 VTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIIGTF---------- 738

  Fly   929 GNEPNKTLYYVTRIPKGASNIIITQRGYPDQN----FIVLTDDRDNELLNGKF-LKTYPLKFVYA 988
             |:.:|....|.|||:||::|.:.|....||.    ::.|.......|:|||: :.|........
Mouse   739 -NKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGEYLINGKYMISTSETIIDIN 802

  Fly   989 GVTMQYTGSS-----------SVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTI 1042
            |..|.|:|.|           |..:::           |||||::.|  |:|..|   :.||:.:
Mouse   803 GTVMNYSGWSHRDDFLHGMGYSATKEI-----------LIVQILATD--PTKALD---VRYSFFV 851

  Fly  1043 DKPPDYEAEVEIYRWEMQAPSNCDSLCEGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACN 1107
            .|                                    .|||.|.                    
Mouse   852 PK------------------------------------KTTQKVN-------------------- 860

  Fly  1108 TDCRLNLTVTSISECSAACGELGTREKTYACVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGC 1172
                        |..|....::|...         |.:|                          
Mouse   861 ------------SVISHGSNKVGPHS---------TQLQ-------------------------- 878

  Fly  1173 WVLSEWSTCSKSCGTGSQQREAHCYLHNSRVS 1204
            ||...|..||::|.||...|...|...|.:::
Mouse   879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLA 910

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep <295..394 CDD:460254 19/63 (30%)
ZnMc_ADAMTS_like 455..655 CDD:239801 74/211 (35%)
ADAMTS_CR_2 671..740 CDD:465496 27/68 (40%)
TSP1 754..806 CDD:214559 28/51 (55%)
ADAMTS_CR_3 815..911 CDD:437068 42/99 (42%)
TSP1 1172..1229 CDD:214559 11/33 (33%)
TSP1_ADAMTS 1243..1282 CDD:465950
TSP1_ADAMTS 1355..1405 CDD:465950
GON 1493..1687 CDD:462559
Adamts5NP_035912.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..68
Pep_M12B_propep 68..182 CDD:460254 18/57 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 207..231 1/23 (4%)
Cysteine switch. /evidence=ECO:0000250 207..214 0/6 (0%)
ZnMc_ADAMTS_like 269..473 CDD:239801 76/215 (35%)
ADAMTS_CR_2 487..554 CDD:465496 27/68 (40%)
TSP1 570..622 CDD:214559 28/51 (55%)
ADAMTS_CR_3 628..731 CDD:437068 43/102 (42%)
Spacer 732..874 44/236 (19%)
ADAMTS_spacer1 733..852 CDD:461796 36/145 (25%)
TSP1_ADAMTS 879..930 CDD:465950 11/32 (34%)
Blue background indicates that the domain is not in the aligned region.

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