DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Adamtsl4

DIOPT Version :10

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:NP_659148.2 Gene:Adamtsl4 / 229595 MGIID:2389008 Length:1036 Species:Mus musculus


Alignment Length:892 Identity:217/892 - (24%)
Similarity:299/892 - (33%) Gaps:239/892 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   716 SSNLPWADGTPCGSSGHWCQRGKCVSNKHGYGRQVNGGWGPWTPFTPCSLTCGGGV--------- 771
            :|:.|...|||..:|            ..|..|...|..||..|.:|.|.:...|.         
Mouse   229 TSSAPSYTGTPAPTS------------SFGDSRSFQGSLGPRMPPSPGSWSSPQGAERRHPPPFS 281

  Fly   772 -----QESRRECNQPVPENG-----------------------GKYCTGSRKKYRSCNTHQCPPG 808
                 |:|||....|.|...                       ...|:|..::.|:|:...|||.
Mouse   282 PVPRSQQSRRHWRPPGPHRSPDGWLPLTRDSSPLWSIFAPSIPAPNCSGESEQMRACSQEPCPPE 346

  Fly   809 SMDPREQQCYAMNGRNMNIPGVNPDTKWVPKYE---KDACKLFCRMDMKVTYFMLKSMVTDGTSC 870
            ..|||..||.|.:.:..    :....:|.|..|   ...|:|.||......|......|.|||.|
Mouse   347 QPDPRALQCAAFDSQEF----MGQLYQWEPFTEVQGSQRCELNCRPRGFRFYVRHTEKVQDGTLC 407

  Fly   871 AVDSFDKCVNGICRPAGCDNELNSIAKLDKCGVCEGRNDTCHEVTGNLLVSNLLGLNDGNEP--- 932
            ...|.|.||.|.|...|||..|.|..:.|.||||.|...||..|:||        |.|...|   
Mouse   408 QPGSLDICVAGRCLSPGCDGVLGSGRRPDGCGVCGGDGSTCRLVSGN--------LTDRGGPLGY 464

  Fly   933 NKTLYYVTRIPKGASNIIITQRGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYT-- 995
            .|.|:    ||.|||::.|:|. .|..|::.|.......::||.:....|..:...|...||.  
Mouse   465 QKILW----IPAGASHLHISQL-RPSSNYLALRGPGGRSIINGNWAVDPPGSYTAIGTVFQYNRP 524

  Fly   996 ------GSSSVVEQVNTTYSWKLSRDLIVQIISLDVSPSKRQDTVLLSYSYTID----------- 1043
                  |.|...|...|.              .:||....::|...:.|.|.|.           
Mouse   525 PREEGKGESLSAEGPTTQ--------------PVDVYMIFQEDNPGVFYQYVISSPPAVLESPST 575

  Fly  1044 KPPDYEAEVEIYR-------------------------------------------WEMQAPSNC 1065
            |||..:.:.|:.|                                           |:....|.|
Mouse   576 KPPALQPQPEMLRGEPLLPSAPRPVRAPGTLQRQVRIPQVPPPTRVRTAMGSSAGYWKQVGHSEC 640

  Fly  1066 DSLC-EGRSHRLPACISTTQGVKVAPQFCDKSAMPKIDDRACN-TDCRLNLTVTSISECSAACGE 1128
            .:.| :|..|.:..|||...|.::..|.|...|.|......|: ..|.........:.||.:||.
Mouse   641 SASCGKGVWHPIFLCISRESGEELDEQSCAVGARPPASPEPCHGPPCPPYWEAGEWTSCSRSCGP 705

  Fly  1129 LGTREKTYACVQTF------------TNMQRSNIVDMSYCKLKFDVAYHEECREGCW-VLSEWST 1180
             ||:.:...|.|.|            .::.|.||...  |:|..       |  |.| :.|.||.
Mouse   706 -GTQHRQLLCRQEFGGGGSSVPPERCGHLPRPNITQP--CQLHL-------C--GHWEISSPWSQ 758

  Fly  1181 CSKSCGTGSQQREAHCYLHN-SRVSDDLC--NPRTKPHLNTLIGICNTESCPTYTKSPNALAVSN 1242
            ||..||.|.:.|:..|...| ..|....|  .|...|....    |:...|.|           .
Mouse   759 CSVRCGRGQRSRQVRCVGSNGDEVDKQECASGPPPPPSREA----CDMGPCTT-----------A 808

  Fly  1243 WVIGEW-GECNEWCE---KTRSVSC--------SHPYG----IGCGSR-KPKDVRKC----CHIK 1286
            |...:| .:|:..|.   :.|:|.|        ..|..    .||..| :|.|:|.|    |...
Mouse   809 WFYSDWSSKCSAECGTGIQRRAVVCLRSGETLQGDPEAGSTEQGCPLRSRPPDMRACSLGPCERT 873

  Fly  1287 ---YTSDWTDCSVQCGEGVKRKKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRTTTKS 1348
               :|..|::||.:||.|.:.:...|......:...|       ..|.|  ..:.||......:.
Mouse   874 WRWFTGPWSECSSECGSGTQHRDIICVSKLGAEFNVT-------SPSNC--SHLPRPPALQPCQG 929

  Fly  1349 CRINCKWNASDWRRCPADCSEEYQTRDVRCESFQGDGVEDKHCDAKKRPSKRRICNN--CVRRQS 1411
            .....||.::.|..|...|....|||:|:|.|  |:......|....|||::|.||:  |.:|..
Mouse   930 QACEDKWFSTLWSPCSRSCQGGMQTREVQCLS--GNQTLSSRCPPHLRPSRKRPCNSQPCNQRPD 992

  Fly  1412 RVISQC-----NCEGVEKRRDFCFNSHKGRIACPTRARVERHSCTPP 1453
               .||     :|..|.:.| .|...:.....|.:.|.|...|...|
Mouse   993 ---DQCKDSSPHCPLVVQAR-LCVYPYYTTTCCRSCAHVLEQSQLEP 1035

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep <295..394 CDD:460254
ZnMc_ADAMTS_like 455..655 CDD:239801
ADAMTS_CR_2 671..740 CDD:465496 6/23 (26%)
TSP1 754..806 CDD:214559 16/88 (18%)
ADAMTS_CR_3 815..911 CDD:437068 33/98 (34%)
TSP1 1172..1229 CDD:214559 17/60 (28%)
TSP1_ADAMTS 1243..1282 CDD:465950 14/55 (25%)
TSP1_ADAMTS 1355..1405 CDD:465950 17/49 (35%)
GON 1493..1687 CDD:462559
Adamtsl4NP_659148.2 TSP1 46..>70 CDD:214559
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 73..149
PHA03247 <161..360 CDD:223021 34/142 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..308 21/90 (23%)
ADAMTS_CR_3 354..448 CDD:437068 33/97 (34%)
ADAMTS_spacer1 450..563 CDD:461796 33/139 (24%)
TSP1_ADAMTS 638..687 CDD:465950 14/48 (29%)
TSP1_ADAMTS 691..747 CDD:465950 14/65 (22%)
TSP1_ADAMTS 755..805 CDD:465950 15/53 (28%)
TSP1_ADAMTS 809..870 CDD:465950 15/60 (25%)
TSP1_ADAMTS 876..932 CDD:465950 13/64 (20%)
TSP1_ADAMTS 936..987 CDD:465950 18/52 (35%)
PLAC 995..1024 CDD:462560 6/29 (21%)
Blue background indicates that the domain is not in the aligned region.

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