DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Thsd7b

DIOPT Version :10

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_011246266.1 Gene:Thsd7b / 210417 MGIID:2443925 Length:1609 Species:Mus musculus


Alignment Length:1681 Identity:324/1681 - (19%)
Similarity:499/1681 - (29%) Gaps:628/1681 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 CHKYIQKMSTHWRQNACLYAC---CIAFLLGMLIMFHLGLRSAHKGQEELPQSTHP--------- 197
            |..:..:..|   :.|||..|   |:.                   .|..|.||.|         
Mouse   159 CEHFAPQPPT---EQACLIPCPRDCVV-------------------SEFSPWSTCPEGCGKKLQH 201

  Fly   198 ---LANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAFVMPTKVYNYS------LSEA 253
               :|.:||.......|...:   |...|.|... .|.:||:|   ...||..:|      |.|.
Mouse   202 RTRVAIAPPLYGGLQCPNLTE---SRACEAPVSC-PLGKEEYS---FSLKVGPWSKCRLPHLKEV 259

  Fly   254 DLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHN 318
            ||   |.||  |..|..:|.....:|             |..|.                  .|:
Mouse   260 DL---SGRN--IQDFSSDSNEQVTLT-------------HQSYK------------------AHH 288

  Fly   319 HSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALL 383
            ||            .|| :.....:.|.:.|..|    |..:::  :|||      ::.|| .|.
Mouse   289 HS------------QPG-DVVIGFQTRQVWCTRS----DGRNAL--LSLC------VRDSF-PLT 327

  Fly   384 IQ-----------------PVNRTSSDEVLHRVFRKSQRNARH-AVSKFELGLDDFMSKLEQVQE 430
            :|                 |.::|.....|....|...||.:| |:.    |..:....||:   
Mouse   328 VQPCVMPKDCETSEWSPWSPCSKTCRSGTLSPGVRSRSRNVKHIAIG----GGQECPELLEK--- 385

  Fly   431 EEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASI 495
                                       |..||        .||.|||                  
Mouse   386 ---------------------------ETCIA--------EGEFLQP------------------ 397

  Fly   496 GNSIRILLVRLISLPNINDQTHSSNEMLKHFCQFINQSGYERDTAMLITRE--------PICGSV 552
                         .|..:.:|....|     ||          .::|:.:.        ||||. 
Mouse   398 -------------CPRYSWRTSEWKE-----CQ----------VSLLLEQHDPLWHETGPICGG- 433

  Fly   553 PGKICHMLGLAELGTVCSSS----SCSIVQDTGLPTAFTM----AHELGHILNMNHDDDDKCMPY 609
                    |:......|:.|    ..|..::...|...|:    |.....:.|:....|  |   
Mouse   434 --------GIQTREVYCAQSLPATIASRTKEVSRPVERTLCLGPAPSASQLCNVPCSMD--C--- 485

  Fly   610 VTRQNNNKVLHIMSSVMGIHMHPWS-WSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTE--RLP 671
                       |:||        || |..|           ..::|       |.|.|.:  |:.
Mouse   486 -----------IVSS--------WSTWGPC-----------VFENC-------HDPQGKKGFRMR 513

  Fly   672 GEIYSLDAQCQLSFGNDFGYCPTDEE---CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHW 733
            .....:::.      ...|.||...|   |:...|:|       ..||..:..||...|| .||.
Mouse   514 QRHVLMEST------GPMGRCPHLAESVPCEDPMCHR-------WLASEGICIADHGKCG-LGHR 564

  Fly   734 CQRGKCVSNKHGYGRQVNGGWGP----------------------WTPFTPCSLTCGGGVQESRR 776
            ..:..|.:.:   |.:|:||..|                      ||.::.||.:|.....:.::
Mouse   565 ILKAVCQNER---GEEVSGGLCPVPPPPERMACEIPCRMDCVVSEWTVWSSCSQSCSNKNSDGKQ 626

  Fly   777 ECNQPV---PENGGKYCTGSR--KKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKW 836
            ..::.:   ...|||.|..|:  ::||.||.|.|   :....|...:.....|..:..:|....|
Mouse   627 TRSRSILALAGEGGKTCPSSQELQEYRLCNDHSC---TQLYWETSAWGSCSENTLVTALNVTIGW 688

  Fly   837 VPKYEKDAC-------KLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNS 894
               ..:..|       |:|| :...|...|.|       .|...:..:.|.....|...|..:.:
Mouse   689 ---NGEATCGVGIQTRKVFC-IKSHVGQVMTK-------RCPESTRPETVRPCFLPCKKDCLVTA 742

  Fly   895 IAKLDKC-GVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLY-------------YVTRIPKG 945
            .::...| ..|:..|.|..:....:::..  ..|.|.|...||:             |..:..|.
Mouse   743 FSEWTPCPRPCQPGNTTIKQSRYRIIIQE--AANGGQECPDTLFEERECEDISLCPSYRWKPQKW 805

  Fly   946 ASNIIITQ--------------RGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTG 996
            :|.|::.:              :|...:....::||..:..:      |..||        |..|
Mouse   806 SSCILVPESIRQGRTGTSEACGKGLQTRAVSCISDDNQSAEM------TECLK--------QMNG 856

  Fly   997 SSSVVEQVN-------TTYSWKLSRDLIVQIISLDVSP-SKRQDTVLLSYSYTIDKPPDYE--AE 1051
            ...:|::..       |...|.            ..:| ||..:...:.......|....|  .:
Mouse   857 MPPLVQECTIPCRDDCTFTPWS------------KFTPCSKNCEATQIRRRQLTGKSRKKEKCQD 909

  Fly  1052 VEIYRWEMQAPSNCD----------SLC------------------------EGRSHRLPACIST 1082
            ..:|......|..||          |.|                        ||...|..|| |.
Mouse   910 ASLYPLVEMEPCPCDTFMSHPYGNWSACILPEGKRDAQQGGLWVQGDDKECGEGVRFRAIAC-SN 973

  Fly  1083 TQGVKVAPQFCDKSAMPKIDDRA---CNTDCRLNLTVTSISECSAACGELGTR-------EKTYA 1137
            ..|..|.|.||:.|..  |.:..   |..||:|: ..:|...||::|| :|.|       ||.|:
Mouse   974 INGRPVDPSFCNSSGY--IQEACVIPCPFDCKLS-DWSSWGSCSSSCG-IGVRIRSKWLKEKPYS 1034

  Fly  1138 CVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTC-------SKSCGTGSQQREAH 1195
            ..:....:...|     ..::...|..:.||.:..||:..||.|       |..||.|:|.|...
Mouse  1035 GGRPCPKLDLKN-----QAQVHEAVPCYSECDQYSWVVEHWSPCKINNELRSPRCGRGTQSRRIR 1094

  Fly  1196 CYLHNSR----VSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCE 1256
            |.....|    |:..|||....|.        .|::|...  .|:...:|.|  |.|..|.:.|:
Mouse  1095 CVSTADREGGAVNRSLCNQDDAPQ--------ETQACSLL--CPSECVMSEW--GTWSRCPQSCD 1147

  Fly  1257 ------KTRSVSCSHPYGIGCGSRKPKDVRKC-----C-HIKYT-SDWTDC----SVQCGEGVKR 1304
                  :||.:.........||  :...||.|     | ..:|. ::|:.|    :|.||:||:.
Mouse  1148 PHAMQRRTRHLLRPSLNSRTCG--EDSQVRPCLLNENCFQFQYNLTEWSTCQLSENVSCGQGVRT 1210

  Fly  1305 KKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRT--TTKSCRINCK------------- 1354
            :..||.|        :..:.|.:|  :|..|.:.:|:..:  ....|.:||:             
Mouse  1211 RLLSCVR--------SDGKSVSMD--HCEQRNLEKPQRMSIPCLVECVVNCQLSGWTTWTECSQT 1265

  Fly  1355 -----------------------------------------WNASDWRRCP---ADCSEEYQTRD 1375
                                                     |...:|..|.   .||.|..|.|.
Mouse  1266 CGQGGRMSRTRFIIMPTQGEGRQCPTELTQQKPCPVTPCYSWVLGNWSACKLEGGDCGEGVQVRS 1330

  Fly  1376 VRCESFQGD------GVEDKHCDAKKRPSK----RRICN-----NCVRRQSRVISQCNCEGVEKR 1425
            ..|....|.      .||:..|.  :.|.:    :::|:     :|........|:|....::.|
Mouse  1331 FSCVVHNGSISHTAVPVEEALCG--EVPFQEGILKQLCSVPCPGDCHITPWSEWSKCELTCIDGR 1393

  Fly  1426 -----------RDFCFNSHKGRIACPTRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSR 1479
                       |.|...|.:.:.:||.:. :|...|| ...|.......|..::..|......|.
Mouse  1394 SFETTGRQSRSRTFIIQSFENQDSCPQQV-LETRPCT-GGKCYHYIWKASLWNNNERTVWCQRSD 1456

  Fly  1480 SLNSIGGSRNRGTP---RSCAD-LKEMHGYNKDG-------NYQLEVRSRMVHIYC 1524
            .||..||...:..|   |.|.. .|:...|...|       .|...:||.....||
Mouse  1457 GLNVTGGCSPQARPAAIRQCIPACKKPFSYCTQGGVCGCEKGYTEIMRSSGFLDYC 1512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep <295..394 CDD:460254 19/115 (17%)
ZnMc_ADAMTS_like 455..655 CDD:239801 35/216 (16%)
ADAMTS_CR_2 671..740 CDD:465496 15/71 (21%)
TSP1 754..806 CDD:214559 16/78 (21%)
ADAMTS_CR_3 815..911 CDD:437068 17/103 (17%)
TSP1 1172..1229 CDD:214559 19/67 (28%)
TSP1_ADAMTS 1243..1282 CDD:465950 11/44 (25%)
TSP1_ADAMTS 1355..1405 CDD:465950 15/67 (22%)
GON 1493..1687 CDD:462559 11/43 (26%)
Thsd7bXP_011246266.1 TSP1_ADAMTS 44..95 CDD:465950
TSP1_spondin 180..229 CDD:465948 12/70 (17%)
TSP1_spondin 337..398 CDD:465948 19/133 (14%)
TSP1_spondin 485..542 CDD:480609 18/102 (18%)
TSP1_spondin 602..660 CDD:465948 15/57 (26%)
TSP1_ADAMTS 665..733 CDD:465950 13/78 (17%)
TSP1_spondin 738..789 CDD:465948 9/52 (17%)
TSP1_ADAMTS 1065..1125 CDD:465950 20/67 (30%)
TSP1_spondin 1131..1177 CDD:480609 12/49 (24%)
TSP1_spondin 1251..1304 CDD:465948 1/52 (2%)
TSP1_spondin 1374..1433 CDD:480609 12/60 (20%)
Blue background indicates that the domain is not in the aligned region.

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