DRSC/TRiP Functional Genomics Resources

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Protein Alignment AdamTS-A and Thsd7b

DIOPT Version :9

Sequence 1:NP_996218.1 Gene:AdamTS-A / 41887 FlyBaseID:FBgn0286071 Length:1688 Species:Drosophila melanogaster
Sequence 2:XP_011246266.1 Gene:Thsd7b / 210417 MGIID:2443925 Length:1609 Species:Mus musculus


Alignment Length:1681 Identity:324/1681 - (19%)
Similarity:499/1681 - (29%) Gaps:628/1681 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 CHKYIQKMSTHWRQNACLYAC---CIAFLLGMLIMFHLGLRSAHKGQEELPQSTHP--------- 197
            |..:..:..|   :.|||..|   |:.                   .|..|.||.|         
Mouse   159 CEHFAPQPPT---EQACLIPCPRDCVV-------------------SEFSPWSTCPEGCGKKLQH 201

  Fly   198 ---LANSPPATPATLHPRRLDNDTSTDHEPPDGLDDLDEEEHSAFVMPTKVYNYS------LSEA 253
               :|.:||.......|...:   |...|.|... .|.:||:|   ...||..:|      |.|.
Mouse   202 RTRVAIAPPLYGGLQCPNLTE---SRACEAPVSC-PLGKEEYS---FSLKVGPWSKCRLPHLKEV 259

  Fly   254 DLIYESKRNSDINSFLKESASAFAMTGTYRNMSNEIWDPHPQYNLNVFGRQLHLVLRQDASFVHN 318
            ||   |.||  |..|..:|.....:|             |..|.                  .|:
Mouse   260 DL---SGRN--IQDFSSDSNEQVTLT-------------HQSYK------------------AHH 288

  Fly   319 HSMTHIRILKEGEEHPGPETEAEAEQRHLGCFYSGYVEDDPHSMVSVSLCGGMTGYIKTSFGALL 383
            ||            .|| :.....:.|.:.|..|    |..:::  :|||      ::.|| .|.
Mouse   289 HS------------QPG-DVVIGFQTRQVWCTRS----DGRNAL--LSLC------VRDSF-PLT 327

  Fly   384 IQ-----------------PVNRTSSDEVLHRVFRKSQRNARH-AVSKFELGLDDFMSKLEQVQE 430
            :|                 |.::|.....|....|...||.:| |:.    |..:....||:   
Mouse   328 VQPCVMPKDCETSEWSPWSPCSKTCRSGTLSPGVRSRSRNVKHIAIG----GGQECPELLEK--- 385

  Fly   431 EEQKSKSRKLNRKKRHYADVDNQVYTLEVLIAVDNSMKQFHGEDLQPYILILMSIVSSIFADASI 495
                                       |..||        .||.|||                  
Mouse   386 ---------------------------ETCIA--------EGEFLQP------------------ 397

  Fly   496 GNSIRILLVRLISLPNINDQTHSSNEMLKHFCQFINQSGYERDTAMLITRE--------PICGSV 552
                         .|..:.:|....|     ||          .::|:.:.        ||||. 
Mouse   398 -------------CPRYSWRTSEWKE-----CQ----------VSLLLEQHDPLWHETGPICGG- 433

  Fly   553 PGKICHMLGLAELGTVCSSS----SCSIVQDTGLPTAFTM----AHELGHILNMNHDDDDKCMPY 609
                    |:......|:.|    ..|..::...|...|:    |.....:.|:....|  |   
Mouse   434 --------GIQTREVYCAQSLPATIASRTKEVSRPVERTLCLGPAPSASQLCNVPCSMD--C--- 485

  Fly   610 VTRQNNNKVLHIMSSVMGIHMHPWS-WSKCSRHFVSEFLEKTDKSCLETSVGAHIPYGTE--RLP 671
                       |:||        || |..|           ..::|       |.|.|.:  |:.
Mouse   486 -----------IVSS--------WSTWGPC-----------VFENC-------HDPQGKKGFRMR 513

  Fly   672 GEIYSLDAQCQLSFGNDFGYCPTDEE---CKRLWCNRTSGNSNEQCASSNLPWADGTPCGSSGHW 733
            .....:::.      ...|.||...|   |:...|:|       ..||..:..||...|| .||.
Mouse   514 QRHVLMEST------GPMGRCPHLAESVPCEDPMCHR-------WLASEGICIADHGKCG-LGHR 564

  Fly   734 CQRGKCVSNKHGYGRQVNGGWGP----------------------WTPFTPCSLTCGGGVQESRR 776
            ..:..|.:.:   |.:|:||..|                      ||.::.||.:|.....:.::
Mouse   565 ILKAVCQNER---GEEVSGGLCPVPPPPERMACEIPCRMDCVVSEWTVWSSCSQSCSNKNSDGKQ 626

  Fly   777 ECNQPV---PENGGKYCTGSR--KKYRSCNTHQCPPGSMDPREQQCYAMNGRNMNIPGVNPDTKW 836
            ..::.:   ...|||.|..|:  ::||.||.|.|   :....|...:.....|..:..:|....|
Mouse   627 TRSRSILALAGEGGKTCPSSQELQEYRLCNDHSC---TQLYWETSAWGSCSENTLVTALNVTIGW 688

  Fly   837 VPKYEKDAC-------KLFCRMDMKVTYFMLKSMVTDGTSCAVDSFDKCVNGICRPAGCDNELNS 894
               ..:..|       |:|| :...|...|.|       .|...:..:.|.....|...|..:.:
Mouse   689 ---NGEATCGVGIQTRKVFC-IKSHVGQVMTK-------RCPESTRPETVRPCFLPCKKDCLVTA 742

  Fly   895 IAKLDKC-GVCEGRNDTCHEVTGNLLVSNLLGLNDGNEPNKTLY-------------YVTRIPKG 945
            .::...| ..|:..|.|..:....:::..  ..|.|.|...||:             |..:..|.
Mouse   743 FSEWTPCPRPCQPGNTTIKQSRYRIIIQE--AANGGQECPDTLFEERECEDISLCPSYRWKPQKW 805

  Fly   946 ASNIIITQ--------------RGYPDQNFIVLTDDRDNELLNGKFLKTYPLKFVYAGVTMQYTG 996
            :|.|::.:              :|...:....::||..:..:      |..||        |..|
Mouse   806 SSCILVPESIRQGRTGTSEACGKGLQTRAVSCISDDNQSAEM------TECLK--------QMNG 856

  Fly   997 SSSVVEQVN-------TTYSWKLSRDLIVQIISLDVSP-SKRQDTVLLSYSYTIDKPPDYE--AE 1051
            ...:|::..       |...|.            ..:| ||..:...:.......|....|  .:
Mouse   857 MPPLVQECTIPCRDDCTFTPWS------------KFTPCSKNCEATQIRRRQLTGKSRKKEKCQD 909

  Fly  1052 VEIYRWEMQAPSNCD----------SLC------------------------EGRSHRLPACIST 1082
            ..:|......|..||          |.|                        ||...|..|| |.
Mouse   910 ASLYPLVEMEPCPCDTFMSHPYGNWSACILPEGKRDAQQGGLWVQGDDKECGEGVRFRAIAC-SN 973

  Fly  1083 TQGVKVAPQFCDKSAMPKIDDRA---CNTDCRLNLTVTSISECSAACGELGTR-------EKTYA 1137
            ..|..|.|.||:.|..  |.:..   |..||:|: ..:|...||::|| :|.|       ||.|:
Mouse   974 INGRPVDPSFCNSSGY--IQEACVIPCPFDCKLS-DWSSWGSCSSSCG-IGVRIRSKWLKEKPYS 1034

  Fly  1138 CVQTFTNMQRSNIVDMSYCKLKFDVAYHEECREGCWVLSEWSTC-------SKSCGTGSQQREAH 1195
            ..:....:...|     ..::...|..:.||.:..||:..||.|       |..||.|:|.|...
Mouse  1035 GGRPCPKLDLKN-----QAQVHEAVPCYSECDQYSWVVEHWSPCKINNELRSPRCGRGTQSRRIR 1094

  Fly  1196 CYLHNSR----VSDDLCNPRTKPHLNTLIGICNTESCPTYTKSPNALAVSNWVIGEWGECNEWCE 1256
            |.....|    |:..|||....|.        .|::|...  .|:...:|.|  |.|..|.:.|:
Mouse  1095 CVSTADREGGAVNRSLCNQDDAPQ--------ETQACSLL--CPSECVMSEW--GTWSRCPQSCD 1147

  Fly  1257 ------KTRSVSCSHPYGIGCGSRKPKDVRKC-----C-HIKYT-SDWTDC----SVQCGEGVKR 1304
                  :||.:.........||  :...||.|     | ..:|. ::|:.|    :|.||:||:.
Mouse  1148 PHAMQRRTRHLLRPSLNSRTCG--EDSQVRPCLLNENCFQFQYNLTEWSTCQLSENVSCGQGVRT 1210

  Fly  1305 KKQSCTRVYKPDVPGTRKRRVYVDESYCISRKVHRPKLRT--TTKSCRINCK------------- 1354
            :..||.|        :..:.|.:|  :|..|.:.:|:..:  ....|.:||:             
Mouse  1211 RLLSCVR--------SDGKSVSMD--HCEQRNLEKPQRMSIPCLVECVVNCQLSGWTTWTECSQT 1265

  Fly  1355 -----------------------------------------WNASDWRRCP---ADCSEEYQTRD 1375
                                                     |...:|..|.   .||.|..|.|.
Mouse  1266 CGQGGRMSRTRFIIMPTQGEGRQCPTELTQQKPCPVTPCYSWVLGNWSACKLEGGDCGEGVQVRS 1330

  Fly  1376 VRCESFQGD------GVEDKHCDAKKRPSK----RRICN-----NCVRRQSRVISQCNCEGVEKR 1425
            ..|....|.      .||:..|.  :.|.:    :::|:     :|........|:|....::.|
Mouse  1331 FSCVVHNGSISHTAVPVEEALCG--EVPFQEGILKQLCSVPCPGDCHITPWSEWSKCELTCIDGR 1393

  Fly  1426 -----------RDFCFNSHKGRIACPTRARVERHSCTPPPHCRRRSAIGSSISSRPRGTGVSSSR 1479
                       |.|...|.:.:.:||.:. :|...|| ...|.......|..::..|......|.
Mouse  1394 SFETTGRQSRSRTFIIQSFENQDSCPQQV-LETRPCT-GGKCYHYIWKASLWNNNERTVWCQRSD 1456

  Fly  1480 SLNSIGGSRNRGTP---RSCAD-LKEMHGYNKDG-------NYQLEVRSRMVHIYC 1524
            .||..||...:..|   |.|.. .|:...|...|       .|...:||.....||
Mouse  1457 GLNVTGGCSPQARPAAIRQCIPACKKPFSYCTQGGVCGCEKGYTEIMRSSGFLDYC 1512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdamTS-ANP_996218.1 Pep_M12B_propep 286..394 CDD:279848 20/124 (16%)
ZnMc_ADAMTS_like 455..655 CDD:239801 35/216 (16%)
Reprolysin 457..655 CDD:279729 35/214 (16%)
Salp15 <696..745 CDD:288931 13/51 (25%)
TSP1 754..806 CDD:214559 16/78 (21%)
ADAM_spacer1 937..1042 CDD:283607 18/139 (13%)
TSP1 1172..1229 CDD:214559 19/67 (28%)
GON 1495..1687 CDD:285848 9/38 (24%)
Thsd7bXP_011246266.1 TSP1_ADAMTS 44..95 CDD:408800
TSP1_ADAMTS <137..176 CDD:408800 5/19 (26%)
TSP1_spondin 180..229 CDD:408798 12/70 (17%)
TSP1_spondin 337..398 CDD:408798 19/133 (14%)
TSP1_spondin 602..660 CDD:408798 15/57 (26%)
TSP1_ADAMTS 665..734 CDD:408800 13/79 (16%)
TSP1_spondin 738..789 CDD:408798 9/52 (17%)
TSP1_ADAMTS 1065..1125 CDD:408800 20/67 (30%)
TSP1_spondin 1131..1177 CDD:408798 12/49 (24%)
TSP1_spondin 1251..1304 CDD:408798 1/52 (2%)
TSP1_spondin 1374..1433 CDD:408798 12/60 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3538
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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